- ISIN
- US5894921072
- CUSIP
- 589492107
- Sector
- Healthcare
- Industry
- Biotechnology
- IPO Date
- Apr 24, 2019
Highlights
- Market Cap
- $54.70M
- Enterprise Value
- $18.48M
- EPS (TTM)
- -$0.22
- Total Revenue (TTM)
- $500.00K
- Gross Profit (TTM)
- $366.00K
- EBITDA (TTM)
- -$39.61M
- Year Range
- $0.20 - $2.37
- Target Price
- $0.83
- ROA (TTM)
- -87.93%
- ROE (TTM)
- -104.86%
- Avg. Volume (1M)
- 1M
- Avg. Volume Value (1M)
- $338.89K
Share Price Chart
Loading charts...
Compare stocks, funds, or ETFs
Search for stocks, ETFs, and funds for a quick comparison or use the comparison tool for more options.
Performance
MREO Performance Chart
Mereo BioPharma Group plc (MREO) is down 17.8% since the beginning of the year. At $0 per share, MREO is trading 85.5% below its 52-week high of $2. Investors who bought $1,000 worth of MREO shares 5 years ago would now be looking at an investment worth $133.
Loading charts...
Compare this symbol against anything
Returns By Period
Mereo BioPharma Group plc (MREO) has returned -17.76% so far this year and -79.36% over the past 12 months.
Mereo BioPharma Group plc
- 1D
- 8.79%
- 1M
- 2.39%
- 6M
- -22.11%
- YTD
- -17.76%
- 1Y
- -79.36%
- 3Y*
- -36.68%
- 5Y*
- -33.17%
- 10Y*
- —
- ALL TIME*
- -30.49%
Benchmark (S&P 500 Index)
- 1D
- 0.70%
- 1M
- 0.09%
- 6M
- 7.94%
- YTD
- 9.41%
- 1Y
- 20.07%
- 3Y*
- 17.84%
- 5Y*
- 11.25%
- 10Y*
- 13.26%
- ALL TIME*
- 8.09%
MREO Monthly Returns History
Based on dividend-adjusted daily data since Apr 24, 2019, MREO's average daily return is +0.13%, while the average monthly return is +1.45%. At this rate, an investment would double in approximately 4.0 years.
Historically, 43% of months were positive and 57% were negative. The best month was Jun 2020 with a return of +140.9%, while the worst month was Dec 2025 at -77.7%. The longest winning streak lasted 5 consecutive months, and the longest losing streak was 9 months.
On a daily basis, MREO closed higher 44% of trading days. The best single day was Dec 26, 2019 with a return of +95.5%, while the worst single day was Dec 29, 2025 at -87.7%.
| Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec | Total | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026 | 5.59% | -15.77% | -10.96% | -18.67% | 28.17% | -7.65% | 7.87% | -17.76% | |||||
| 2025 | -14.00% | -20.27% | -6.25% | 15.11% | -16.99% | 26.05% | -37.64% | 1.18% | 20.47% | -7.77% | -1.58% | -77.72% | -88.09% |
| 2024 | 64.07% | 0.26% | -13.16% | -7.58% | 13.11% | 4.35% | 12.78% | 15.52% | -12.37% | 2.43% | -14.37% | -2.91% | 51.52% |
| 2023 | 24.68% | -4.57% | -20.79% | 85.32% | -22.90% | 30.69% | 0.76% | 3.01% | -5.84% | 55.43% | 4.24% | 10.53% | 208.00% |
| 2022 | -18.13% | -5.34% | -9.68% | -44.65% | -18.47% | 121.61% | 8.04% | -0.83% | -28.24% | 16.12% | -21.18% | -4.83% | -53.12% |
| 2021 | -24.02% | 43.01% | -13.37% | 5.34% | -7.89% | -3.06% | -18.93% | 8.56% | -13.26% | -7.02% | -21.78% | -9.09% | -55.31% |
Benchmark Metrics
Mereo BioPharma Group plc has an annualized alpha of 18.88%, beta of 1.11, and R2 of 0.04 versus S&P 500 Index. Calculated based on daily prices since April 24, 2019.
- This stock participated in 207.59% of S&P 500 Index downside but only 59.55% of its upside - more exposed to losses than it benefited from rallies.
- R2 of 0.04 means this stock moves largely independently of S&P 500 Index - capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.
- Alpha
- 18.88%
- Beta
- 1.11
- R²
- 0.04
- Upside Capture
- 59.55%
- Downside Capture
- 207.59%
Return for Risk
Risk / Return Rank
MREO ranks 21 for risk / return — above 21% of stocks peers on PortfoliosLab. Its historical combined result is below the peer median.
Risk / Return Metrics
The table below present risk-adjusted performance metrics for Mereo BioPharma Group plc (MREO) and compare them to S&P 500 Index.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| MREO | Benchmark | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -2.04 | ||
| Sortino ratioReturn per unit of downside risk | -1.95 | ||
| Omega ratioGain probability vs. loss probability | 1.00 | 1.25 | -0.25 |
| Calmar ratioReturn relative to maximum drawdown | -0.89 | 2.00 | -2.89 |
| Martin ratioReturn relative to average drawdown | -1.22 | 8.49 | -9.71 |
Dividends
Dividend History
Drawdowns
Drawdowns Chart
The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.
Loading charts...
Worst Drawdowns
The table below displays the maximum drawdowns of the Mereo BioPharma Group plc. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.
The maximum drawdown for the Mereo BioPharma Group plc was 96.35%, occurring on May 6, 2026. The portfolio has not yet recovered.
The current Mereo BioPharma Group plc drawdown is 94.73%.
Drawdown | Fall | Recovery | Underwater | Related event |
|---|---|---|---|---|
-96.35%May 2026 | 7y 13d | — | 7y 3moApr 2019 - now | — |
Drawdown Indicators
| MREO | Benchmark | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -96.35% | -56.78% | -39.57% |
Max Drawdown (1Y)Largest decline over 1 year | -89.73% | -9.10% | -80.63% |
Max Drawdown (3Y)Largest decline over 3 years | -95.13% | -18.90% | -76.23% |
Max Drawdown (5Y)Largest decline over 5 years | -95.13% | -25.43% | -69.70% |
Max Drawdown (10Y)Largest decline over 10 years | — | -33.92% | — |
Current DrawdownCurrent decline from peak | -94.73% | -1.58% | -93.15% |
Average DrawdownAverage peak-to-trough decline | -66.50% | -10.70% | -55.80% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 65.21% | 2.14% | +63.07% |
Volatility
Volatility Chart
The chart below shows the rolling one-month volatility.
Loading charts...
Financials
Financial Performance
The chart below illustrates the trends in the financial health of Mereo BioPharma Group plc over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.
Valuation
The Valuation section provides an overview of how Mereo BioPharma Group plc is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.
PS Ratio
This chart shows the Price-to-Sales (P/S) ratio for MREO relative to other companies in the Biotechnology industry. Currently, MREO has a P/S ratio of 109.6. This P/S ratio is high relative to other companies in the industry. It could mean the stock is overvalued, or that investors expect strong future growth and profitability.
PB Ratio
The chart illustrates the Price-to-Book (P/B) ratio for MREO in comparison with other companies in the Biotechnology industry. Currently, MREO has a P/B value of 1.6. This P/B ratio is in line with the industry average, suggesting the stock is valued fairly in relation to its book value.
Income Statement
| TTM | |
|---|---|
Revenue | |
Total Revenue | — |
Cost Of Revenue | — |
Gross Profit | — |
Operating Expenses | |
Selling, General & Admin Expenses | — |
R&D Expenses | — |
Depreciation And Amortization | — |
Total Operating Expenses | — |
Income | |
Income Before Tax | — |
Operating Income | — |
EBITDA | — |
EBIT | — |
Earnings From Continuing Operations | — |
Net Income | — |
Income Tax Expense | — |
Other Non-Operating Income (Expenses) | — |
Extraordinary Items | — |
Discontinued Operations | — |
Effect Of Accounting Charges | — |
Non Recurring | — |
Minority Interest | — |
Other Items | — |
Interest Income | — |
Interest Expense | — |
Net Interest Income | — |
Build a portfolio with MREO
Add Mereo BioPharma Group plc to a portfolio and analyze allocations for your target — whether that's maximizing returns, minimizing drawdowns, or balancing risk across holdings.
Open Portfolio Analyzer with MREO