PVLA vs. TLSA
PVLA (Palvella Therapeutics, Inc) and TLSA (Tiziana Life Sciences PLC) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past year, PVLA returned 426.53% vs -25.16% for TLSA. At a 0.18 correlation, their price movements are largely independent.
Performance
PVLA vs. TLSA - Performance Comparison
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Returns By Period
In the year-to-date period, PVLA achieves a 13.38% return, which is significantly higher than TLSA's -22.15% return.
PVLA
- 1D
- -0.13%
- 1M
- 4.11%
- YTD
- 13.38%
- 6M
- 18.36%
- 1Y
- 426.53%
- 3Y*
- —
- 5Y*
- —
- 10Y*
- —
TLSA
- 1D
- 0.87%
- 1M
- -21.62%
- YTD
- -22.15%
- 6M
- -20.55%
- 1Y
- -25.16%
- 3Y*
- 17.23%
- 5Y*
- -14.03%
- 10Y*
- —
PVLA vs. TLSA - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | |
|---|---|---|---|
PVLA Palvella Therapeutics, Inc | 13.38% | 772.25% | -8.27% |
TLSA Tiziana Life Sciences PLC | -22.15% | 114.02% | -26.02% |
Correlation
The correlation between PVLA and TLSA is 0.16, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.16 |
Correlation (All Time) Calculated using the full available price history since Dec 16, 2024 | 0.18 |
Fundamentals
PVLA:
$1.34B
TLSA:
$68.98M
PVLA:
-$3.75
TLSA:
-$0.59
PVLA:
47.72
TLSA:
1.33K
PVLA:
$0.00
TLSA:
$0.00
PVLA:
$0.00
TLSA:
-$421.00K
PVLA:
-$14.75M
TLSA:
-$42.26M
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Return for Risk
PVLA vs. TLSA — Risk / Return Rank
PVLA
TLSA
PVLA vs. TLSA - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Palvella Therapeutics, Inc (PVLA) and Tiziana Life Sciences PLC (TLSA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| PVLA | TLSA | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +5.64 | ||
| Sortino ratioReturn per unit of downside risk | +4.44 | ||
| Omega ratioGain probability vs. loss probability | 1.54 | 1.00 | +0.53 |
| Calmar ratioReturn relative to maximum drawdown | 13.82 | -0.44 | +14.27 |
| Martin ratioReturn relative to average drawdown | 31.14 | -0.70 | +31.84 |
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Drawdowns
PVLA vs. TLSA - Drawdown Comparison
The maximum PVLA drawdown since its inception was -31.48%, smaller than the maximum TLSA drawdown of -94.03%. Use the drawdown chart below to compare losses from any high point for PVLA and TLSA.
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Drawdown Indicators
| PVLA | TLSA | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -31.48% | -94.03% | +62.55% |
Max Drawdown (1Y)Largest decline over 1 year | -31.11% | -56.80% | +25.69% |
Max Drawdown (3Y)Largest decline over 3 years | — | -56.80% | — |
Max Drawdown (5Y)Largest decline over 5 years | — | -83.32% | — |
Current DrawdownCurrent decline from peak | -19.99% | -83.40% | +63.41% |
Average DrawdownAverage peak-to-trough decline | -11.16% | -70.35% | +59.19% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 13.79% | 36.19% | -22.40% |
Volatility
PVLA vs. TLSA - Volatility Comparison
Palvella Therapeutics, Inc (PVLA) and Tiziana Life Sciences PLC (TLSA) have volatilities of 19.68% and 19.72%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| PVLA | TLSA | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 19.68% | 19.72% | -0.04% |
Volatility (6M)Calculated over the trailing 6-month period | 61.91% | 53.62% | +8.29% |
Volatility (1Y)Calculated over the trailing 1-year period | 80.85% | 79.22% | +1.63% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 82.11% | 92.68% | -10.57% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 82.11% | 112.54% | -30.43% |
Dividends
PVLA vs. TLSA - Dividend Comparison
Neither PVLA nor TLSA has paid dividends to shareholders.
Financials
PVLA vs. TLSA - Financials Comparison
This section allows you to compare key financial metrics between Palvella Therapeutics, Inc and Tiziana Life Sciences PLC. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
Frequently Asked Questions
PVLA and TLSA have a correlation of 0.16, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
TLSA has higher volatility (19.72%) compared to PVLA (19.68%). In terms of maximum drawdown, PVLA dropped -31.48% vs TLSA's -94.03%.
PVLA currently has the higher Sharpe Ratio (5.32 vs -0.32), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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