MDEV vs. SBIO

Last updated Jun 4, 2026

MDEV (First Trust Indxx Medical Devices ETF) and SBIO (ALPS Medical Breakthroughs ETF) are both Health & Biotech Equities funds - MDEV tracks the Indxx Global Medical Equipment Index while SBIO tracks the S-Network Medical Breakthroughs Index. Both are passively managed. Over the past 3 years, MDEV returned -2.86%/yr vs 17.80%/yr for SBIO. A 0.54 correlation means they provide meaningful diversification when combined. MDEV charges 0.70%/yr vs 0.50%/yr for SBIO.

Performance

MDEV vs. SBIO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in First Trust Indxx Medical Devices ETF (MDEV) and ALPS Medical Breakthroughs ETF (SBIO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, MDEV achieves a -11.48% return, which is significantly lower than SBIO's -0.39% return.

MDEV

• 1D: 0.04%
• 1M: 1.54%
• YTD: -11.48%
• 6M: -12.29%
• 1Y: -7.05%
• 3Y*: -2.86%
• 5Y*: —
• 10Y*: —

SBIO

• 1D: 1.41%
• 1M: -7.56%
• YTD: -0.39%
• 6M: 3.05%
• 1Y: 65.41%
• 3Y*: 17.80%
• 5Y*: 2.68%
• 10Y*: 8.02%

*Multi-year figures are annualized to reflect compound growth (CAGR)

MDEV vs. SBIO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
MDEV First Trust Indxx Medical Devices ETF	-11.48%	2.00%	1.79%	7.55%	-28.59%	4.16%
SBIO ALPS Medical Breakthroughs ETF	-0.39%	55.07%	3.81%	8.68%	-28.08%	-13.48%

Correlation

The correlation between MDEV and SBIO is 0.41, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.41
Correlation (3Y) Calculated over the trailing 3-year period	0.47
Correlation (All Time) Calculated using the full available price history since Jun 24, 2021	0.54

The correlation between MDEV and SBIO shifts across timeframes, from 0.41 (1 year) to 0.54 (all time), reflecting how their relationship changes across market environments.

MDEV vs. SBIO - Sectors Allocation Comparison

Sectors	MDEV	SBIO
Healthcare	100.0%	100.0%
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	-0.0%
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

MDEV vs. SBIO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

MDEV

MDEV Risk / Return Rank: 5
MDEV Sharpe Ratio Rank: 5
MDEV Sortino Ratio Rank: 5
MDEV Omega Ratio Rank: 5
MDEV Calmar Ratio Rank: 5
MDEV Martin Ratio Rank: 4

SBIO

SBIO Risk / Return Rank: 72
SBIO Sharpe Ratio Rank: 67
SBIO Sortino Ratio Rank: 67
SBIO Omega Ratio Rank: 59
SBIO Calmar Ratio Rank: 88
SBIO Martin Ratio Rank: 79

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

MDEV vs. SBIO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for First Trust Indxx Medical Devices ETF (MDEV) and ALPS Medical Breakthroughs ETF (SBIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	MDEV	SBIO	Difference
Sharpe ratio: Return per unit of total volatility	-0.44	2.24	-2.68
Sortino ratio: Return per unit of downside risk	-0.53	3.10	-3.63
Omega ratio: Gain probability vs. loss probability	0.94	1.36	-0.42
Calmar ratio: Return relative to maximum drawdown	-0.39	5.19	-5.58
Martin ratio: Return relative to average drawdown	-0.98	15.57	-16.54
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

MDEV vs. SBIO - Sharpe Ratio Comparison

The current MDEV Sharpe Ratio is -0.44, which is lower than the SBIO Sharpe Ratio of 2.24. The chart below compares the historical Sharpe Ratios of MDEV and SBIO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	MDEV	SBIO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.44	2.24	-2.68
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.08	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.24	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.32	0.21	-0.53

Drawdowns

MDEV vs. SBIO - Drawdown Comparison

The maximum MDEV drawdown since its inception was -42.34%, smaller than the maximum SBIO drawdown of -63.06%. Use the drawdown chart below to compare losses from any high point for MDEV and SBIO.

Drawdown Indicators

	MDEV	SBIO	Difference
Max Drawdown Largest peak-to-trough decline	-42.34%	-63.06%	+20.72%
Max Drawdown (1Y) Largest decline over 1 year	-18.13%	-12.66%	-5.47%
Max Drawdown (3Y) Largest decline over 3 years	-22.50%	-42.44%	+19.94%
Max Drawdown (5Y) Largest decline over 5 years	—	-53.10%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-63.06%	—
Current Drawdown Current decline from peak	-33.76%	-16.79%	-16.97%
Average Drawdown Average peak-to-trough decline	-25.65%	-28.45%	+2.80%
Ulcer Index Depth and duration of drawdowns from previous peaks	7.22%	4.22%	+3.00%

Volatility

MDEV vs. SBIO - Volatility Comparison

The current volatility for First Trust Indxx Medical Devices ETF (MDEV) is 4.60%, while ALPS Medical Breakthroughs ETF (SBIO) has a volatility of 9.48%. This indicates that MDEV experiences smaller price fluctuations and is considered to be less risky than SBIO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	MDEV	SBIO	Difference
Volatility (1M) Calculated over the trailing 1-month period	4.60%	9.48%	-4.88%
Volatility (6M) Calculated over the trailing 6-month period	11.42%	22.70%	-11.28%
Volatility (1Y) Calculated over the trailing 1-year period	16.00%	29.42%	-13.42%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	18.98%	33.56%	-14.58%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	18.98%	33.17%	-14.19%

MDEV vs. SBIO - Expense Ratio Comparison

MDEV has a 0.70% expense ratio, which is higher than SBIO's 0.50% expense ratio.

Dividends

MDEV vs. SBIO - Dividend Comparison

Neither MDEV nor SBIO has paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017
MDEV First Trust Indxx Medical Devices ETF	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%

Frequently Asked Questions

Can I hold both MDEV and SBIO in my portfolio?

MDEV and SBIO have a correlation of 0.41, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, MDEV or SBIO?

SBIO has higher volatility (9.48%) compared to MDEV (4.60%). In terms of maximum drawdown, MDEV dropped -42.34% vs SBIO's -63.06%.

Which ETF is better, MDEV or SBIO?

On 3-year performance, SBIO leads with 17.80% vs -2.86% for MDEV. On fees, SBIO is cheaper at 0.50% per year. On volatility, MDEV has been the lower-risk option at 4.60%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, MDEV or SBIO?

Over the 3-year period, SBIO has performed better with a 17.80% return vs -2.86%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, MDEV or SBIO?

SBIO is cheaper with a 0.50% expense ratio, compared with 0.70% for MDEV.

Which ETF pays a higher dividend yield, MDEV or SBIO?

MDEV and SBIO have nearly identical dividend yields, around 0.00%.

What is the main difference between MDEV and SBIO?

MDEV tracks Indxx Global Medical Equipment Index, while SBIO tracks S-Network Medical Breakthroughs Index. They also come from different issuers: First Trust and SS&C. Their fees differ too: 0.70% for MDEV and 0.50% for SBIO.

Which has better risk-adjusted returns?

SBIO currently has the higher Sharpe Ratio (2.24 vs -0.44), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.