TLSA vs. TSLL
TLSA (Tiziana Life Sciences PLC) is a stock, while TSLL (Direxion Daily TSLA Bull 2X ETF) is Leveraged Equities fund actively managed by Direxion. Over the past 3 years, TLSA returned 15.87%/yr vs -7.94%/yr for TSLL. At a 0.09 correlation, their price movements are largely independent.
Performance
TLSA vs. TSLL - Performance Comparison
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Returns By Period
In the year-to-date period, TLSA achieves a -24.83% return, which is significantly higher than TSLL's -39.31% return.
TLSA
- 1D
- -3.45%
- 1M
- -24.32%
- YTD
- -24.83%
- 6M
- -26.80%
- 1Y
- -29.11%
- 3Y*
- 15.87%
- 5Y*
- -14.84%
- 10Y*
- —
TSLL
- 1D
- -3.38%
- 1M
- -24.58%
- YTD
- -39.31%
- 6M
- -48.10%
- 1Y
- -11.43%
- 3Y*
- -7.94%
- 5Y*
- —
- 10Y*
- —
TLSA vs. TSLL - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | |
|---|---|---|---|---|---|
TLSA Tiziana Life Sciences PLC | -24.83% | 114.02% | 24.32% | -6.43% | -18.01% |
TSLL Direxion Daily TSLA Bull 2X ETF | -39.31% | -26.80% | 99.63% | 139.86% | -74.99% |
Correlation
The correlation between TLSA and TSLL is 0.15, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.15 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.07 |
Correlation (All Time) Calculated using the full available price history since Aug 9, 2022 | 0.09 |
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Return for Risk
TLSA vs. TSLL — Risk / Return Rank
TLSA
TSLL
TLSA vs. TSLL - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Tiziana Life Sciences PLC (TLSA) and Direxion Daily TSLA Bull 2X ETF (TSLL). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| TLSA | TSLL | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -0.24 | ||
| Sortino ratioReturn per unit of downside risk | -0.50 | ||
| Omega ratioGain probability vs. loss probability | 0.99 | 1.05 | -0.06 |
| Calmar ratioReturn relative to maximum drawdown | -0.51 | -0.21 | -0.30 |
| Martin ratioReturn relative to average drawdown | -0.80 | -0.42 | -0.38 |
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Drawdowns
TLSA vs. TSLL - Drawdown Comparison
The maximum TLSA drawdown since its inception was -94.03%, which is greater than TSLL's maximum drawdown of -82.88%. Use the drawdown chart below to compare losses from any high point for TLSA and TSLL.
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Drawdown Indicators
| TLSA | TSLL | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -94.03% | -82.88% | -11.15% |
Max Drawdown (1Y)Largest decline over 1 year | -56.80% | -54.75% | -2.05% |
Max Drawdown (3Y)Largest decline over 3 years | -56.80% | -82.88% | +26.08% |
Max Drawdown (5Y)Largest decline over 5 years | -83.32% | — | — |
Current DrawdownCurrent decline from peak | -83.98% | -69.35% | -14.63% |
Average DrawdownAverage peak-to-trough decline | -70.36% | -53.93% | -16.43% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 36.36% | 27.51% | +8.85% |
Volatility
TLSA vs. TSLL - Volatility Comparison
The current volatility for Tiziana Life Sciences PLC (TLSA) is 19.69%, while Direxion Daily TSLA Bull 2X ETF (TSLL) has a volatility of 28.32%. This indicates that TLSA experiences smaller price fluctuations and is considered to be less risky than TSLL based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| TLSA | TSLL | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 19.69% | 28.32% | -8.63% |
Volatility (6M)Calculated over the trailing 6-month period | 53.43% | 56.74% | -3.31% |
Volatility (1Y)Calculated over the trailing 1-year period | 79.29% | 87.53% | -8.24% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 92.69% | 106.85% | -14.16% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 112.52% | 106.85% | +5.67% |
Dividends
TLSA vs. TSLL - Dividend Comparison
TLSA has not paid dividends to shareholders, while TSLL's dividend yield for the trailing twelve months is around 8.63%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
TLSA Tiziana Life Sciences PLC | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
TSLL Direxion Daily TSLA Bull 2X ETF | 8.63% | 5.00% | 2.47% | 4.44% | 1.57% |
Frequently Asked Questions
TLSA and TSLL have a correlation of 0.15, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
TSLL has higher volatility (28.32%) compared to TLSA (19.69%). In terms of maximum drawdown, TLSA dropped -94.03% vs TSLL's -82.88%.
TSLL currently has the higher Sharpe Ratio (-0.13 vs -0.37), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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