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Axsome Therapeutics, Inc. (AXSM)
Performance
Return for Risk
Dividends
Drawdowns
Volatility
Financials

Company Info

ISIN
US05464T1043
CUSIP
05464T104
IPO Date
Nov 19, 2015

Highlights

Market Cap
$8.56B
Enterprise Value
$8.52B
EPS (TTM)
-$3.66
Total Revenue (TTM)
$638.50M
Gross Profit (TTM)
$591.02M
EBITDA (TTM)
-$168.76M
Year Range
$86.99 - $191.50
Target Price
$220.07
ROA (TTM)
-26.55%
ROE (TTM)
-207.46%

Share Price Chart


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Performance

Performance Chart

The chart shows the growth of an initial investment of $10,000 in Axsome Therapeutics, Inc., comparing it to the performance of the S&P 500 index or another benchmark. All prices have been adjusted for splits and dividends.


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S&P 500 Index

Returns By Period

Axsome Therapeutics, Inc. (AXSM) has returned -7.46% so far this year and 44.92% over the past 12 months. Looking at the last ten years, AXSM has achieved an annualized return of 34.16%, outperforming the S&P 500 Index benchmark, which averaged 12.16% per year.


Axsome Therapeutics, Inc.

1D
5.31%
1M
3.13%
YTD
-7.46%
6M
39.17%
1Y
44.92%
3Y*
39.94%
5Y*
24.07%
10Y*
34.16%

Benchmark (S&P 500 Index)

1D
2.91%
1M
-5.09%
YTD
-4.63%
6M
-2.39%
1Y
16.33%
3Y*
16.69%
5Y*
10.18%
10Y*
12.16%
*Multi-year figures are annualized to reflect compound growth (CAGR)

Monthly Returns

Based on dividend-adjusted daily data since Nov 19, 2015, AXSM's average daily return is +0.26%, while the average monthly return is +5.64%. At this rate, your investment would double in approximately 1.1 years.

Historically, 51% of months were positive and 49% were negative. The best month was Jan 2019 with a return of +197.5%, while the worst month was Jan 2018 at -50.0%. The longest winning streak lasted 6 consecutive months, and the longest losing streak was 5 months.

On a daily basis, AXSM closed higher 48% of trading days. The best single day was Jan 7, 2019 with a return of +161.2%, while the worst single day was Aug 9, 2021 at -46.5%.


JanFebMarAprMayJunJulAugSepOctNovDecTotal
20260.88%-11.05%3.13%-7.46%
202525.82%19.80%-8.55%-3.72%-6.35%-0.73%-2.88%19.63%0.14%11.15%12.23%20.55%115.86%
202413.12%-9.61%-1.94%-7.57%-0.45%9.63%8.46%1.78%1.14%-0.93%10.32%-13.86%6.31%
2023-2.76%-9.08%-9.55%15.97%3.15%-2.60%9.20%2.97%-13.50%-10.89%8.30%18.00%3.19%
2022-27.37%2.44%47.24%-23.29%-21.26%53.20%0.76%65.33%-30.06%1.19%60.11%6.70%104.16%
2021-16.42%-1.07%-15.94%6.78%0.41%11.12%-27.97%-47.15%28.35%16.81%-10.29%9.38%-53.63%

Benchmark Metrics

Axsome Therapeutics, Inc. has an annualized alpha of 68.79%, beta of 0.97, and R² of 0.04 versus S&P 500 Index. Calculated based on daily prices since November 20, 2015.

  • This stock captured 180.24% of S&P 500 Index gains but only 89.02% of its losses — a favorable profile for investors.
  • R² of 0.04 means this stock moves largely independently of S&P 500 Index — capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.

Alpha
68.79%
Beta
0.97
0.04
Upside Capture
180.24%
Downside Capture
89.02%

Return for Risk

Risk / Return Rank

AXSM ranks 76 for risk / return — better than 76% of stocks on our site. You're getting solid returns for the risk taken. A good sign, especially for investors who want growth without excessive volatility.


AXSM Risk / Return Rank: 7676
Overall Rank
AXSM Sharpe Ratio Rank: 7676
Sharpe Ratio Rank
AXSM Sortino Ratio Rank: 7575
Sortino Ratio Rank
AXSM Omega Ratio Rank: 7272
Omega Ratio Rank
AXSM Calmar Ratio Rank: 8080
Calmar Ratio Rank
AXSM Martin Ratio Rank: 7777
Martin Ratio Rank
The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

Return / Risk — by metrics

The table below present risk-adjusted performance metrics for Axsome Therapeutics, Inc. (AXSM) and compare them to a chosen benchmark (S&P 500 Index).


AXSMBenchmarkDifference

Sharpe ratio

Return per unit of total volatility

1.11

0.90

+0.21

Sortino ratio

Return per unit of downside risk

1.90

1.39

+0.52

Omega ratio

Gain probability vs. loss probability

1.23

1.21

+0.02

Calmar ratio

Return relative to maximum drawdown

2.30

1.40

+0.90

Martin ratio

Return relative to average drawdown

5.19

6.61

-1.42

Explore AXSM risk-adjusted metrics in detail

Dive deeper into individual metrics with historical trends, benchmark comparisons, and performance across different time periods.

Dividends

Dividend History


Axsome Therapeutics, Inc. doesn't pay dividends

Drawdowns

Drawdowns Chart

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.


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Worst Drawdowns

The table below displays the maximum drawdowns of the Axsome Therapeutics, Inc.. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the Axsome Therapeutics, Inc. was 86.65%, occurring on Dec 27, 2018. Recovery took 59 trading sessions.

The current Axsome Therapeutics, Inc. drawdown is 10.62%.


Depth

Start

To Bottom

Bottom

To Recover

End

Total

-86.65%Jan 6, 2016750Dec 27, 201859Mar 25, 2019809
-81.26%Dec 27, 2019415Aug 19, 2021865Jan 30, 20251280
-42.7%Sep 17, 201911Oct 1, 201935Nov 19, 201946
-30.56%Feb 24, 202534Apr 10, 2025145Nov 6, 2025179
-18.5%Jan 22, 202635Mar 12, 2026

Volatility

Volatility Chart

The chart below shows the rolling one-month volatility.


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Financials

Financial Performance

The chart below illustrates the trends in the financial health of Axsome Therapeutics, Inc. over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.


Annual
Quarterly

0.0

Valuation

The Valuation section provides an overview of how Axsome Therapeutics, Inc. is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.


PS Ratio

This chart shows the Price-to-Sales (P/S) ratio for AXSM relative to other companies in the Biotechnology industry. Currently, AXSM has a P/S ratio of 13.2. This P/S ratio falls within the average range for the industry, suggesting the stock is fairly valued based on its revenue.

PB Ratio

The chart illustrates the Price-to-Book (P/B) ratio for AXSM in comparison with other companies in the Biotechnology industry. Currently, AXSM has a P/B value of 96.9. This P/B ratio is higher than most companies in the industry. It may suggest the stock is overvalued or that investors expect the company to generate high returns on its assets.

Income Statement



TTM
Revenue

Total Revenue

Cost Of Revenue

Gross Profit

Operating Expenses

Selling, General & Admin Expenses

R&D Expenses

Depreciation And Amortization

Total Operating Expenses

Income

Income Before Tax

Operating Income

EBITDA

EBIT

Earnings From Continuing Operations

Net Income

Income Tax Expense

Other Non-Operating Income (Expenses)

Extraordinary Items

Discontinued Operations

Effect Of Accounting Charges

Non Recurring

Minority Interest

Other Items

Interest Income

Interest Expense

Net Interest Income

Values in undefined except per share items