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Madrigal Pharmaceuticals, Inc. (MDGL)
Performance
Return for Risk
Dividends
Drawdowns
Volatility
Financials

Company Info

ISIN
US5588681057
CUSIP
558868105
IPO Date
Feb 6, 2007

Highlights

Market Cap
$11.74B
Enterprise Value
$11.55B
EPS (TTM)
-$12.88
Total Revenue (TTM)
$958.40M
Gross Profit (TTM)
$902.26M
EBITDA (TTM)
-$300.10M
Year Range
$265.00 - $615.00
Target Price
$705.67
ROA (TTM)
-22.89%
ROE (TTM)
-47.83%

Share Price Chart


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Performance

Performance Chart

The chart shows the growth of an initial investment of $10,000 in Madrigal Pharmaceuticals, Inc., comparing it to the performance of the S&P 500 index or another benchmark. All prices have been adjusted for splits and dividends.


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S&P 500 Index

Returns By Period

Madrigal Pharmaceuticals, Inc. (MDGL) has returned -10.11% so far this year and 58.04% over the past 12 months. Looking at the last ten years, MDGL has achieved an annualized return of 50.55%, outperforming the S&P 500 Index benchmark, which averaged 12.16% per year.


Madrigal Pharmaceuticals, Inc.

1D
3.59%
1M
21.17%
YTD
-10.11%
6M
14.13%
1Y
58.04%
3Y*
29.28%
5Y*
34.58%
10Y*
50.55%

Benchmark (S&P 500 Index)

1D
2.91%
1M
-5.09%
YTD
-4.63%
6M
-2.39%
1Y
16.33%
3Y*
16.69%
5Y*
10.18%
10Y*
12.16%
*Multi-year figures are annualized to reflect compound growth (CAGR)

Monthly Returns

Based on dividend-adjusted daily data since Feb 6, 2007, MDGL's average daily return is +0.18%, while the average monthly return is +3.81%. At this rate, your investment would double in approximately 1.5 years.

Historically, 47% of months were positive and 53% were negative. The best month was Dec 2022 with a return of +314.0%, while the worst month was Feb 2009 at -84.6%. The longest winning streak lasted 6 consecutive months, and the longest losing streak was 8 months.

On a daily basis, MDGL closed higher 48% of trading days. The best single day was Dec 19, 2022 with a return of +268.1%, while the worst single day was Feb 27, 2009 at -78.7%.


JanFebMarAprMayJunJulAugSepOctNovDecTotal
2026-15.98%-11.71%21.17%-10.11%
20258.50%1.93%-2.94%0.81%-17.56%9.95%-0.04%44.74%4.75%-8.67%42.51%-2.45%88.72%
2024-6.34%8.99%13.06%-23.60%15.75%18.63%1.61%-13.18%-14.13%22.20%26.55%-5.98%33.36%
2023-0.69%-5.98%-10.61%28.79%-10.77%-17.03%-11.13%-12.32%-18.87%-10.04%54.74%13.81%-20.28%
2022-32.05%61.25%5.68%-28.66%-5.16%7.82%-12.24%14.80%-9.89%8.97%-1.00%313.99%242.52%
20216.83%2.05%-3.48%16.35%-17.49%-13.26%-10.36%-5.23%-3.58%-2.56%6.38%2.45%-23.77%

Benchmark Metrics

Madrigal Pharmaceuticals, Inc. has an annualized alpha of 41.30%, beta of 1.03, and R² of 0.04 versus S&P 500 Index. Calculated based on daily prices since February 07, 2007.

  • This stock participated in 125.30% of S&P 500 Index downside but only 103.88% of its upside — more exposed to losses than it benefited from rallies.
  • R² of 0.04 means this stock moves largely independently of S&P 500 Index — capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.

Alpha
41.30%
Beta
1.03
0.04
Upside Capture
103.88%
Downside Capture
125.30%

Return for Risk

Risk / Return Rank

MDGL ranks 77 for risk / return — better than 77% of stocks on our site. You're getting solid returns for the risk taken. A good sign, especially for investors who want growth without excessive volatility.


MDGL Risk / Return Rank: 7777
Overall Rank
MDGL Sharpe Ratio Rank: 8080
Sharpe Ratio Rank
MDGL Sortino Ratio Rank: 7979
Sortino Ratio Rank
MDGL Omega Ratio Rank: 7373
Omega Ratio Rank
MDGL Calmar Ratio Rank: 7777
Calmar Ratio Rank
MDGL Martin Ratio Rank: 7474
Martin Ratio Rank
The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

Return / Risk — by metrics

The table below present risk-adjusted performance metrics for Madrigal Pharmaceuticals, Inc. (MDGL) and compare them to a chosen benchmark (S&P 500 Index).


MDGLBenchmarkDifference

Sharpe ratio

Return per unit of total volatility

1.28

0.90

+0.38

Sortino ratio

Return per unit of downside risk

2.09

1.39

+0.71

Omega ratio

Gain probability vs. loss probability

1.24

1.21

+0.03

Calmar ratio

Return relative to maximum drawdown

2.03

1.40

+0.63

Martin ratio

Return relative to average drawdown

4.45

6.61

-2.16

Explore MDGL risk-adjusted metrics in detail

Dive deeper into individual metrics with historical trends, benchmark comparisons, and performance across different time periods.

Dividends

Dividend History


Madrigal Pharmaceuticals, Inc. doesn't pay dividends

Drawdowns

Drawdowns Chart

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.


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Worst Drawdowns

The table below displays the maximum drawdowns of the Madrigal Pharmaceuticals, Inc.. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the Madrigal Pharmaceuticals, Inc. was 98.40%, occurring on Feb 11, 2016. Recovery took 2396 trading sessions.

The current Madrigal Pharmaceuticals, Inc. drawdown is 13.16%.


Depth

Start

To Bottom

Bottom

To Recover

End

Total

-98.4%Jan 29, 2013766Feb 11, 20162396Aug 22, 20253162
-87.64%Oct 8, 2007351Feb 27, 2009981Jan 22, 20131332
-51.43%Jun 5, 200758Aug 24, 200728Oct 4, 200786
-29.36%Dec 23, 202547Mar 3, 2026
-18.88%Feb 12, 200740Apr 10, 200738Jun 4, 200778

Volatility

Volatility Chart

The chart below shows the rolling one-month volatility.


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Financials

Financial Performance

The chart below illustrates the trends in the financial health of Madrigal Pharmaceuticals, Inc. over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.


Annual
Quarterly

0.0

Valuation

The Valuation section provides an overview of how Madrigal Pharmaceuticals, Inc. is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.


PS Ratio

This chart shows the Price-to-Sales (P/S) ratio for MDGL relative to other companies in the Biotechnology industry. Currently, MDGL has a P/S ratio of 12.2. This P/S ratio falls within the average range for the industry, suggesting the stock is fairly valued based on its revenue.

PB Ratio

The chart illustrates the Price-to-Book (P/B) ratio for MDGL in comparison with other companies in the Biotechnology industry. Currently, MDGL has a P/B value of 19.5. This P/B ratio is higher than most companies in the industry. It may suggest the stock is overvalued or that investors expect the company to generate high returns on its assets.

Income Statement



TTM
Revenue

Total Revenue

Cost Of Revenue

Gross Profit

Operating Expenses

Selling, General & Admin Expenses

R&D Expenses

Depreciation And Amortization

Total Operating Expenses

Income

Income Before Tax

Operating Income

EBITDA

EBIT

Earnings From Continuing Operations

Net Income

Income Tax Expense

Other Non-Operating Income (Expenses)

Extraordinary Items

Discontinued Operations

Effect Of Accounting Charges

Non Recurring

Minority Interest

Other Items

Interest Income

Interest Expense

Net Interest Income

Values in undefined except per share items