TLSA vs. TSLL
TLSA (Tiziana Life Sciences PLC) is a stock, while TSLL (Direxion Daily TSLA Bull 2X ETF) is Leveraged Equities fund actively managed by Direxion. Over the past 3 years, TLSA returned 13.67%/yr vs -17.93%/yr for TSLL. Their 0.08 correlation means their historical movements had little consistent relationship.
Performance
TLSA vs. TSLL - Performance Comparison
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Returns By Period
In the year-to-date period, TLSA achieves a -34.95% return, which is significantly higher than TSLL's -58.49% return.
TLSA
- 1D
- -5.89%
- 1M
- -26.01%
- 6M
- -32.69%
- YTD
- -34.95%
- 1Y
- -59.27%
- 3Y*
- 13.67%
- 5Y*
- -14.16%
- 10Y*
- —
- ALL TIME*
- -9.56%
TSLL
- 1D
- 6.84%
- 1M
- -36.50%
- 6M
- -51.69%
- YTD
- -58.49%
- 1Y
- -20.06%
- 3Y*
- -17.93%
- 5Y*
- —
- 10Y*
- —
- ALL TIME*
- -22.42%
Liquidity Comparison
| Position | Avg. Volume Value (2W) | Avg. Volume Value (1M) | Avg. Volume Value (3M) |
|---|---|---|---|
| $528.10K | $420.99K | $346.44K | |
| $747.52M | $658.50M | $943.03M |
TLSA vs. TSLL - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | |
|---|---|---|---|---|---|
TLSA Tiziana Life Sciences PLC | -34.95% | 114.02% | 24.32% | -6.43% | -18.01% |
TSLL Direxion Daily TSLA Bull 2X ETF | -58.49% | -26.80% | 99.63% | 139.86% | -74.99% |
Correlation
The correlation between TLSA and TSLL is 0.11, which is low. Their historical price movements had little consistent relationship.
| Correlation | |
|---|---|
Correlation (1Y) Focuses on recent behavior, but can change the most. | 0.11 |
Correlation (3Y) Balances recent behavior with more history. | 0.06 |
Correlation (All Time) Calculated using the full available price history since Aug 9, 2022 | 0.08 |
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Return for Risk
TLSA vs. TSLL — Risk / Return Rank
TLSA
TSLL
TLSA vs. TSLL - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Tiziana Life Sciences PLC (TLSA) and Direxion Daily TSLA Bull 2X ETF (TSLL). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| TLSA | TSLL | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -0.53 | ||
| Sortino ratioReturn per unit of downside risk | -1.41 | ||
| Omega ratioGain probability vs. loss probability | 0.89 | 1.04 | -0.15 |
| Calmar ratioReturn relative to maximum drawdown | -0.93 | -0.29 | -0.65 |
| Martin ratioReturn relative to average drawdown | -1.50 | -0.63 | -0.87 |
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Drawdowns
TLSA vs. TSLL - Drawdown Comparison
The maximum TLSA drawdown since its inception was -94.03%, which is greater than TSLL's maximum drawdown of -82.88%. Use the drawdown chart below to compare losses from any high point for TLSA and TSLL.
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Drawdown Indicators
| TLSA | TSLL | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -94.03% | -82.88% | -11.15% |
Max Drawdown (1Y)Largest decline over 1 year | -63.72% | -70.13% | +6.41% |
Max Drawdown (3Y)Largest decline over 3 years | -64.30% | -82.88% | +18.58% |
Max Drawdown (5Y)Largest decline over 5 years | -79.95% | — | — |
Current DrawdownCurrent decline from peak | -86.13% | -79.04% | -7.09% |
Average DrawdownAverage peak-to-trough decline | -70.55% | -54.39% | -16.16% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 39.63% | 31.89% | +7.74% |
Volatility
TLSA vs. TSLL - Volatility Comparison
The current volatility for Tiziana Life Sciences PLC (TLSA) is 29.02%, while Direxion Daily TSLA Bull 2X ETF (TSLL) has a volatility of 41.90%. This indicates that TLSA experiences smaller price fluctuations and is considered to be less risky than TSLL based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| TLSA | TSLL | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 29.02% | 41.90% | -12.88% |
Volatility (6M)Calculated over the trailing 6-month period | 55.78% | 70.55% | -14.77% |
Volatility (1Y)Calculated over the trailing 1-year period | 79.10% | 92.52% | -13.42% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 93.16% | 107.77% | -14.61% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 112.27% | 107.77% | +4.50% |
Dividends
TLSA vs. TSLL - Dividend Comparison
TLSA has not paid dividends to shareholders, while TSLL's dividend yield for the trailing twelve months is around 12.62%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
TLSA Tiziana Life Sciences PLC | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
TSLL Direxion Daily TSLA Bull 2X ETF | 12.62% | 5.00% | 2.47% | 4.44% | 1.57% |
Frequently Asked Questions
TLSA and TSLL have a correlation of 0.11, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
TSLL has higher volatility (41.90%) compared to TLSA (29.02%). In terms of maximum drawdown, TLSA dropped -94.03% vs TSLL's -82.88%.
TSLL currently has the higher Sharpe Ratio (-0.22 vs -0.75), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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