TLSA vs. TSLL
TLSA (Tiziana Life Sciences PLC) is a stock, while TSLL (Direxion Daily TSLA Bull 2X ETF) is Leveraged Equities fund actively managed by Direxion. Over the past 3 years, TLSA returned 4.64%/yr vs 9.79%/yr for TSLL. At a 0.09 correlation, their price movements are largely independent.
Performance
TLSA vs. TSLL - Performance Comparison
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Returns By Period
The year-to-date returns for both stocks are quite close, with TLSA having a -20.81% return and TSLL slightly lower at -20.85%.
TLSA
- 1D
- -13.24%
- 1M
- -15.11%
- YTD
- -20.81%
- 6M
- -30.18%
- 1Y
- -16.90%
- 3Y*
- 4.64%
- 5Y*
- -12.87%
- 10Y*
- —
TSLL
- 1D
- 0.00%
- 1M
- 13.88%
- YTD
- -20.85%
- 6M
- -21.38%
- 1Y
- 7.17%
- 3Y*
- 9.79%
- 5Y*
- —
- 10Y*
- —
TLSA vs. TSLL - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | |
|---|---|---|---|---|---|
TLSA Tiziana Life Sciences PLC | -20.81% | 114.02% | 24.32% | -6.43% | -18.00% |
TSLL Direxion Daily TSLA Bull 2X ETF | -20.85% | -26.80% | 99.63% | 139.86% | -73.85% |
Correlation
The correlation between TLSA and TSLL is 0.14, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.14 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.06 |
Correlation (All Time) Calculated using the full available price history since Aug 10, 2022 | 0.09 |
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Return for Risk
TLSA vs. TSLL — Risk / Return Rank
TLSA
TSLL
TLSA vs. TSLL - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Tiziana Life Sciences PLC (TLSA) and Direxion Daily TSLA Bull 2X ETF (TSLL). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| TLSA | TSLL | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -0.29 | ||
| Sortino ratioReturn per unit of downside risk | -0.53 | ||
| Omega ratioGain probability vs. loss probability | 1.03 | 1.09 | -0.07 |
| Calmar ratioReturn relative to maximum drawdown | -0.31 | 0.13 | -0.45 |
| Martin ratioReturn relative to average drawdown | -0.50 | 0.27 | -0.77 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| TLSA | TSLL | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | -0.21 | 0.08 | -0.29 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | -0.14 | — | — |
Sharpe Ratio (All Time)Calculated using the full available price history | -0.04 | -0.08 | +0.04 |
Drawdowns
TLSA vs. TSLL - Drawdown Comparison
The maximum TLSA drawdown since its inception was -94.03%, which is greater than TSLL's maximum drawdown of -82.88%. Use the drawdown chart below to compare losses from any high point for TLSA and TSLL.
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Drawdown Indicators
| TLSA | TSLL | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -94.03% | -82.88% | -11.15% |
Max Drawdown (1Y)Largest decline over 1 year | -54.00% | -54.75% | +0.75% |
Max Drawdown (3Y)Largest decline over 3 years | -55.66% | -82.88% | +27.22% |
Max Drawdown (5Y)Largest decline over 5 years | -84.02% | — | — |
Current DrawdownCurrent decline from peak | -83.12% | -60.03% | -23.09% |
Average DrawdownAverage peak-to-trough decline | -70.29% | -53.82% | -16.47% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 34.09% | 26.72% | +7.37% |
Volatility
TLSA vs. TSLL - Volatility Comparison
Tiziana Life Sciences PLC (TLSA) has a higher volatility of 26.73% compared to Direxion Daily TSLA Bull 2X ETF (TSLL) at 24.26%. This indicates that TLSA's price experiences larger fluctuations and is considered to be riskier than TSLL based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| TLSA | TSLL | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 26.73% | 24.26% | +2.47% |
Volatility (6M)Calculated over the trailing 6-month period | 54.90% | 54.47% | +0.43% |
Volatility (1Y)Calculated over the trailing 1-year period | 79.45% | 92.38% | -12.93% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 92.71% | 106.87% | -14.16% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 112.60% | 106.87% | +5.73% |
Dividends
TLSA vs. TSLL - Dividend Comparison
TLSA has not paid dividends to shareholders, while TSLL's dividend yield for the trailing twelve months is around 6.46%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
TLSA Tiziana Life Sciences PLC | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
TSLL Direxion Daily TSLA Bull 2X ETF | 6.46% | 5.00% | 2.47% | 4.44% | 1.57% |
Frequently Asked Questions
TLSA and TSLL have a correlation of 0.14, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
TLSA has higher volatility (26.73%) compared to TSLL (24.26%). In terms of maximum drawdown, TLSA dropped -94.03% vs TSLL's -82.88%.
TSLL currently has the higher Sharpe Ratio (0.08 vs -0.21), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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