OPK vs. BTAI

Last updated Jun 24, 2026

OPK (OPKO Health, Inc.) and BTAI (BioXcel Therapeutics, Inc.) are both stocks. Both are in the Healthcare sector — OPK in Diagnostics & Research, BTAI in Biotechnology. Over the past 5 years, OPK returned -17.28%/yr vs -69.75%/yr for BTAI. At a 0.26 correlation, their price movements are largely independent.

Performance

OPK vs. BTAI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in OPKO Health, Inc. (OPK) and BioXcel Therapeutics, Inc. (BTAI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, OPK achieves a 15.87% return, which is significantly higher than BTAI's -21.25% return.

OPK

• 1D: 2.10%
• 1M: 14.96%
• YTD: 15.87%
• 6M: 11.45%
• 1Y: 14.96%
• 3Y*: -3.01%
• 5Y*: -17.28%
• 10Y*: -17.04%

BTAI

• 1D: -3.08%
• 1M: 11.50%
• YTD: -21.25%
• 6M: -27.17%
• 1Y: -23.64%
• 3Y*: -83.89%
• 5Y*: -69.75%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

OPK vs. BTAI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
OPK OPKO Health, Inc.	15.87%	-14.29%	-2.65%	20.80%	-74.01%	21.77%	168.71%	-51.16%	-9.61%
BTAI BioXcel Therapeutics, Inc.	-21.25%	-73.25%	-87.33%	-86.27%	5.66%	-56.00%	216.22%	278.50%	-64.97%

Correlation

The correlation between OPK and BTAI is 0.14, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.14
Correlation (3Y) Calculated over the trailing 3-year period	0.15
Correlation (5Y) Calculated over the trailing 5-year period	0.26
Correlation (All Time) Calculated using the full available price history since Mar 8, 2018	0.26

The correlation between OPK and BTAI shifts across timeframes, from 0.14 (1 year) to 0.26 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap OPK : $1.11B BTAI : $29.70M
EPS OPK : -$0.29 BTAI : -$5.21
PS Ratio OPK : 1.87 BTAI : 26.78
Total Revenue (TTM) OPK : $581.17M BTAI : $680.00K
Gross Profit (TTM) OPK : $277.22M BTAI : $175.00K
EBITDA (TTM) OPK : -$65.07M BTAI : -$61.68M

Return for Risk

OPK vs. BTAI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

OPK

OPK Risk / Return Rank: 53
OPK Sharpe Ratio Rank: 57
OPK Sortino Ratio Rank: 52
OPK Omega Ratio Rank: 51
OPK Calmar Ratio Rank: 54
OPK Martin Ratio Rank: 53

BTAI

BTAI Risk / Return Rank: 41
BTAI Sharpe Ratio Rank: 36
BTAI Sortino Ratio Rank: 52
BTAI Omega Ratio Rank: 49
BTAI Calmar Ratio Rank: 33
BTAI Martin Ratio Rank: 36

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

OPK vs. BTAI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for OPKO Health, Inc. (OPK) and BioXcel Therapeutics, Inc. (BTAI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	OPK	BTAI	Difference
Sharpe ratio: Return per unit of total volatility	0.40	-0.17	+0.57
Sortino ratio: Return per unit of downside risk	0.85	0.81	+0.04
Omega ratio: Gain probability vs. loss probability	1.10	1.09	+0.01
Calmar ratio: Return relative to maximum drawdown	0.49	-0.28	+0.77
Martin ratio: Return relative to average drawdown	0.89	-0.35	+1.24

OPK vs. BTAI - Sharpe Ratio Comparison

The current OPK Sharpe Ratio is 0.40, which is higher than the BTAI Sharpe Ratio of -0.17. The chart below compares the historical Sharpe Ratios of OPK and BTAI, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

OPK vs. BTAI - Drawdown Comparison

The maximum OPK drawdown since its inception was -98.17%, roughly equal to the maximum BTAI drawdown of -99.90%. Use the drawdown chart below to compare losses from any high point for OPK and BTAI.

Drawdown Indicators

	OPK	BTAI	Difference
Max Drawdown Largest peak-to-trough decline	-98.17%	-99.90%	+1.73%
Max Drawdown (1Y) Largest decline over 1 year	-30.38%	-85.00%	+54.62%
Max Drawdown (3Y) Largest decline over 3 years	-60.12%	-99.66%	+39.54%
Max Drawdown (5Y) Largest decline over 5 years	-83.19%	-99.82%	+16.63%
Max Drawdown (10Y) Largest decline over 10 years	-92.73%	—	—
Current Drawdown Current decline from peak	-92.36%	-99.88%	+7.52%
Average Drawdown Average peak-to-trough decline	-73.12%	-63.39%	-9.73%
Ulcer Index Depth and duration of drawdowns from previous peaks	16.92%	67.05%	-50.13%

Volatility

OPK vs. BTAI - Volatility Comparison

The current volatility for OPKO Health, Inc. (OPK) is 12.27%, while BioXcel Therapeutics, Inc. (BTAI) has a volatility of 21.69%. This indicates that OPK experiences smaller price fluctuations and is considered to be less risky than BTAI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	OPK	BTAI	Difference
Volatility (1M) Calculated over the trailing 1-month period	12.27%	21.69%	-9.42%
Volatility (6M) Calculated over the trailing 6-month period	26.48%	55.13%	-28.65%
Volatility (1Y) Calculated over the trailing 1-year period	37.61%	141.19%	-103.58%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	56.33%	121.41%	-65.08%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	64.73%	117.69%	-52.96%

Dividends

OPK vs. BTAI - Dividend Comparison

Neither OPK nor BTAI has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both OPK and BTAI in my portfolio?

OPK and BTAI have a correlation of 0.14, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, OPK or BTAI?

BTAI has higher volatility (21.69%) compared to OPK (12.27%). In terms of maximum drawdown, OPK dropped -98.17% vs BTAI's -99.90%.

Which has better risk-adjusted returns?

OPK currently has the higher Sharpe Ratio (0.40 vs -0.17), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.