KNSA vs. ANAB

Last updated Jun 20, 2026

KNSA (Kiniksa Pharmaceuticals, Ltd.) and ANAB (AnaptysBio, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, KNSA returned 29.69%/yr vs 28.81%/yr for ANAB. At a 0.30 correlation, their price movements are largely independent.

Performance

KNSA vs. ANAB - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Kiniksa Pharmaceuticals, Ltd. (KNSA) and AnaptysBio, Inc. (ANAB). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, KNSA achieves a 33.60% return, which is significantly lower than ANAB's 77.94% return.

KNSA

• 1D: 1.66%
• 1M: 3.51%
• YTD: 33.60%
• 6M: 27.60%
• 1Y: 93.78%
• 3Y*: 52.43%
• 5Y*: 29.69%
• 10Y*: —

ANAB

• 1D: 1.30%
• 1M: -3.68%
• YTD: 77.94%
• 6M: 75.76%
• 1Y: 272.31%
• 3Y*: 66.32%
• 5Y*: 28.81%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

KNSA vs. ANAB - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
KNSA Kiniksa Pharmaceuticals, Ltd.	33.60%	108.54%	12.77%	17.09%	27.27%	-33.39%	59.76%	-60.63%	14.89%
ANAB AnaptysBio, Inc.	77.94%	266.16%	-38.19%	-30.88%	-10.82%	61.63%	32.31%	-74.53%	-22.19%

Correlation

The correlation between KNSA and ANAB is 0.22, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.22
Correlation (3Y) Calculated over the trailing 3-year period	0.28
Correlation (5Y) Calculated over the trailing 5-year period	0.34
Correlation (All Time) Calculated using the full available price history since May 24, 2018	0.30

The correlation between KNSA and ANAB shifts across timeframes, from 0.22 (1 year) to 0.34 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap KNSA : $4.54B ANAB : $1.65B
EPS KNSA : $0.92 ANAB : -$0.91
PS Ratio KNSA : 5.80 ANAB : 7.29
PB Ratio KNSA : 7.50 ANAB : 129.44
Total Revenue (TTM) KNSA : $754.05M ANAB : $232.39M
Gross Profit (TTM) KNSA : $294.06M ANAB : $245.59M
EBITDA (TTM) KNSA : $101.06M ANAB : $52.72M

Return for Risk

KNSA vs. ANAB — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

KNSA

KNSA Risk / Return Rank: 92
KNSA Sharpe Ratio Rank: 91
KNSA Sortino Ratio Rank: 91
KNSA Omega Ratio Rank: 90
KNSA Calmar Ratio Rank: 91
KNSA Martin Ratio Rank: 94

ANAB

ANAB Risk / Return Rank: 96
ANAB Sharpe Ratio Rank: 98
ANAB Sortino Ratio Rank: 95
ANAB Omega Ratio Rank: 95
ANAB Calmar Ratio Rank: 97
ANAB Martin Ratio Rank: 97

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

KNSA vs. ANAB - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Kiniksa Pharmaceuticals, Ltd. (KNSA) and AnaptysBio, Inc. (ANAB). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	KNSA	ANAB	Difference
Sharpe ratio: Return per unit of total volatility	2.27	3.92	-1.65
Sortino ratio: Return per unit of downside risk	3.31	4.03	-0.72
Omega ratio: Gain probability vs. loss probability	1.41	1.54	-0.13
Calmar ratio: Return relative to maximum drawdown	4.63	9.62	-4.98
Martin ratio: Return relative to average drawdown	16.35	22.85	-6.50

KNSA vs. ANAB - Sharpe Ratio Comparison

The current KNSA Sharpe Ratio is 2.27, which is lower than the ANAB Sharpe Ratio of 3.92. The chart below compares the historical Sharpe Ratios of KNSA and ANAB, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

KNSA vs. ANAB - Drawdown Comparison

The maximum KNSA drawdown since its inception was -83.06%, smaller than the maximum ANAB drawdown of -92.08%. Use the drawdown chart below to compare losses from any high point for KNSA and ANAB.

Drawdown Indicators

	KNSA	ANAB	Difference
Max Drawdown Largest peak-to-trough decline	-83.06%	-92.08%	+9.02%
Max Drawdown (1Y) Largest decline over 1 year	-21.12%	-28.15%	+7.03%
Max Drawdown (3Y) Largest decline over 3 years	-34.14%	-69.32%	+35.18%
Max Drawdown (5Y) Largest decline over 5 years	-53.17%	-69.32%	+16.15%
Current Drawdown Current decline from peak	-7.35%	-32.89%	+25.54%
Average Drawdown Average peak-to-trough decline	-40.60%	-64.58%	+23.98%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.97%	11.83%	-5.86%

Volatility

KNSA vs. ANAB - Volatility Comparison

The current volatility for Kiniksa Pharmaceuticals, Ltd. (KNSA) is 10.40%, while AnaptysBio, Inc. (ANAB) has a volatility of 12.25%. This indicates that KNSA experiences smaller price fluctuations and is considered to be less risky than ANAB based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	KNSA	ANAB	Difference
Volatility (1M) Calculated over the trailing 1-month period	10.40%	12.25%	-1.85%
Volatility (6M) Calculated over the trailing 6-month period	34.02%	46.71%	-12.69%
Volatility (1Y) Calculated over the trailing 1-year period	43.03%	69.09%	-26.06%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	53.48%	65.38%	-11.90%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	63.93%	75.41%	-11.48%

Dividends

KNSA vs. ANAB - Dividend Comparison

Neither KNSA nor ANAB has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both KNSA and ANAB in my portfolio?

KNSA and ANAB have a correlation of 0.22, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, KNSA or ANAB?

ANAB has higher volatility (12.25%) compared to KNSA (10.40%). In terms of maximum drawdown, KNSA dropped -83.06% vs ANAB's -92.08%.

Which has better risk-adjusted returns?

ANAB currently has the higher Sharpe Ratio (3.92 vs 2.27), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.