BTAI vs. VOO

Last updated Aug 1, 2026

BTAI (BioXcel Therapeutics, Inc.) is a stock, while VOO (Vanguard S&P 500 ETF) is S&P 500 fund tracking the S&P 500 Index. Over the past 5 years, BTAI returned -71.22%/yr vs 12.83%/yr for VOO. Their 0.31 correlation means their historical movements had little consistent relationship.

Performance

BTAI vs. VOO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in BioXcel Therapeutics, Inc. (BTAI) and Vanguard S&P 500 ETF (VOO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, BTAI achieves a -49.50% return, which is significantly lower than VOO's 10.16% return.

BTAI

• 1D: 1.92%
• 1M: -41.45%
• 6M: -49.18%
• YTD: -49.50%
• 1Y: -41.02%
• 3Y*: -81.12%
• 5Y*: -71.22%
• 10Y*: —
• ALL TIME*: -47.34%

VOO

• 1D: 0.71%
• 1M: 0.26%
• 6M: 8.58%
• YTD: 10.16%
• 1Y: 21.58%
• 3Y*: 19.42%
• 5Y*: 12.83%
• 10Y*: 15.14%
• ALL TIME*: 14.78%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
BTAI BioXcel Therapeutics, Inc.	$325.05K	$1.33M	$967.87K
VOO Vanguard S&P 500 ETF	$3.82B	$3.78B	$5.44B

BTAI vs. VOO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
BTAI BioXcel Therapeutics, Inc.	-49.50%	-73.25%	-87.33%	-86.27%	5.66%	-56.00%	216.22%	278.50%	-64.97%
VOO Vanguard S&P 500 ETF	10.16%	17.82%	24.98%	26.32%	-18.17%	28.79%	18.32%	31.37%	-6.57%

Correlation

The correlation between BTAI and VOO is 0.25, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.25
Correlation (3Y) Balances recent behavior with more history.	0.29
Correlation (5Y) Shows whether the relationship held over a longer period.	0.33
Correlation (All Time) Calculated using the full available price history since Mar 8, 2018	0.31

Return for Risk

BTAI vs. VOO — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

BTAI

BTAI Risk / Return Rank: 38
BTAI Sharpe Ratio Rank: 33
BTAI Sortino Ratio Rank: 46
BTAI Omega Ratio Rank: 46
BTAI Calmar Ratio Rank: 29
BTAI Martin Ratio Rank: 34

VOO

VOO Risk / Return Rank: 68
VOO Sharpe Ratio Rank: 68
VOO Sortino Ratio Rank: 65
VOO Omega Ratio Rank: 66
VOO Calmar Ratio Rank: 64
VOO Martin Ratio Rank: 76

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

BTAI vs. VOO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for BioXcel Therapeutics, Inc. (BTAI) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	BTAI	VOO	Difference
Sharpe ratio: Return per unit of total volatility	-0.27	1.53	-1.80
Sortino ratio: Return per unit of downside risk	0.52	2.13	-1.61
Omega ratio: Gain probability vs. loss probability	1.06	1.28	-0.21
Calmar ratio: Return relative to maximum drawdown	-0.44	2.21	-2.64
Martin ratio: Return relative to average drawdown	-0.53	9.44	-9.97

BTAI vs. VOO - Sharpe Ratio Comparison

The current BTAI Sharpe Ratio is -0.27, which is lower than the VOO Sharpe Ratio of 1.53. The chart below compares the historical Sharpe Ratios of BTAI and VOO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

BTAI vs. VOO - Drawdown Comparison

The maximum BTAI drawdown since its inception was -99.92%, which is greater than VOO's maximum drawdown of -33.99%. Use the drawdown chart below to compare losses from any high point for BTAI and VOO.

Drawdown Indicators

	BTAI	VOO	Difference
Max Drawdown Largest peak-to-trough decline	-99.92%	-33.99%	-65.93%
Max Drawdown (1Y) Largest decline over 1 year	-88.34%	-8.90%	-79.44%
Max Drawdown (3Y) Largest decline over 3 years	-99.34%	-18.69%	-80.65%
Max Drawdown (5Y) Largest decline over 5 years	-99.86%	-24.52%	-75.34%
Max Drawdown (10Y) Largest decline over 10 years	—	-33.99%	—
Current Drawdown Current decline from peak	-99.92%	-1.38%	-98.54%
Average Drawdown Average peak-to-trough decline	-63.86%	-3.67%	-60.19%
Ulcer Index Depth and duration of drawdowns from previous peaks	72.48%	2.08%	+70.40%

Volatility

BTAI vs. VOO - Volatility Comparison

BioXcel Therapeutics, Inc. (BTAI) has a higher volatility of 41.37% compared to Vanguard S&P 500 ETF (VOO) at 3.54%. This indicates that BTAI's price experiences larger fluctuations and is considered to be riskier than VOO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	BTAI	VOO	Difference
Volatility (1M) Calculated over the trailing 1-month period	41.37%	3.54%	+37.83%
Volatility (6M) Calculated over the trailing 6-month period	66.00%	10.10%	+55.90%
Volatility (1Y) Calculated over the trailing 1-year period	143.67%	12.82%	+130.85%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	122.54%	16.93%	+105.61%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	117.77%	18.01%	+99.76%

Dividends

BTAI vs. VOO - Dividend Comparison

BTAI has not paid dividends to shareholders, while VOO's dividend yield for the trailing twelve months is around 1.07%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
BTAI BioXcel Therapeutics, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
VOO Vanguard S&P 500 ETF	1.07%	1.13%	1.24%	1.46%	1.69%	1.25%	1.54%	1.88%	2.06%	1.78%	2.02%	2.10%

Frequently Asked Questions

Can I hold both BTAI and VOO in my portfolio?

BTAI and VOO have a correlation of 0.25, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, BTAI or VOO?

BTAI has higher volatility (41.37%) compared to VOO (3.54%). In terms of maximum drawdown, BTAI dropped -99.92% vs VOO's -33.99%.

Which has better risk-adjusted returns?

VOO currently has the higher Sharpe Ratio (1.53 vs -0.27), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.