MDGL vs. AXSM
MDGL (Madrigal Pharmaceuticals, Inc.) and AXSM (Axsome Therapeutics, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 10 years, MDGL returned 43.76%/yr vs 40.74%/yr for AXSM. At a 0.27 correlation, their price movements are largely independent.
Performance
MDGL vs. AXSM - Performance Comparison
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Returns By Period
In the year-to-date period, MDGL achieves a -16.17% return, which is significantly lower than AXSM's 27.84% return. Over the past 10 years, MDGL has outperformed AXSM with an annualized return of 43.76%, while AXSM has yielded a comparatively lower 40.74% annualized return.
MDGL
- 1D
- 7.79%
- 1M
- -5.88%
- YTD
- -16.17%
- 6M
- -15.82%
- 1Y
- 71.64%
- 3Y*
- 23.37%
- 5Y*
- 37.02%
- 10Y*
- 43.76%
AXSM
- 1D
- 5.10%
- 1M
- 4.38%
- YTD
- 27.84%
- 6M
- 57.97%
- 1Y
- 112.05%
- 3Y*
- 46.59%
- 5Y*
- 30.66%
- 10Y*
- 40.74%
MDGL vs. AXSM - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
MDGL Madrigal Pharmaceuticals, Inc. | -16.17% | 88.72% | 33.36% | -20.28% | 242.52% | -23.77% | 22.02% | -19.17% | 22.80% | 516.04% |
AXSM Axsome Therapeutics, Inc. | 27.84% | 115.86% | 6.31% | 3.19% | 104.16% | -53.63% | -21.18% | 3,565.25% | -49.64% | -17.04% |
Correlation
The correlation between MDGL and AXSM is 0.34, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.34 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.30 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.33 |
Correlation (10Y) Calculated over the trailing 10-year period | 0.27 |
Correlation (All Time) Calculated using the full available price history since Nov 20, 2015 | 0.27 |
Fundamentals
MDGL:
$14.17B
AXSM:
$11.95B
MDGL:
-$12.87
AXSM:
-$3.74
MDGL:
10.36
AXSM:
16.59
MDGL:
26.08
AXSM:
219.00
MDGL:
$1.13B
AXSM:
$708.24M
MDGL:
$1.05B
AXSM:
$655.82M
MDGL:
-$287.63M
AXSM:
-$172.72M
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Return for Risk
MDGL vs. AXSM — Risk / Return Rank
MDGL
AXSM
MDGL vs. AXSM - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Madrigal Pharmaceuticals, Inc. (MDGL) and Axsome Therapeutics, Inc. (AXSM). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| MDGL | AXSM | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -1.13 | ||
| Sortino ratioReturn per unit of downside risk | -1.61 | ||
| Omega ratioGain probability vs. loss probability | 1.29 | 1.48 | -0.19 |
| Calmar ratioReturn relative to maximum drawdown | 2.45 | 6.09 | -3.64 |
| Martin ratioReturn relative to average drawdown | 5.56 | 17.16 | -11.60 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| MDGL | AXSM | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 1.57 | 2.70 | -1.13 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | 0.28 | 0.44 | -0.16 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | 0.37 | 0.45 | -0.08 |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.02 | 0.40 | -0.38 |
Drawdowns
MDGL vs. AXSM - Drawdown Comparison
The maximum MDGL drawdown since its inception was -98.40%, which is greater than AXSM's maximum drawdown of -86.65%. Use the drawdown chart below to compare losses from any high point for MDGL and AXSM.
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Drawdown Indicators
| MDGL | AXSM | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -98.40% | -86.65% | -11.75% |
Max Drawdown (1Y)Largest decline over 1 year | -29.36% | -18.50% | -10.86% |
Max Drawdown (3Y)Largest decline over 3 years | -56.45% | -36.45% | -20.00% |
Max Drawdown (5Y)Largest decline over 5 years | -61.41% | -72.91% | +11.50% |
Max Drawdown (10Y)Largest decline over 10 years | -82.19% | -81.26% | -0.93% |
Current DrawdownCurrent decline from peak | -19.02% | -1.05% | -17.97% |
Average DrawdownAverage peak-to-trough decline | -58.56% | -39.59% | -18.97% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 12.94% | 6.56% | +6.38% |
Volatility
MDGL vs. AXSM - Volatility Comparison
Madrigal Pharmaceuticals, Inc. (MDGL) has a higher volatility of 16.33% compared to Axsome Therapeutics, Inc. (AXSM) at 9.83%. This indicates that MDGL's price experiences larger fluctuations and is considered to be riskier than AXSM based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| MDGL | AXSM | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 16.33% | 9.83% | +6.50% |
Volatility (6M)Calculated over the trailing 6-month period | 31.56% | 33.54% | -1.98% |
Volatility (1Y)Calculated over the trailing 1-year period | 46.14% | 41.84% | +4.30% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 133.42% | 70.36% | +63.06% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 117.52% | 90.67% | +26.85% |
Dividends
MDGL vs. AXSM - Dividend Comparison
Neither MDGL nor AXSM has paid dividends to shareholders.
Financials
MDGL vs. AXSM - Financials Comparison
This section allows you to compare key financial metrics between Madrigal Pharmaceuticals, Inc. and Axsome Therapeutics, Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
MDGL vs. AXSM - Profitability Comparison
MDGL - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Madrigal Pharmaceuticals, Inc. reported a gross profit of 284.49M and revenue of 311.34M. Therefore, the gross margin over that period was 91.4%.
AXSM - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Axsome Therapeutics, Inc. reported a gross profit of 176.48M and revenue of 191.20M. Therefore, the gross margin over that period was 92.3%.
MDGL - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Madrigal Pharmaceuticals, Inc. reported an operating income of -92.72M and revenue of 311.34M, resulting in an operating margin of -29.8%.
AXSM - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Axsome Therapeutics, Inc. reported an operating income of -63.36M and revenue of 191.20M, resulting in an operating margin of -33.1%.
MDGL - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Madrigal Pharmaceuticals, Inc. reported a net income of -94.39M and revenue of 311.34M, resulting in a net margin of -30.3%.
AXSM - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Axsome Therapeutics, Inc. reported a net income of -64.54M and revenue of 191.20M, resulting in a net margin of -33.8%.
Frequently Asked Questions
MDGL and AXSM have a correlation of 0.34, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
MDGL has higher volatility (16.33%) compared to AXSM (9.83%). In terms of maximum drawdown, MDGL dropped -98.40% vs AXSM's -86.65%.
AXSM currently has the higher Sharpe Ratio (2.70 vs 1.57), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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