MREO vs. ISRG

Last updated Jun 4, 2026

MREO (Mereo BioPharma Group plc) and ISRG (Intuitive Surgical, Inc.) are both stocks. Both are in the Healthcare sector — MREO in Biotechnology, ISRG in Medical Instruments & Supplies. Over the past 5 years, MREO returned -37.84%/yr vs 8.00%/yr for ISRG. At a 0.19 correlation, their price movements are largely independent.

Performance

MREO vs. ISRG - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Mereo BioPharma Group plc (MREO) and Intuitive Surgical, Inc. (ISRG). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, MREO achieves a -19.80% return, which is significantly higher than ISRG's -28.09% return.

MREO

• 1D: -1.53%
• 1M: 16.41%
• YTD: -19.80%
• 6M: -82.95%
• 1Y: -87.39%
• 3Y*: -31.94%
• 5Y*: -37.84%
• 10Y*: —

ISRG

• 1D: 1.24%
• 1M: -9.96%
• YTD: -28.09%
• 6M: -28.51%
• 1Y: -26.20%
• 3Y*: 9.27%
• 5Y*: 8.00%
• 10Y*: 19.13%

*Multi-year figures are annualized to reflect compound growth (CAGR)

MREO vs. ISRG - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
MREO Mereo BioPharma Group plc	-19.80%	-88.09%	51.52%	208.00%	-53.12%	-55.31%	9.15%	-49.54%
ISRG Intuitive Surgical, Inc.	-28.09%	8.51%	54.72%	27.14%	-26.15%	31.76%	38.39%	16.34%

Correlation

The correlation between MREO and ISRG is 0.21, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.21
Correlation (3Y) Calculated over the trailing 3-year period	0.20
Correlation (5Y) Calculated over the trailing 5-year period	0.22
Correlation (All Time) Calculated using the full available price history since Apr 25, 2019	0.19

Fundamentals

Market Cap MREO : $53.59M ISRG : $146.54B
EPS MREO : -$0.22 ISRG : $8.24
PS Ratio MREO : 106.89 ISRG : 13.91
PB Ratio MREO : 1.57 ISRG : 8.33
Total Revenue (TTM) MREO : $500.00K ISRG : $10.58B
Gross Profit (TTM) MREO : $366.00K ISRG : $7.02B
EBITDA (TTM) MREO : -$39.61M ISRG : $3.76B

Return for Risk

MREO vs. ISRG — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

MREO

MREO Risk / Return Rank: 14
MREO Sharpe Ratio Rank: 13
MREO Sortino Ratio Rank: 24
MREO Omega Ratio Rank: 20
MREO Calmar Ratio Rank: 4
MREO Martin Ratio Rank: 8

ISRG

ISRG Risk / Return Rank: 8
ISRG Sharpe Ratio Rank: 7
ISRG Sortino Ratio Rank: 8
ISRG Omega Ratio Rank: 10
ISRG Calmar Ratio Rank: 9
ISRG Martin Ratio Rank: 3

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

MREO vs. ISRG - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Mereo BioPharma Group plc (MREO) and Intuitive Surgical, Inc. (ISRG). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	MREO	ISRG	Difference
Sharpe ratio Return per unit of total volatility	-0.65	-0.85	+0.20
Sortino ratio Return per unit of downside risk	-0.30	-1.23	+0.93
Omega ratio Gain probability vs. loss probability	0.94	0.86	+0.08
Calmar ratio Return relative to maximum drawdown	-0.95	-0.82	-0.13
Martin ratio Return relative to average drawdown	-1.39	-1.65	+0.26
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

MREO vs. ISRG - Sharpe Ratio Comparison

The current MREO Sharpe Ratio is -0.65, which is comparable to the ISRG Sharpe Ratio of -0.85. The chart below compares the historical Sharpe Ratios of MREO and ISRG, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	MREO	ISRG	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.65	-0.85	+0.20
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.38	0.24	-0.62
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.59	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.30	0.47	-0.77

Drawdowns

MREO vs. ISRG - Drawdown Comparison

The maximum MREO drawdown since its inception was -96.35%, which is greater than ISRG's maximum drawdown of -82.26%. Use the drawdown chart below to compare losses from any high point for MREO and ISRG.

Drawdown Indicators

	MREO	ISRG	Difference
Max Drawdown Largest peak-to-trough decline	-96.35%	-82.26%	-14.09%
Max Drawdown (1Y) Largest decline over 1 year	-91.93%	-32.14%	-59.79%
Max Drawdown (3Y) Largest decline over 3 years	-95.13%	-34.10%	-61.03%
Max Drawdown (5Y) Largest decline over 5 years	-95.13%	-49.90%	-45.23%
Max Drawdown (10Y) Largest decline over 10 years	—	-49.90%	—
Current Drawdown Current decline from peak	-94.86%	-33.28%	-61.58%
Average Drawdown Average peak-to-trough decline	-65.90%	-21.27%	-44.63%
Ulcer Index Depth and duration of drawdowns from previous peaks	62.66%	15.91%	+46.75%

Volatility

MREO vs. ISRG - Volatility Comparison

Mereo BioPharma Group plc (MREO) has a higher volatility of 36.10% compared to Intuitive Surgical, Inc. (ISRG) at 11.07%. This indicates that MREO's price experiences larger fluctuations and is considered to be riskier than ISRG based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	MREO	ISRG	Difference
Volatility (1M) Calculated over the trailing 1-month period	36.10%	11.07%	+25.03%
Volatility (6M) Calculated over the trailing 6-month period	224.43%	20.23%	+204.20%
Volatility (1Y) Calculated over the trailing 1-year period	134.18%	30.83%	+103.35%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	100.56%	33.15%	+67.41%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	113.66%	32.38%	+81.28%

Dividends

MREO vs. ISRG - Dividend Comparison

Neither MREO nor ISRG has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both MREO and ISRG in my portfolio?

MREO and ISRG have a correlation of 0.21, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, MREO or ISRG?

MREO has higher volatility (36.10%) compared to ISRG (11.07%). In terms of maximum drawdown, MREO dropped -96.35% vs ISRG's -82.26%.

Which has better risk-adjusted returns?

MREO currently has the higher Sharpe Ratio (-0.65 vs -0.85), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.