NTRA vs. ZYME

Last updated Jun 24, 2026

NTRA (Natera, Inc.) and ZYME (Zymeworks Inc.) are both stocks. Both are in the Healthcare sector — NTRA in Diagnostics & Research, ZYME in Biotechnology. Over the past 5 years, NTRA returned 14.42%/yr vs -8.24%/yr for ZYME. At a 0.29 correlation, their price movements are largely independent.

Performance

NTRA vs. ZYME - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Natera, Inc. (NTRA) and Zymeworks Inc. (ZYME). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, NTRA achieves a 2.48% return, which is significantly higher than ZYME's -9.30% return.

NTRA

• 1D: 2.60%
• 1M: 15.54%
• YTD: 2.48%
• 6M: -0.27%
• 1Y: 37.79%
• 3Y*: 65.95%
• 5Y*: 14.42%
• 10Y*: 33.08%

ZYME

• 1D: 2.67%
• 1M: -6.76%
• YTD: -9.30%
• 6M: -10.86%
• 1Y: 91.50%
• 3Y*: 43.33%
• 5Y*: -8.24%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

NTRA vs. ZYME - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
NTRA Natera, Inc.	2.48%	44.72%	152.71%	55.94%	-56.99%	-6.16%	195.40%	141.33%	55.28%	-0.11%
ZYME Zymeworks Inc.	-9.30%	79.85%	40.90%	32.19%	-52.04%	-65.32%	3.96%	209.67%	93.33%	-43.75%

Correlation

The correlation between NTRA and ZYME is 0.28, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.28
Correlation (3Y) Calculated over the trailing 3-year period	0.31
Correlation (5Y) Calculated over the trailing 5-year period	0.31
Correlation (All Time) Calculated using the full available price history since Apr 28, 2017	0.29

Fundamentals

Market Cap NTRA : $33.22B ZYME : $1.78B
EPS NTRA : -$1.64 ZYME : -$583.41
PS Ratio NTRA : 12.95 ZYME : 22.95
PB Ratio NTRA : 18.73 ZYME : 0.01
Total Revenue (TTM) NTRA : $2.50B ZYME : $78.86M
Gross Profit (TTM) NTRA : $1.63B ZYME : $77.16M
EBITDA (TTM) NTRA : -$294.86M ZYME : -$47.18B

Return for Risk

NTRA vs. ZYME — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

NTRA

NTRA Risk / Return Rank: 66
NTRA Sharpe Ratio Rank: 70
NTRA Sortino Ratio Rank: 64
NTRA Omega Ratio Rank: 63
NTRA Calmar Ratio Rank: 68
NTRA Martin Ratio Rank: 67

ZYME

ZYME Risk / Return Rank: 87
ZYME Sharpe Ratio Rank: 86
ZYME Sortino Ratio Rank: 86
ZYME Omega Ratio Rank: 84
ZYME Calmar Ratio Rank: 90
ZYME Martin Ratio Rank: 87

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

NTRA vs. ZYME - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Natera, Inc. (NTRA) and Zymeworks Inc. (ZYME). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	NTRA	ZYME	Difference
Sharpe ratio: Return per unit of total volatility	0.88	1.74	-0.86
Sortino ratio: Return per unit of downside risk	1.37	2.69	-1.32
Omega ratio: Gain probability vs. loss probability	1.17	1.33	-0.16
Calmar ratio: Return relative to maximum drawdown	1.35	4.33	-2.98
Martin ratio: Return relative to average drawdown	2.80	9.21	-6.40

NTRA vs. ZYME - Sharpe Ratio Comparison

The current NTRA Sharpe Ratio is 0.88, which is lower than the ZYME Sharpe Ratio of 1.74. The chart below compares the historical Sharpe Ratios of NTRA and ZYME, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

NTRA vs. ZYME - Drawdown Comparison

The maximum NTRA drawdown since its inception was -77.74%, smaller than the maximum ZYME drawdown of -91.81%. Use the drawdown chart below to compare losses from any high point for NTRA and ZYME.

Drawdown Indicators

	NTRA	ZYME	Difference
Max Drawdown Largest peak-to-trough decline	-77.74%	-91.81%	+14.07%
Max Drawdown (1Y) Largest decline over 1 year	-28.20%	-21.25%	-6.95%
Max Drawdown (3Y) Largest decline over 3 years	-39.94%	-45.75%	+5.81%
Max Drawdown (5Y) Largest decline over 5 years	-77.74%	-87.53%	+9.79%
Max Drawdown (10Y) Largest decline over 10 years	-77.74%	—	—
Current Drawdown Current decline from peak	-7.72%	-57.97%	+50.25%
Average Drawdown Average peak-to-trough decline	-33.38%	-52.54%	+19.16%
Ulcer Index Depth and duration of drawdowns from previous peaks	13.52%	9.97%	+3.55%

Volatility

NTRA vs. ZYME - Volatility Comparison

Natera, Inc. (NTRA) has a higher volatility of 12.58% compared to Zymeworks Inc. (ZYME) at 10.12%. This indicates that NTRA's price experiences larger fluctuations and is considered to be riskier than ZYME based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	NTRA	ZYME	Difference
Volatility (1M) Calculated over the trailing 1-month period	12.58%	10.12%	+2.46%
Volatility (6M) Calculated over the trailing 6-month period	35.53%	29.45%	+6.08%
Volatility (1Y) Calculated over the trailing 1-year period	43.14%	52.91%	-9.77%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	57.02%	61.85%	-4.83%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	60.82%	61.45%	-0.63%

Dividends

NTRA vs. ZYME - Dividend Comparison

Neither NTRA nor ZYME has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both NTRA and ZYME in my portfolio?

NTRA and ZYME have a correlation of 0.28, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, NTRA or ZYME?

NTRA has higher volatility (12.58%) compared to ZYME (10.12%). In terms of maximum drawdown, NTRA dropped -77.74% vs ZYME's -91.81%.

Which has better risk-adjusted returns?

ZYME currently has the higher Sharpe Ratio (1.74 vs 0.88), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.