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ISIN
US5588681057
CUSIP
558868105
IPO Date
Feb 6, 2007

Highlights

Market Cap
$14.89B
Enterprise Value
$14.67B
EPS (TTM)
-$12.87
Total Revenue (TTM)
$1.13B
Gross Profit (TTM)
$1.05B
EBITDA (TTM)
-$287.63M
Year Range
$277.64 - $615.00
Target Price
$728.00
ROA (TTM)
-25.21%
ROE (TTM)
-56.94%

Share Price Chart


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Performance

MDGL Performance Chart

Madrigal Pharmaceuticals, Inc. (MDGL) is down 11.9% since the beginning of the year. At $513 per share, MDGL is trading 16.6% below its 52-week high of $615. Investors who bought $1,000 worth of MDGL shares 5 years ago would now be looking at an investment worth $5,076.


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S&P 500 Index

Returns By Period

Madrigal Pharmaceuticals, Inc. (MDGL) has returned -11.93% so far this year and 79.50% over the past 12 months. Looking at the last ten years, MDGL has achieved an annualized return of 47.15%, outperforming the S&P 500 Index benchmark, which averaged 13.88% per year.


Madrigal Pharmaceuticals, Inc.

1D
1.41%
1M
-0.85%
YTD
-11.93%
6M
-14.92%
1Y
79.50%
3Y*
29.23%
5Y*
38.39%
10Y*
47.15%

Benchmark (S&P 500 Index)

1D
-0.37%
1M
-0.01%
YTD
9.16%
6M
8.64%
1Y
25.22%
3Y*
19.78%
5Y*
11.99%
10Y*
13.88%
*Multi-year figures are annualized to reflect compound growth (CAGR)

MDGL Monthly Returns History

Based on dividend-adjusted daily data since Feb 6, 2007, MDGL's average daily return is +0.17%, while the average monthly return is +3.72%. At this rate, an investment would double in approximately 1.6 years.

Historically, 47% of months were positive and 53% were negative. The best month was Dec 2022 with a return of +314.0%, while the worst month was Feb 2009 at -84.6%. The longest winning streak lasted 6 consecutive months, and the longest losing streak was 8 months.

On a daily basis, MDGL closed higher 48% of trading days. The best single day was Dec 19, 2022 with a return of +268.1%, while the worst single day was Feb 27, 2009 at -78.7%.


JanFebMarAprMayJunJulAugSepOctNovDecTotal
2026-15.98%-11.71%21.17%-1.16%-3.89%3.14%-11.93%
20258.50%1.93%-2.94%0.81%-17.56%9.95%-0.04%44.74%4.75%-8.67%42.51%-2.45%88.72%
2024-6.34%8.99%13.06%-23.60%15.75%18.63%1.61%-13.18%-14.13%22.20%26.55%-5.98%33.36%
2023-0.69%-5.98%-10.61%28.79%-10.77%-17.03%-11.13%-12.32%-18.87%-10.04%54.74%13.81%-20.28%
2022-32.05%61.25%5.68%-28.66%-5.16%7.82%-12.24%14.80%-9.89%8.97%-1.00%313.99%242.52%
20216.83%2.05%-3.48%16.35%-17.49%-13.26%-10.36%-5.23%-3.58%-2.56%6.38%2.45%-23.77%

Benchmark Metrics

Madrigal Pharmaceuticals, Inc. has an annualized alpha of 39.07%, beta of 1.02, and R2 of 0.04 versus S&P 500 Index. Calculated based on daily prices since February 06, 2007.

  • This stock participated in 126.28% of S&P 500 Index downside but only 98.84% of its upside - more exposed to losses than it benefited from rallies.
  • R2 of 0.04 means this stock moves largely independently of S&P 500 Index - capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.

Alpha
39.07%
Beta
1.02
0.04
Upside Capture
98.84%
Downside Capture
126.28%

Return for Risk

Risk / Return Rank

MDGL ranks 83 for risk / return — in the top 83% of stocks on our site. This means strong returns relative to risk — exactly what professional investors look for. Well-suited for investors who want to maximize return per unit of risk.


MDGL Risk / Return Rank: 8383
Overall Rank
MDGL Sharpe Ratio Rank: 8585
Sharpe Ratio Rank
MDGL Sortino Ratio Rank: 8585
Sortino Ratio Rank
MDGL Omega Ratio Rank: 8282
Omega Ratio Rank
MDGL Calmar Ratio Rank: 8282
Calmar Ratio Rank
MDGL Martin Ratio Rank: 7979
Martin Ratio Rank
The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

Return / Risk — by metrics

The table below present risk-adjusted performance metrics for Madrigal Pharmaceuticals, Inc. (MDGL) and compare them to S&P 500 Index.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.


MDGLBenchmarkDifference
Sharpe ratioReturn per unit of total volatility

-0.29

Sortino ratioReturn per unit of downside risk

-0.14

Omega ratioGain probability vs. loss probability

1.32

1.37

-0.05

Calmar ratioReturn relative to maximum drawdown

2.72

2.78

-0.06

Martin ratioReturn relative to average drawdown

5.88

12.44

-6.56

Dividends

Dividend History


Madrigal Pharmaceuticals, Inc. doesn't pay dividends

Drawdowns

Drawdowns Chart

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.


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Worst Drawdowns

The table below displays the maximum drawdowns of the Madrigal Pharmaceuticals, Inc.. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the Madrigal Pharmaceuticals, Inc. was 98.40%, occurring on Feb 11, 2016. Recovery took 2396 trading sessions.

The current Madrigal Pharmaceuticals, Inc. drawdown is 14.92%.


Related event

Drawdown

Fall

Recovery

Underwater

2016 bear market2016
-98.40%Feb 2016
3y 13d9y 6mo
12y 6moJan 2013 - Aug 2025
Financial crisis2007–2009
-87.64%Feb 2009
1y 4mo3y 11mo
5y 3moOct 2007 - Jan 2013
2007 bear market2007
-51.43%Aug 2007
2mo 20d1mo 11d
4mo 1dJun 2007 - Oct 2007
2026 bear market2026
-29.36%Mar 2026
2mo 10d
6mo 2dDec 2025 - now
2007 bear market2007
-20.10%Apr 2007
2mo 3d1mo 25d
3mo 28dFeb 2007 - Jun 2007

Drawdown Indicators


MDGLBenchmarkDifference

Max Drawdown

Largest peak-to-trough decline

-98.40%

-56.78%

-41.62%

Max Drawdown (1Y)

Largest decline over 1 year

-29.36%

-9.10%

-20.26%

Max Drawdown (3Y)

Largest decline over 3 years

-49.34%

-18.90%

-30.44%

Max Drawdown (5Y)

Largest decline over 5 years

-61.41%

-25.43%

-35.98%

Max Drawdown (10Y)

Largest decline over 10 years

-82.19%

-33.92%

-48.27%

Current Drawdown

Current decline from peak

-14.92%

-1.80%

-13.12%

Average Drawdown

Average peak-to-trough decline

-58.48%

-10.71%

-47.77%

Ulcer Index

Depth and duration of drawdowns from previous peaks

13.56%

2.03%

+11.53%

Volatility

Volatility Chart

The chart below shows the rolling one-month volatility.


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Financials

Financial Performance

The chart below illustrates the trends in the financial health of Madrigal Pharmaceuticals, Inc. over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.


Annual
Quarterly

0.0

Valuation

The Valuation section provides an overview of how Madrigal Pharmaceuticals, Inc. is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.


PS Ratio

This chart shows the Price-to-Sales (P/S) ratio for MDGL relative to other companies in the Biotechnology industry. Currently, MDGL has a P/S ratio of 10.9. This P/S ratio falls within the average range for the industry, suggesting the stock is fairly valued based on its revenue.

PB Ratio

The chart illustrates the Price-to-Book (P/B) ratio for MDGL in comparison with other companies in the Biotechnology industry. Currently, MDGL has a P/B value of 27.4. This P/B ratio is higher than most companies in the industry. It may suggest the stock is overvalued or that investors expect the company to generate high returns on its assets.

Income Statement



TTM
Revenue

Total Revenue

Cost Of Revenue

Gross Profit

Operating Expenses

Selling, General & Admin Expenses

R&D Expenses

Depreciation And Amortization

Total Operating Expenses

Income

Income Before Tax

Operating Income

EBITDA

EBIT

Earnings From Continuing Operations

Net Income

Income Tax Expense

Other Non-Operating Income (Expenses)

Extraordinary Items

Discontinued Operations

Effect Of Accounting Charges

Non Recurring

Minority Interest

Other Items

Interest Income

Interest Expense

Net Interest Income

Values in undefined except per share items
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