TLSA vs. TQQQ

Last updated Apr 1, 2026

Compare and contrast key facts about Tiziana Life Sciences PLC (TLSA) and ProShares UltraPro QQQ (TQQQ).

TQQQ is a passively managed fund by ProShares that tracks the performance of the NASDAQ-100 Index (300%). It was launched on Feb 9, 2010.

Performance

TLSA vs. TQQQ - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Tiziana Life Sciences PLC (TLSA) and ProShares UltraPro QQQ (TQQQ). The values are adjusted to include any dividend payments, if applicable.

TLSA vs. TQQQ - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
TLSA Tiziana Life Sciences PLC	-21.48%	114.02%	24.32%	-6.43%	-37.66%	-52.48%	86.96%	-27.52%	-10.78%
TQQQ ProShares UltraPro QQQ	-20.81%	34.35%	58.27%	198.04%	-79.09%	82.98%	110.05%	133.84%	-12.52%

Returns By Period

The year-to-date returns for both investments are quite close, with TLSA having a -21.48% return and TQQQ slightly higher at -20.81%.

TLSA

• 1D: -5.65%
• 1M: -19.31%
• YTD: -21.48%
• 6M: -45.83%
• 1Y: 8.33%
• 3Y*: 2.34%
• 5Y*: -15.71%
• 10Y*: —

TQQQ

• 1D: 10.00%
• 1M: -15.69%
• YTD: -20.81%
• 6M: -19.12%
• 1Y: 46.49%
• 3Y*: 45.09%
• 5Y*: 12.72%
• 10Y*: 34.82%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

TLSA vs. TQQQ — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

TLSA

TLSA Risk / Return Rank: 46
TLSA Sharpe Ratio Rank: 45
TLSA Sortino Ratio Rank: 52
TLSA Omega Ratio Rank: 48
TLSA Calmar Ratio Rank: 43
TLSA Martin Ratio Rank: 43

TQQQ

TQQQ Risk / Return Rank: 50
TQQQ Sharpe Ratio Rank: 40
TQQQ Sortino Ratio Rank: 57
TQQQ Omega Ratio Rank: 56
TQQQ Calmar Ratio Rank: 55
TQQQ Martin Ratio Rank: 44

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

TLSA vs. TQQQ - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Tiziana Life Sciences PLC (TLSA) and ProShares UltraPro QQQ (TQQQ). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	TLSA	TQQQ	Difference
Sharpe ratio Return per unit of total volatility	0.09	0.69	-0.60
Sortino ratio Return per unit of downside risk	0.87	1.37	-0.50
Omega ratio Gain probability vs. loss probability	1.09	1.19	-0.10
Calmar ratio Return relative to maximum drawdown	0.08	1.25	-1.17
Martin ratio Return relative to average drawdown	0.16	3.87	-3.71
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

TLSA vs. TQQQ - Sharpe Ratio Comparison

The current TLSA Sharpe Ratio is 0.09, which is lower than the TQQQ Sharpe Ratio of 0.69. The chart below compares the historical Sharpe Ratios of TLSA and TQQQ, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	TLSA	TQQQ	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.09	0.69	-0.60
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.17	0.19	-0.36
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.53	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.04	0.64	-0.68

Correlation

The correlation between TLSA and TQQQ is 0.14, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

TLSA vs. TQQQ - Dividend Comparison

TLSA has not paid dividends to shareholders, while TQQQ's dividend yield for the trailing twelve months is around 0.76%.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
TLSA Tiziana Life Sciences PLC	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
TQQQ ProShares UltraPro QQQ	0.76%	0.65%	1.27%	1.26%	0.57%	0.00%	0.00%	0.06%	0.11%	0.00%	0.00%	0.01%

Drawdowns

TLSA vs. TQQQ - Drawdown Comparison

The maximum TLSA drawdown since its inception was -94.03%, which is greater than TQQQ's maximum drawdown of -81.66%. Use the drawdown chart below to compare losses from any high point for TLSA and TQQQ.

Drawdown Indicators

	TLSA	TQQQ	Difference
Max Drawdown Largest peak-to-trough decline	-94.03%	-81.66%	-12.37%
Max Drawdown (1Y) Largest decline over 1 year	-53.20%	-36.97%	-16.23%
Max Drawdown (5Y) Largest decline over 5 years	-86.76%	-81.66%	-5.10%
Max Drawdown (10Y) Largest decline over 10 years	—	-81.66%	—
Current Drawdown Current decline from peak	-83.26%	-30.66%	-52.60%
Average Drawdown Average peak-to-trough decline	-70.04%	-18.66%	-51.38%
Ulcer Index Depth and duration of drawdowns from previous peaks	28.80%	12.00%	+16.80%

Volatility

TLSA vs. TQQQ - Volatility Comparison

Tiziana Life Sciences PLC (TLSA) and ProShares UltraPro QQQ (TQQQ) have volatilities of 20.16% and 19.43%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	TLSA	TQQQ	Difference
Volatility (1M) Calculated over the trailing 1-month period	20.16%	19.43%	+0.73%
Volatility (6M) Calculated over the trailing 6-month period	51.29%	38.32%	+12.97%
Volatility (1Y) Calculated over the trailing 1-year period	89.30%	67.26%	+22.04%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	92.73%	66.55%	+26.18%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	113.28%	65.83%	+47.45%