MDGL vs. VOO

Last updated Jun 24, 2026

MDGL (Madrigal Pharmaceuticals, Inc.) is a stock, while VOO (Vanguard S&P 500 ETF) is S&P 500 fund tracking the S&P 500 Index. Over the past 10 years, MDGL returned 47.16%/yr vs 15.61%/yr for VOO. At a 0.34 correlation, their price movements are largely independent.

Performance

MDGL vs. VOO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Madrigal Pharmaceuticals, Inc. (MDGL) and Vanguard S&P 500 ETF (VOO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, MDGL achieves a -11.83% return, which is significantly lower than VOO's 8.19% return. Over the past 10 years, MDGL has outperformed VOO with an annualized return of 47.16%, while VOO has yielded a comparatively lower 15.61% annualized return.

MDGL

• 1D: 0.11%
• 1M: -0.74%
• YTD: -11.83%
• 6M: -14.74%
• 1Y: 81.43%
• 3Y*: 29.27%
• 5Y*: 38.39%
• 10Y*: 47.16%

VOO

• 1D: -1.42%
• 1M: -1.34%
• YTD: 8.19%
• 6M: 7.24%
• 1Y: 23.69%
• 3Y*: 20.78%
• 5Y*: 13.13%
• 10Y*: 15.61%

*Multi-year figures are annualized to reflect compound growth (CAGR)

MDGL vs. VOO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
MDGL Madrigal Pharmaceuticals, Inc.	-11.83%	88.72%	33.36%	-20.28%	242.52%	-23.77%	22.02%	-19.17%	22.80%	516.04%
VOO Vanguard S&P 500 ETF	8.19%	17.82%	24.98%	26.32%	-18.17%	28.79%	18.32%	31.37%	-4.50%	21.77%

Correlation

The correlation between MDGL and VOO is 0.22, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.22
Correlation (3Y) Calculated over the trailing 3-year period	0.29
Correlation (5Y) Calculated over the trailing 5-year period	0.31
Correlation (10Y) Calculated over the trailing 10-year period	0.32
Correlation (All Time) Calculated using the full available price history since Sep 9, 2010	0.34

The correlation between MDGL and VOO shifts across timeframes, from 0.22 (1 year) to 0.34 (all time), reflecting how their relationship changes across market environments.

Return for Risk

MDGL vs. VOO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

MDGL

MDGL Risk / Return Rank: 83
MDGL Sharpe Ratio Rank: 86
MDGL Sortino Ratio Rank: 86
MDGL Omega Ratio Rank: 83
MDGL Calmar Ratio Rank: 82
MDGL Martin Ratio Rank: 79

VOO

VOO Risk / Return Rank: 59
VOO Sharpe Ratio Rank: 59
VOO Sortino Ratio Rank: 56
VOO Omega Ratio Rank: 58
VOO Calmar Ratio Rank: 56
VOO Martin Ratio Rank: 67

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

MDGL vs. VOO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Madrigal Pharmaceuticals, Inc. (MDGL) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	MDGL	VOO	Difference
Sharpe ratio: Return per unit of total volatility	1.78	1.91	-0.13
Sortino ratio: Return per unit of downside risk	2.66	2.60	+0.06
Omega ratio: Gain probability vs. loss probability	1.32	1.35	-0.03
Calmar ratio: Return relative to maximum drawdown	2.79	2.67	+0.12
Martin ratio: Return relative to average drawdown	6.01	11.96	-5.95

MDGL vs. VOO - Sharpe Ratio Comparison

The current MDGL Sharpe Ratio is 1.78, which is comparable to the VOO Sharpe Ratio of 1.91. The chart below compares the historical Sharpe Ratios of MDGL and VOO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

MDGL vs. VOO - Drawdown Comparison

The maximum MDGL drawdown since its inception was -98.40%, which is greater than VOO's maximum drawdown of -33.99%. Use the drawdown chart below to compare losses from any high point for MDGL and VOO.

Drawdown Indicators

	MDGL	VOO	Difference
Max Drawdown Largest peak-to-trough decline	-98.40%	-33.99%	-64.41%
Max Drawdown (1Y) Largest decline over 1 year	-29.36%	-8.90%	-20.46%
Max Drawdown (3Y) Largest decline over 3 years	-49.34%	-18.69%	-30.65%
Max Drawdown (5Y) Largest decline over 5 years	-61.41%	-24.52%	-36.89%
Max Drawdown (10Y) Largest decline over 10 years	-82.19%	-33.99%	-48.20%
Current Drawdown Current decline from peak	-14.83%	-3.14%	-11.69%
Average Drawdown Average peak-to-trough decline	-58.47%	-3.68%	-54.79%
Ulcer Index Depth and duration of drawdowns from previous peaks	13.59%	1.99%	+11.60%

Volatility

MDGL vs. VOO - Volatility Comparison

Madrigal Pharmaceuticals, Inc. (MDGL) has a higher volatility of 13.40% compared to Vanguard S&P 500 ETF (VOO) at 4.83%. This indicates that MDGL's price experiences larger fluctuations and is considered to be riskier than VOO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	MDGL	VOO	Difference
Volatility (1M) Calculated over the trailing 1-month period	13.40%	4.83%	+8.57%
Volatility (6M) Calculated over the trailing 6-month period	31.78%	9.82%	+21.96%
Volatility (1Y) Calculated over the trailing 1-year period	45.91%	12.46%	+33.45%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	133.47%	16.91%	+116.56%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	117.50%	18.02%	+99.48%

Dividends

MDGL vs. VOO - Dividend Comparison

MDGL has not paid dividends to shareholders, while VOO's dividend yield for the trailing twelve months is around 1.05%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
MDGL Madrigal Pharmaceuticals, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
VOO Vanguard S&P 500 ETF	1.05%	1.13%	1.24%	1.46%	1.69%	1.25%	1.54%	1.88%	2.06%	1.78%	2.02%	2.10%

Frequently Asked Questions

Can I hold both MDGL and VOO in my portfolio?

MDGL and VOO have a correlation of 0.22, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, MDGL or VOO?

MDGL has higher volatility (13.40%) compared to VOO (4.83%). In terms of maximum drawdown, MDGL dropped -98.40% vs VOO's -33.99%.

Which has better risk-adjusted returns?

VOO currently has the higher Sharpe Ratio (1.91 vs 1.78), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.