PVLA vs. TLSA

Last updated Jun 4, 2026

PVLA (Palvella Therapeutics, Inc) and TLSA (Tiziana Life Sciences PLC) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past year, PVLA returned 372.26% vs -16.90% for TLSA. At a 0.18 correlation, their price movements are largely independent.

Performance

PVLA vs. TLSA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Palvella Therapeutics, Inc (PVLA) and Tiziana Life Sciences PLC (TLSA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, PVLA achieves a 10.27% return, which is significantly higher than TLSA's -20.81% return.

PVLA

• 1D: 10.27%
• 1M: -9.55%
• YTD: 10.27%
• 6M: 25.58%
• 1Y: 372.26%
• 3Y*: —
• 5Y*: —
• 10Y*: —

TLSA

• 1D: -13.24%
• 1M: -15.11%
• YTD: -20.81%
• 6M: -30.18%
• 1Y: -16.90%
• 3Y*: 4.64%
• 5Y*: -12.87%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

PVLA vs. TLSA - Yearly Performance Comparison

	2026 (YTD)	2025	2024
PVLA Palvella Therapeutics, Inc	10.27%	772.25%	-6.47%
TLSA Tiziana Life Sciences PLC	-20.81%	114.02%	-25.09%

Correlation

The correlation between PVLA and TLSA is 0.12, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.12
Correlation (All Time) Calculated using the full available price history since Dec 17, 2024	0.18

Fundamentals

Market Cap PVLA : $1.30B TLSA : $70.17M
EPS PVLA : -$3.75 TLSA : -$0.59
PB Ratio PVLA : 46.41 TLSA : 1.35K
Total Revenue (TTM) PVLA : $0.00 TLSA : $0.00
Gross Profit (TTM) PVLA : $0.00 TLSA : -$421.00K
EBITDA (TTM) PVLA : -$14.75M TLSA : -$42.26M

Return for Risk

PVLA vs. TLSA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PVLA

PVLA Risk / Return Rank: 96
PVLA Sharpe Ratio Rank: 98
PVLA Sortino Ratio Rank: 95
PVLA Omega Ratio Rank: 92
PVLA Calmar Ratio Rank: 98
PVLA Martin Ratio Rank: 97

TLSA

TLSA Risk / Return Rank: 33
TLSA Sharpe Ratio Rank: 32
TLSA Sortino Ratio Rank: 36
TLSA Omega Ratio Rank: 35
TLSA Calmar Ratio Rank: 31
TLSA Martin Ratio Rank: 32

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PVLA vs. TLSA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Palvella Therapeutics, Inc (PVLA) and Tiziana Life Sciences PLC (TLSA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PVLA	TLSA	Difference
Sharpe ratio Return per unit of total volatility	4.57	-0.21	+4.79
Sortino ratio Return per unit of downside risk	4.12	0.25	+3.88
Omega ratio Gain probability vs. loss probability	1.49	1.03	+0.46
Calmar ratio Return relative to maximum drawdown	12.54	-0.31	+12.85
Martin ratio Return relative to average drawdown	28.59	-0.50	+29.08
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PVLA vs. TLSA - Sharpe Ratio Comparison

The current PVLA Sharpe Ratio is 4.57, which is higher than the TLSA Sharpe Ratio of -0.21. The chart below compares the historical Sharpe Ratios of PVLA and TLSA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	PVLA	TLSA	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	4.57	-0.21	+4.79
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	-0.14	—
Sharpe Ratio (All Time) Calculated using the full available price history	4.30	-0.04	+4.34

Drawdowns

PVLA vs. TLSA - Drawdown Comparison

The maximum PVLA drawdown since its inception was -31.48%, smaller than the maximum TLSA drawdown of -94.03%. Use the drawdown chart below to compare losses from any high point for PVLA and TLSA.

Drawdown Indicators

	PVLA	TLSA	Difference
Max Drawdown Largest peak-to-trough decline	-31.48%	-94.03%	+62.55%
Max Drawdown (1Y) Largest decline over 1 year	-29.93%	-54.00%	+24.07%
Max Drawdown (3Y) Largest decline over 3 years	—	-55.66%	—
Max Drawdown (5Y) Largest decline over 5 years	—	-84.02%	—
Current Drawdown Current decline from peak	-22.19%	-83.12%	+60.93%
Average Drawdown Average peak-to-trough decline	-10.66%	-70.29%	+59.63%
Ulcer Index Depth and duration of drawdowns from previous peaks	13.10%	34.09%	-20.99%

Volatility

PVLA vs. TLSA - Volatility Comparison

The current volatility for Palvella Therapeutics, Inc (PVLA) is 24.98%, while Tiziana Life Sciences PLC (TLSA) has a volatility of 26.73%. This indicates that PVLA experiences smaller price fluctuations and is considered to be less risky than TLSA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PVLA	TLSA	Difference
Volatility (1M) Calculated over the trailing 1-month period	24.98%	26.73%	-1.75%
Volatility (6M) Calculated over the trailing 6-month period	62.87%	54.90%	+7.97%
Volatility (1Y) Calculated over the trailing 1-year period	82.14%	79.45%	+2.69%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	82.90%	92.71%	-9.81%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	82.90%	112.60%	-29.70%

Dividends

PVLA vs. TLSA - Dividend Comparison

Neither PVLA nor TLSA has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both PVLA and TLSA in my portfolio?

PVLA and TLSA have a correlation of 0.12, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, PVLA or TLSA?

TLSA has higher volatility (26.73%) compared to PVLA (24.98%). In terms of maximum drawdown, PVLA dropped -31.48% vs TLSA's -94.03%.

Which has better risk-adjusted returns?

PVLA currently has the higher Sharpe Ratio (4.57 vs -0.21), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.