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Madrigal Pharmaceuticals, Inc. (MDGL)
Performance
Risk-Adjusted Performance
Dividends
Drawdowns
Volatility
Financials

Company Info

ISIN

US5588681057

CUSIP

558868105

IPO Date

Feb 6, 2007

Highlights

Market Cap

$6.80B

EPS (TTM)

-$17.83

Total Revenue (TTM)

$317.38M

Gross Profit (TTM)

$306.81M

EBITDA (TTM)

-$376.15M

Year Range

$200.63 - $377.46

Target Price

$421.93

Short %

21.04%

Short Ratio

13.64

Share Price Chart


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Performance

Performance Chart

The chart shows the growth of an initial investment of $10,000 in Madrigal Pharmaceuticals, Inc., comparing it to the performance of the S&P 500 index or another benchmark. All prices have been adjusted for splits and dividends.


0.00%100.00%200.00%300.00%December2025FebruaryMarchAprilMay
-7.39%
290.88%
MDGL (Madrigal Pharmaceuticals, Inc.)
Benchmark (^GSPC)

Returns By Period

Madrigal Pharmaceuticals, Inc. (MDGL) returned -4.51% year-to-date (YTD) and 42.39% over the past 12 months. Over the past 10 years, MDGL delivered an annualized return of 13.84%, outperforming the S&P 500 benchmark at 10.45%.


MDGL

YTD

-4.51%

1M

-6.15%

6M

-15.99%

1Y

42.39%

5Y*

26.60%

10Y*

13.84%

^GSPC (Benchmark)

YTD

-3.77%

1M

3.72%

6M

-5.60%

1Y

8.55%

5Y*

14.11%

10Y*

10.45%

*Annualized

Monthly Returns

The table below presents the monthly returns of MDGL, with color gradation from worst to best to easily spot seasonal factors. Returns are adjusted for dividends.


JanFebMarAprMayJunJulAugSepOctNovDecTotal
20258.50%1.93%-2.94%0.81%-11.76%-4.51%
2024-6.34%8.99%13.06%-23.60%15.75%18.63%1.61%-13.18%-14.13%22.20%26.55%-5.98%33.36%
2023-0.69%-5.98%-10.61%28.79%-10.77%-17.03%-11.13%-12.32%-18.87%-10.04%54.74%13.81%-20.28%
2022-32.05%61.25%5.68%-28.66%-5.16%7.82%-12.24%14.80%-9.89%8.97%-1.00%313.99%242.52%
20216.83%2.05%-3.48%16.35%-17.49%-13.26%-10.36%-5.23%-3.58%-2.56%6.38%2.45%-23.77%
2020-8.88%3.79%-22.53%25.34%38.65%-2.39%-9.40%4.96%10.24%7.18%-8.22%-4.81%22.02%
20192.70%13.41%-4.59%-15.31%-12.90%13.43%-16.72%6.20%-6.99%7.20%19.76%-17.69%-19.17%
201861.70%-15.08%-7.34%-3.11%134.72%5.30%-8.10%-6.93%-10.48%-10.87%-39.41%-2.53%22.80%
20172.55%2.09%-1.28%7.14%-7.76%6.83%-4.67%10.19%163.35%11.14%0.70%82.34%516.04%
2016-30.43%-7.10%5.49%66.67%-12.50%-25.66%-17.65%53.87%9.88%30.13%-2.97%-6.93%20.94%
2015-10.19%0.84%-19.17%15.98%-4.89%4.21%-4.93%-5.66%-13.00%-61.49%-36.13%-17.74%-86.72%
20141.91%15.73%-30.26%-2.32%-2.61%-0.24%-3.42%1.27%-24.75%-1.66%7.09%-16.40%-49.43%

Risk-Adjusted Performance

Risk-Adjusted Performance Rank

With an overall rank of 76, MDGL is among the top 24% of stocks on our website when it comes to balancing risk and reward. Below is a breakdown of how it compares using common performance measures.


The Risk-Adjusted Performance Rank of MDGL is 7676
Overall Rank
The Sharpe Ratio Rank of MDGL is 7878
Sharpe Ratio Rank
The Sortino Ratio Rank of MDGL is 7575
Sortino Ratio Rank
The Omega Ratio Rank of MDGL is 7070
Omega Ratio Rank
The Calmar Ratio Rank of MDGL is 7878
Calmar Ratio Rank
The Martin Ratio Rank of MDGL is 7777
Martin Ratio Rank
The risk-adjusted ranks indicate the investment's position relative to the market. A rank closer to 100 signifies top-performing investments, while a rank closer to 0 might suggest underperformance, based on the selected ratio. The values are calculated based on the past 12 months of returns.

Risk-Adjusted Performance Indicators

The charts below present risk-adjusted performance metrics for Madrigal Pharmaceuticals, Inc. (MDGL) and compare them to a chosen benchmark (^GSPC). These indicators evaluate an investment's returns against its associated risks.


The Sharpe ratio helps investors understand how much return they're getting for the level of risk taken. A higher Sharpe ratio indicates better risk-adjusted performance, meaning more reward for each unit of risk.

Madrigal Pharmaceuticals, Inc. Sharpe ratios as of May 10, 2025 (values are recalculated daily):

  • 1-Year: 0.71
  • 5-Year: 0.20
  • 10-Year: 0.11
  • All Time: -0.00

These values reflect how efficiently the investment has delivered returns relative to its volatility over different time periods. All figures are annualized and based on daily total returns (including price changes and dividends).

The chart below shows the rolling Sharpe ratio of Madrigal Pharmaceuticals, Inc. compared to the selected benchmark. This view highlights how the investment's risk-adjusted performance has changed over time. For deeper analysis or to customize the calculation, use the Sharpe ratio tool.


Rolling 12-month Sharpe Ratio0.001.002.003.00December2025FebruaryMarchAprilMay
0.71
0.44
MDGL (Madrigal Pharmaceuticals, Inc.)
Benchmark (^GSPC)

Dividends

Dividend History


Madrigal Pharmaceuticals, Inc. doesn't pay dividends

Drawdowns

Drawdowns Chart

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.


-35.00%-30.00%-25.00%-20.00%-15.00%-10.00%-5.00%0.00%December2025FebruaryMarchAprilMay
-28.11%
-7.88%
MDGL (Madrigal Pharmaceuticals, Inc.)
Benchmark (^GSPC)

Worst Drawdowns

The table below displays the maximum drawdowns of the Madrigal Pharmaceuticals, Inc.. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the Madrigal Pharmaceuticals, Inc. was 98.40%, occurring on Feb 11, 2016. The portfolio has not yet recovered.

The current Madrigal Pharmaceuticals, Inc. drawdown is 28.11%.


Depth

Start

To Bottom

Bottom

To Recover

End

Total

-98.4%Jan 29, 2013766Feb 11, 2016
-87.64%Oct 8, 2007351Feb 27, 2009981Jan 22, 20131332
-51.43%Jun 5, 200758Aug 24, 200728Oct 4, 200786
-18.88%Feb 12, 200740Apr 10, 200738Jun 4, 200778
-4.32%Jan 24, 20131Jan 24, 20131Jan 25, 20132

Volatility

Volatility Chart

The current Madrigal Pharmaceuticals, Inc. volatility is 11.63%, representing the average percentage change in the investments's value, either up or down over the past month. The chart below shows the rolling one-month volatility.


0.00%5.00%10.00%15.00%20.00%25.00%30.00%35.00%December2025FebruaryMarchAprilMay
11.63%
6.82%
MDGL (Madrigal Pharmaceuticals, Inc.)
Benchmark (^GSPC)

Financials

Financial Performance

The chart below illustrates the trends in the financial health of Madrigal Pharmaceuticals, Inc. over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.


Annual
Quarterly

0.0

Earnings Per Share

The chart presents the Earnings Per Share (EPS) performance of Madrigal Pharmaceuticals, Inc., comparing actual results with analytics estimates. The company has exceeded analyst expectations for EPS in the past quarter, achieving a 47.1% positive surprise.


-8.00-7.00-6.00-5.00-4.00-3.00-2.0020212022202320242025
-3.32
-6.28
Actual
Estimate

Valuation

The Valuation section provides an overview of how Madrigal Pharmaceuticals, Inc. is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.


PEG Ratio

The chart shows the Price/Earnings to Growth (PEG) ratio for MDGL compared to other companies in the Biotechnology industry. MDGL currently has a PEG ratio of 0.0. This PEG ratio is low compared to industry peers, which could indicate the stock is undervalued relative to its expected growth.

PS Ratio

This chart shows the Price-to-Sales (P/S) ratio for MDGL relative to other companies in the Biotechnology industry. Currently, MDGL has a P/S ratio of 40.4. This P/S ratio falls within the average range for the industry, suggesting the stock is fairly valued based on its revenue.

PB Ratio

The chart illustrates the Price-to-Book (P/B) ratio for MDGL in comparison with other companies in the Biotechnology industry. Currently, MDGL has a P/B value of 10.2. This P/B ratio is higher than most companies in the industry. It may suggest the stock is overvalued or that investors expect the company to generate high returns on its assets.

Income Statement



TTM
Revenue

Total Revenue

Cost Of Revenue

Gross Profit

Operating Expenses

Selling, General & Admin Expenses

R&D Expenses

Depreciation And Amortization

Total Operating Expenses

Income

Income Before Tax

Operating Income

EBITDA

EBIT

Earnings From Continuing Operations

Net Income

Income Tax Expense

Other Non-Operating Income (Expenses)

Extraordinary Items

Discontinued Operations

Effect Of Accounting Charges

Non Recurring

Minority Interest

Other Items

Interest Income

Interest Expense

Net Interest Income

Values in undefined except per share items