LIFE.TO vs. XDNA.TO
LIFE.TO (Evolve Global Healthcare Enhanced Yield Fund) and XDNA.TO (iShares Genomics Immunology and Healthcare Index ETF) are both Health & Biotech Equities funds - LIFE.TO tracks the Solactive Global Healthcare 20 Index Canadian Dollar Hedged while XDNA.TO tracks the NYSE FactSet Global Genomics and Immuno Biopharma Index. Both are passively managed. Over the past 3 years, LIFE.TO returned 4.92%/yr vs 13.77%/yr for XDNA.TO. At a 0.20 correlation, their price movements are largely independent. LIFE.TO charges 0.65%/yr vs 0.44%/yr for XDNA.TO.
Performance
LIFE.TO vs. XDNA.TO - Performance Comparison
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Returns By Period
In the year-to-date period, LIFE.TO achieves a -1.74% return, which is significantly lower than XDNA.TO's 27.17% return.
LIFE.TO
- 1D
- 0.68%
- 1M
- 3.88%
- 6M
- -3.69%
- YTD
- -1.74%
- 1Y
- 6.84%
- 3Y*
- 4.92%
- 5Y*
- 4.41%
- 10Y*
- —
- ALL TIME*
- 7.58%
XDNA.TO
- 1D
- -0.55%
- 1M
- 0.76%
- 6M
- 11.88%
- YTD
- 27.17%
- 1Y
- 50.83%
- 3Y*
- 13.77%
- 5Y*
- —
- 10Y*
- —
- ALL TIME*
- 4.01%
Liquidity Comparison
| Position | Avg. Volume Value (2W) | Avg. Volume Value (1M) | Avg. Volume Value (3M) |
|---|---|---|---|
| CA$360.47K | CA$315.51K | CA$445.64K | |
| CA$126.40K | CA$124.25K | CA$58.28K |
LIFE.TO vs. XDNA.TO - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | |
|---|---|---|---|---|---|
LIFE.TO Evolve Global Healthcare Enhanced Yield Fund | -1.74% | 12.76% | 2.20% | 4.15% | 3.93% |
XDNA.TO iShares Genomics Immunology and Healthcare Index ETF | 27.17% | 12.10% | 5.54% | -7.84% | -14.85% |
Correlation
The correlation between LIFE.TO and XDNA.TO is 0.25, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.25 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.23 |
Correlation (All Time) Calculated using the full available price history since May 4, 2022 | 0.20 |
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Return for Risk
LIFE.TO vs. XDNA.TO — Risk / Return Rank
LIFE.TO
XDNA.TO
LIFE.TO vs. XDNA.TO - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Evolve Global Healthcare Enhanced Yield Fund (LIFE.TO) and iShares Genomics Immunology and Healthcare Index ETF (XDNA.TO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| LIFE.TO | XDNA.TO | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -1.68 | ||
| Sortino ratioReturn per unit of downside risk | -2.18 | ||
| Omega ratioGain probability vs. loss probability | 1.09 | 1.36 | -0.27 |
| Calmar ratioReturn relative to maximum drawdown | 0.52 | 6.32 | -5.81 |
| Martin ratioReturn relative to average drawdown | 1.20 | 14.00 | -12.80 |
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Drawdowns
LIFE.TO vs. XDNA.TO - Drawdown Comparison
The maximum LIFE.TO drawdown since its inception was -20.04%, smaller than the maximum XDNA.TO drawdown of -45.90%. Use the drawdown chart below to compare losses from any high point for LIFE.TO and XDNA.TO.
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Drawdown Indicators
| LIFE.TO | XDNA.TO | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -20.04% | -45.90% | +25.86% |
Max Drawdown (1Y)Largest decline over 1 year | -13.29% | -8.75% | -4.54% |
Max Drawdown (3Y)Largest decline over 3 years | -16.33% | -28.29% | +11.96% |
Max Drawdown (5Y)Largest decline over 5 years | -16.33% | — | — |
Current DrawdownCurrent decline from peak | -4.67% | -8.31% | +3.64% |
Average DrawdownAverage peak-to-trough decline | -4.35% | -22.90% | +18.55% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 5.73% | 3.95% | +1.78% |
Volatility
LIFE.TO vs. XDNA.TO - Volatility Comparison
The current volatility for Evolve Global Healthcare Enhanced Yield Fund (LIFE.TO) is 5.46%, while iShares Genomics Immunology and Healthcare Index ETF (XDNA.TO) has a volatility of 7.95%. This indicates that LIFE.TO experiences smaller price fluctuations and is considered to be less risky than XDNA.TO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| LIFE.TO | XDNA.TO | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 5.46% | 7.95% | -2.49% |
Volatility (6M)Calculated over the trailing 6-month period | 11.16% | 18.47% | -7.31% |
Volatility (1Y)Calculated over the trailing 1-year period | 14.75% | 25.78% | -11.03% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 13.62% | 25.39% | -11.77% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 15.01% | 25.39% | -10.38% |
LIFE.TO vs. XDNA.TO - Expense Ratio Comparison
LIFE.TO has a 0.65% expense ratio, which is higher than XDNA.TO's 0.44% expense ratio.
Dividends
LIFE.TO vs. XDNA.TO - Dividend Comparison
LIFE.TO's dividend yield for the trailing twelve months is around 12.82%, more than XDNA.TO's 0.25% yield.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 |
|---|---|---|---|---|---|---|---|---|---|
LIFE.TO Evolve Global Healthcare Enhanced Yield Fund | 12.82% | 11.83% | 10.90% | 9.24% | 8.20% | 6.46% | 7.09% | 6.33% | 4.84% |
XDNA.TO iShares Genomics Immunology and Healthcare Index ETF | 0.25% | 0.43% | 0.32% | 0.25% | 0.32% | 0.00% | 0.00% | 0.00% | 0.00% |
Frequently Asked Questions
LIFE.TO and XDNA.TO have a correlation of 0.25, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
On fees, XDNA.TO is cheaper at 0.44% per year. The better choice depends on whether you care most about return, fees, risk, or income.
XDNA.TO is cheaper with a 0.44% expense ratio, compared with 0.65% for LIFE.TO.
LIFE.TO tracks Solactive Global Healthcare 20 Index Canadian Dollar Hedged, while XDNA.TO tracks NYSE FactSet Global Genomics and Immuno Biopharma Index. They also come from different issuers: Evolve Funds Group Inc. and iShares. Their fees differ too: 0.65% for LIFE.TO and 0.44% for XDNA.TO.
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