OPK vs. ACON

Last updated Jun 4, 2026

OPK (OPKO Health, Inc.) and ACON (Aclarion Inc) are both stocks. Both are in the Healthcare sector — OPK in Diagnostics & Research, ACON in Health Information Services. Over the past 3 years, OPK returned 0.23%/yr vs -97.13%/yr for ACON. At a 0.09 correlation, their price movements are largely independent.

Performance

OPK vs. ACON - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in OPKO Health, Inc. (OPK) and Aclarion Inc (ACON). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, OPK achieves a 15.87% return, which is significantly higher than ACON's -24.13% return.

OPK

• 1D: 4.29%
• 1M: 31.53%
• YTD: 15.87%
• 6M: 6.57%
• 1Y: 5.80%
• 3Y*: 0.23%
• 5Y*: -16.56%
• 10Y*: -17.51%

ACON

• 1D: -0.29%
• 1M: 5.44%
• YTD: -24.13%
• 6M: -46.96%
• 1Y: -45.89%
• 3Y*: -97.13%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

OPK vs. ACON - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
OPK OPKO Health, Inc.	15.87%	-14.29%	-2.65%	20.80%	-57.34%
ACON Aclarion Inc	-24.13%	-99.65%	-95.50%	-65.52%	-78.68%

Correlation

The correlation between OPK and ACON is 0.07, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.07
Correlation (3Y) Calculated over the trailing 3-year period	0.07
Correlation (All Time) Calculated using the full available price history since Apr 25, 2022	0.09

Fundamentals

Market Cap OPK : $1.11B ACON : $7.43M
EPS OPK : -$0.29 ACON : -$8.41
PS Ratio OPK : 1.87 ACON : 42.87
PB Ratio OPK : 0.92 ACON : 0.38
Total Revenue (TTM) OPK : $581.17M ACON : $77.88K
Gross Profit (TTM) OPK : $277.22M ACON : -$212.34K
EBITDA (TTM) OPK : -$65.07M ACON : -$8.11M

Return for Risk

OPK vs. ACON — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

OPK

OPK Risk / Return Rank: 44
OPK Sharpe Ratio Rank: 46
OPK Sortino Ratio Rank: 42
OPK Omega Ratio Rank: 42
OPK Calmar Ratio Rank: 45
OPK Martin Ratio Rank: 45

ACON

ACON Risk / Return Rank: 21
ACON Sharpe Ratio Rank: 19
ACON Sortino Ratio Rank: 24
ACON Omega Ratio Rank: 23
ACON Calmar Ratio Rank: 19
ACON Martin Ratio Rank: 20

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

OPK vs. ACON - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for OPKO Health, Inc. (OPK) and Aclarion Inc (ACON). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	OPK	ACON	Difference
Sharpe ratio Return per unit of total volatility	0.15	-0.50	+0.65
Sortino ratio Return per unit of downside risk	0.51	-0.27	+0.78
Omega ratio Gain probability vs. loss probability	1.06	0.96	+0.10
Calmar ratio Return relative to maximum drawdown	0.19	-0.61	+0.80
Martin ratio Return relative to average drawdown	0.35	-1.02	+1.36
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

OPK vs. ACON - Sharpe Ratio Comparison

The current OPK Sharpe Ratio is 0.15, which is higher than the ACON Sharpe Ratio of -0.50. The chart below compares the historical Sharpe Ratios of OPK and ACON, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	OPK	ACON	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.15	-0.50	+0.65
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.29	—	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.27	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.04	-0.54	+0.50

Drawdowns

OPK vs. ACON - Drawdown Comparison

The maximum OPK drawdown since its inception was -98.17%, roughly equal to the maximum ACON drawdown of -100.00%. Use the drawdown chart below to compare losses from any high point for OPK and ACON.

Drawdown Indicators

	OPK	ACON	Difference
Max Drawdown Largest peak-to-trough decline	-98.17%	-100.00%	+1.83%
Max Drawdown (1Y) Largest decline over 1 year	-30.38%	-75.64%	+45.26%
Max Drawdown (3Y) Largest decline over 3 years	-60.12%	-100.00%	+39.88%
Max Drawdown (5Y) Largest decline over 5 years	-83.19%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-92.73%	—	—
Current Drawdown Current decline from peak	-92.36%	-100.00%	+7.64%
Average Drawdown Average peak-to-trough decline	-73.10%	-87.87%	+14.77%
Ulcer Index Depth and duration of drawdowns from previous peaks	16.83%	45.23%	-28.40%

Volatility

OPK vs. ACON - Volatility Comparison

OPKO Health, Inc. (OPK) has a higher volatility of 13.93% compared to Aclarion Inc (ACON) at 11.02%. This indicates that OPK's price experiences larger fluctuations and is considered to be riskier than ACON based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	OPK	ACON	Difference
Volatility (1M) Calculated over the trailing 1-month period	13.93%	11.02%	+2.91%
Volatility (6M) Calculated over the trailing 6-month period	26.91%	86.02%	-59.11%
Volatility (1Y) Calculated over the trailing 1-year period	37.75%	92.35%	-54.60%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	56.45%	173.04%	-116.59%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	64.77%	173.04%	-108.27%

Dividends

OPK vs. ACON - Dividend Comparison

Neither OPK nor ACON has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both OPK and ACON in my portfolio?

OPK and ACON have a correlation of 0.07, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, OPK or ACON?

OPK has higher volatility (13.93%) compared to ACON (11.02%). In terms of maximum drawdown, OPK dropped -98.17% vs ACON's -100.00%.

Which has better risk-adjusted returns?

OPK currently has the higher Sharpe Ratio (0.15 vs -0.50), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.