OPK vs. BTAI

Last updated Apr 2, 2026

Compare and contrast key facts about OPKO Health, Inc. (OPK) and BioXcel Therapeutics, Inc. (BTAI).

Performance

OPK vs. BTAI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in OPKO Health, Inc. (OPK) and BioXcel Therapeutics, Inc. (BTAI). The values are adjusted to include any dividend payments, if applicable.

OPK vs. BTAI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
OPK OPKO Health, Inc.	-10.32%	-14.29%	-2.65%	20.80%	-74.01%	21.77%	168.71%	-51.16%	-9.34%
BTAI BioXcel Therapeutics, Inc.	-23.75%	-73.25%	-87.33%	-86.27%	5.66%	-56.00%	216.22%	278.50%	-65.00%

Fundamentals

EPS OPK : -$0.31 BTAI : -$6.19
PS Ratio OPK : 1.38 BTAI : 17.88
Total Revenue (TTM) OPK : $606.93M BTAI : $752.00K
Gross Profit (TTM) OPK : $251.79M BTAI : -$287.00K
EBITDA (TTM) OPK : -$66.36M BTAI : -$51.29M

Returns By Period

In the year-to-date period, OPK achieves a -10.32% return, which is significantly higher than BTAI's -23.75% return.

OPK

• 1D: -0.88%
• 1M: -8.87%
• YTD: -10.32%
• 6M: -27.10%
• 1Y: -31.93%
• 3Y*: -8.19%
• 5Y*: -23.74%
• 10Y*: -19.91%

BTAI

• 1D: -8.96%
• 1M: -25.15%
• YTD: -23.75%
• 6M: -52.53%
• 1Y: -36.46%
• 3Y*: -84.01%
• 5Y*: -71.07%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

OPK vs. BTAI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

OPK

OPK Risk / Return Rank: 8
OPK Sharpe Ratio Rank: 7
OPK Sortino Ratio Rank: 9
OPK Omega Ratio Rank: 11
OPK Calmar Ratio Rank: 5
OPK Martin Ratio Rank: 7

BTAI

BTAI Risk / Return Rank: 33
BTAI Sharpe Ratio Rank: 29
BTAI Sortino Ratio Rank: 44
BTAI Omega Ratio Rank: 41
BTAI Calmar Ratio Rank: 24
BTAI Martin Ratio Rank: 28

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

OPK vs. BTAI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for OPKO Health, Inc. (OPK) and BioXcel Therapeutics, Inc. (BTAI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	OPK	BTAI	Difference
Sharpe ratio Return per unit of total volatility	-0.85	-0.25	-0.60
Sortino ratio Return per unit of downside risk	-1.16	0.61	-1.77
Omega ratio Gain probability vs. loss probability	0.87	1.07	-0.20
Calmar ratio Return relative to maximum drawdown	-0.95	-0.49	-0.46
Martin ratio Return relative to average drawdown	-1.58	-0.72	-0.86
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

OPK vs. BTAI - Sharpe Ratio Comparison

The current OPK Sharpe Ratio is -0.85, which is lower than the BTAI Sharpe Ratio of -0.25. The chart below compares the historical Sharpe Ratios of OPK and BTAI, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	OPK	BTAI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.85	-0.25	-0.60
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.42	-0.59	+0.17
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.31	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.05	-0.39	+0.33

Correlation

The correlation between OPK and BTAI is 0.26, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

OPK vs. BTAI - Dividend Comparison

Neither OPK nor BTAI has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

OPK vs. BTAI - Drawdown Comparison

The maximum OPK drawdown since its inception was -98.17%, roughly equal to the maximum BTAI drawdown of -99.89%. Use the drawdown chart below to compare losses from any high point for OPK and BTAI.

Drawdown Indicators

	OPK	BTAI	Difference
Max Drawdown Largest peak-to-trough decline	-98.17%	-99.89%	+1.72%
Max Drawdown (1Y) Largest decline over 1 year	-33.33%	-82.21%	+48.88%
Max Drawdown (5Y) Largest decline over 5 years	-83.19%	-99.81%	+16.62%
Max Drawdown (10Y) Largest decline over 10 years	-92.73%	—	—
Current Drawdown Current decline from peak	-94.09%	-99.88%	+5.79%
Average Drawdown Average peak-to-trough decline	-72.98%	-62.41%	-10.57%
Ulcer Index Depth and duration of drawdowns from previous peaks	20.20%	55.34%	-35.14%

Volatility

OPK vs. BTAI - Volatility Comparison

The current volatility for OPKO Health, Inc. (OPK) is 11.51%, while BioXcel Therapeutics, Inc. (BTAI) has a volatility of 31.72%. This indicates that OPK experiences smaller price fluctuations and is considered to be less risky than BTAI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	OPK	BTAI	Difference
Volatility (1M) Calculated over the trailing 1-month period	11.51%	31.72%	-20.21%
Volatility (6M) Calculated over the trailing 6-month period	23.80%	59.34%	-35.54%
Volatility (1Y) Calculated over the trailing 1-year period	37.83%	146.44%	-108.61%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	56.59%	120.91%	-64.32%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	64.66%	118.72%	-54.06%

Financials