PDFDX vs. JAGLX

Last updated Jun 4, 2026

PDFDX (Perkins Discovery Fund) and JAGLX (Janus Henderson Global Life Sciences Fund Class T) are both Health & Biotech Equities funds. Over the past 10 years, PDFDX returned 9.82%/yr vs 10.81%/yr for JAGLX. A 0.60 correlation means they provide meaningful diversification when combined. PDFDX charges 2.50%/yr vs 0.92%/yr for JAGLX.

Performance

PDFDX vs. JAGLX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Perkins Discovery Fund (PDFDX) and Janus Henderson Global Life Sciences Fund Class T (JAGLX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, PDFDX achieves a 1.98% return, which is significantly higher than JAGLX's -3.64% return. Over the past 10 years, PDFDX has underperformed JAGLX with an annualized return of 9.82%, while JAGLX has yielded a comparatively higher 10.81% annualized return.

PDFDX

• 1D: -0.19%
• 1M: 5.46%
• YTD: 1.98%
• 6M: 2.97%
• 1Y: 31.05%
• 3Y*: 8.77%
• 5Y*: -4.76%
• 10Y*: 9.82%

JAGLX

• 1D: -2.63%
• 1M: -1.54%
• YTD: -3.64%
• 6M: -2.05%
• 1Y: 24.95%
• 3Y*: 10.94%
• 5Y*: 7.94%
• 10Y*: 10.81%

*Multi-year figures are annualized to reflect compound growth (CAGR)

PDFDX vs. JAGLX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
PDFDX Perkins Discovery Fund	1.98%	9.94%	19.19%	10.77%	-39.93%	2.11%	62.16%	15.01%	22.19%	11.58%
JAGLX Janus Henderson Global Life Sciences Fund Class T	-3.64%	24.72%	8.50%	7.41%	-2.79%	6.66%	25.52%	29.12%	4.05%	22.13%

Correlation

The correlation between PDFDX and JAGLX is 0.45, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.45
Correlation (3Y) Calculated over the trailing 3-year period	0.54
Correlation (5Y) Calculated over the trailing 5-year period	0.65
Correlation (10Y) Calculated over the trailing 10-year period	0.67
Correlation (All Time) Calculated using the full available price history since Jan 4, 1999	0.60

The correlation between PDFDX and JAGLX shifts across timeframes, from 0.45 (1 year) to 0.67 (10 years), reflecting how their relationship changes across market environments.

Return for Risk

PDFDX vs. JAGLX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PDFDX

PDFDX Risk / Return Rank: 19
PDFDX Sharpe Ratio Rank: 20
PDFDX Sortino Ratio Rank: 22
PDFDX Omega Ratio Rank: 18
PDFDX Calmar Ratio Rank: 18
PDFDX Martin Ratio Rank: 15

JAGLX

JAGLX Risk / Return Rank: 38
JAGLX Sharpe Ratio Rank: 35
JAGLX Sortino Ratio Rank: 36
JAGLX Omega Ratio Rank: 33
JAGLX Calmar Ratio Rank: 48
JAGLX Martin Ratio Rank: 38

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PDFDX vs. JAGLX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Perkins Discovery Fund (PDFDX) and Janus Henderson Global Life Sciences Fund Class T (JAGLX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PDFDX	JAGLX	Difference
Sharpe ratio: Return per unit of total volatility	1.29	1.72	-0.43
Sortino ratio: Return per unit of downside risk	2.00	2.52	-0.52
Omega ratio: Gain probability vs. loss probability	1.22	1.30	-0.08
Calmar ratio: Return relative to maximum drawdown	1.52	2.63	-1.11
Martin ratio: Return relative to average drawdown	4.28	8.39	-4.10
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PDFDX vs. JAGLX - Sharpe Ratio Comparison

The current PDFDX Sharpe Ratio is 1.29, which is comparable to the JAGLX Sharpe Ratio of 1.72. The chart below compares the historical Sharpe Ratios of PDFDX and JAGLX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	PDFDX	JAGLX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.29	1.72	-0.43
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.16	0.50	-0.66
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.34	0.62	-0.28
Sharpe Ratio (All Time) Calculated using the full available price history	0.38	0.58	-0.20

Drawdowns

PDFDX vs. JAGLX - Drawdown Comparison

The maximum PDFDX drawdown since its inception was -67.44%, which is greater than JAGLX's maximum drawdown of -58.96%. Use the drawdown chart below to compare losses from any high point for PDFDX and JAGLX.

Drawdown Indicators

	PDFDX	JAGLX	Difference
Max Drawdown Largest peak-to-trough decline	-67.44%	-58.96%	-8.48%
Max Drawdown (1Y) Largest decline over 1 year	-22.11%	-9.71%	-12.40%
Max Drawdown (3Y) Largest decline over 3 years	-31.75%	-17.41%	-14.34%
Max Drawdown (5Y) Largest decline over 5 years	-59.95%	-22.25%	-37.70%
Max Drawdown (10Y) Largest decline over 10 years	-62.70%	-27.38%	-35.32%
Current Drawdown Current decline from peak	-34.65%	-6.54%	-28.11%
Average Drawdown Average peak-to-trough decline	-25.72%	-17.43%	-8.29%
Ulcer Index Depth and duration of drawdowns from previous peaks	7.80%	3.03%	+4.77%

Volatility

PDFDX vs. JAGLX - Volatility Comparison

Perkins Discovery Fund (PDFDX) has a higher volatility of 6.50% compared to Janus Henderson Global Life Sciences Fund Class T (JAGLX) at 4.69%. This indicates that PDFDX's price experiences larger fluctuations and is considered to be riskier than JAGLX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PDFDX	JAGLX	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.50%	4.69%	+1.81%
Volatility (6M) Calculated over the trailing 6-month period	18.09%	10.95%	+7.14%
Volatility (1Y) Calculated over the trailing 1-year period	26.02%	14.85%	+11.17%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	29.80%	15.92%	+13.88%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	28.96%	17.41%	+11.55%

PDFDX vs. JAGLX - Expense Ratio Comparison

PDFDX has a 2.50% expense ratio, which is higher than JAGLX's 0.92% expense ratio.

Dividends

PDFDX vs. JAGLX - Dividend Comparison

PDFDX's dividend yield for the trailing twelve months is around 9.60%, more than JAGLX's 4.70% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
JAGLX Janus Henderson Global Life Sciences Fund Class T	4.70%	4.53%	10.98%	4.22%	0.14%	9.78%	7.75%	6.17%	13.38%	0.89%	1.13%	9.09%
PDFDX Perkins Discovery Fund	9.60%	4.25%	0.00%	0.00%	1.78%	31.11%	1.71%	0.00%	0.58%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both PDFDX and JAGLX in my portfolio?

PDFDX and JAGLX have a correlation of 0.45, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, PDFDX or JAGLX?

PDFDX has higher volatility (6.50%) compared to JAGLX (4.69%). In terms of maximum drawdown, PDFDX dropped -67.44% vs JAGLX's -58.96%.

Which has better risk-adjusted returns?

JAGLX currently has the higher Sharpe Ratio (1.72 vs 1.29), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.