TLSA vs. TSLL
TLSA (Tiziana Life Sciences PLC) is a stock, while TSLL (Direxion Daily TSLA Bull 2X ETF) is Leveraged Equities fund actively managed by Direxion. Over the past 3 years, TLSA returned 22.11%/yr vs -9.52%/yr for TSLL. At a 0.08 correlation, their price movements are largely independent.
Performance
TLSA vs. TSLL - Performance Comparison
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Returns By Period
In the year-to-date period, TLSA achieves a -16.78% return, which is significantly higher than TSLL's -34.36% return.
TLSA
- 1D
- -6.77%
- 1M
- 12.73%
- 6M
- -8.15%
- YTD
- -16.78%
- 1Y
- -16.22%
- 3Y*
- 22.11%
- 5Y*
- -8.94%
- 10Y*
- —
TSLL
- 1D
- 0.65%
- 1M
- -8.41%
- 6M
- -33.07%
- YTD
- -34.36%
- 1Y
- 13.14%
- 3Y*
- -9.52%
- 5Y*
- —
- 10Y*
- —
TLSA vs. TSLL - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | |
|---|---|---|---|---|---|
TLSA Tiziana Life Sciences PLC | -16.78% | 114.02% | 24.32% | -6.43% | -18.01% |
TSLL Direxion Daily TSLA Bull 2X ETF | -34.36% | -26.80% | 99.63% | 139.86% | -74.99% |
Correlation
The correlation between TLSA and TSLL is 0.13, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.13 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.05 |
Correlation (All Time) Calculated using the full available price history since Aug 9, 2022 | 0.08 |
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Return for Risk
TLSA vs. TSLL — Risk / Return Rank
TLSA
TSLL
TLSA vs. TSLL - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Tiziana Life Sciences PLC (TLSA) and Direxion Daily TSLA Bull 2X ETF (TSLL). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| TLSA | TSLL | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -0.35 | ||
| Sortino ratioReturn per unit of downside risk | -0.58 | ||
| Omega ratioGain probability vs. loss probability | 1.03 | 1.10 | -0.07 |
| Calmar ratioReturn relative to maximum drawdown | -0.29 | 0.24 | -0.53 |
| Martin ratioReturn relative to average drawdown | -0.43 | 0.46 | -0.89 |
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Drawdowns
TLSA vs. TSLL - Drawdown Comparison
The maximum TLSA drawdown since its inception was -94.03%, which is greater than TSLL's maximum drawdown of -82.88%. Use the drawdown chart below to compare losses from any high point for TLSA and TSLL.
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Drawdown Indicators
| TLSA | TSLL | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -94.03% | -82.88% | -11.15% |
Max Drawdown (1Y)Largest decline over 1 year | -56.80% | -54.75% | -2.05% |
Max Drawdown (3Y)Largest decline over 3 years | -56.80% | -82.88% | +26.08% |
Max Drawdown (5Y)Largest decline over 5 years | -80.42% | — | — |
Current DrawdownCurrent decline from peak | -82.26% | -66.86% | -15.40% |
Average DrawdownAverage peak-to-trough decline | -70.44% | -54.09% | -16.35% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 37.95% | 28.65% | +9.30% |
Volatility
TLSA vs. TSLL - Volatility Comparison
The current volatility for Tiziana Life Sciences PLC (TLSA) is 22.48%, while Direxion Daily TSLA Bull 2X ETF (TSLL) has a volatility of 33.88%. This indicates that TLSA experiences smaller price fluctuations and is considered to be less risky than TSLL based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| TLSA | TSLL | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 22.48% | 33.88% | -11.40% |
Volatility (6M)Calculated over the trailing 6-month period | 55.48% | 62.30% | -6.82% |
Volatility (1Y)Calculated over the trailing 1-year period | 80.17% | 89.21% | -9.04% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 93.00% | 107.21% | -14.21% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 112.37% | 107.21% | +5.16% |
Dividends
TLSA vs. TSLL - Dividend Comparison
TLSA has not paid dividends to shareholders, while TSLL's dividend yield for the trailing twelve months is around 7.98%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
TLSA Tiziana Life Sciences PLC | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
TSLL Direxion Daily TSLA Bull 2X ETF | 7.98% | 5.00% | 2.47% | 4.44% | 1.57% |
Frequently Asked Questions
TLSA and TSLL have a correlation of 0.13, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
TSLL has higher volatility (33.88%) compared to TLSA (22.48%). In terms of maximum drawdown, TLSA dropped -94.03% vs TSLL's -82.88%.
TSLL currently has the higher Sharpe Ratio (0.15 vs -0.20), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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