JNGLX vs. VGHCX

Last updated Jun 4, 2026

JNGLX (Janus Henderson Global Life Sciences Fund) and VGHCX (Vanguard Health Care Fund Investor Shares) are both Health & Biotech Equities funds. Over the past 10 years, JNGLX returned 10.28%/yr vs 8.79%/yr for VGHCX. Their correlation of 0.87 suggests significant overlap in exposure. JNGLX charges 0.80%/yr vs 0.30%/yr for VGHCX.

Performance

JNGLX vs. VGHCX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Janus Henderson Global Life Sciences Fund (JNGLX) and Vanguard Health Care Fund Investor Shares (VGHCX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, JNGLX achieves a -3.59% return, which is significantly higher than VGHCX's -4.67% return. Over the past 10 years, JNGLX has outperformed VGHCX with an annualized return of 10.28%, while VGHCX has yielded a comparatively lower 8.79% annualized return.

JNGLX

• 1D: -2.62%
• 1M: -1.53%
• YTD: -3.59%
• 6M: -1.99%
• 1Y: 25.11%
• 3Y*: 9.32%
• 5Y*: 7.03%
• 10Y*: 10.28%

VGHCX

• 1D: -1.56%
• 1M: -1.40%
• YTD: -4.67%
• 6M: -4.29%
• 1Y: 16.18%
• 3Y*: 8.30%
• 5Y*: 7.16%
• 10Y*: 8.79%

*Multi-year figures are annualized to reflect compound growth (CAGR)

JNGLX vs. VGHCX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
JNGLX Janus Henderson Global Life Sciences Fund	-3.59%	24.84%	3.60%	7.51%	-2.69%	6.78%	25.66%	29.20%	4.17%	22.13%
VGHCX Vanguard Health Care Fund Investor Shares	-4.67%	19.63%	8.99%	5.46%	-1.05%	14.36%	12.57%	22.93%	1.03%	19.59%

Correlation

The correlation between JNGLX and VGHCX is 0.94, indicating a strong positive relationship between their price movements. Combining them offers limited diversification - they tend to fall together during downturns.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.94
Correlation (3Y) Calculated over the trailing 3-year period	0.92
Correlation (5Y) Calculated over the trailing 5-year period	0.93
Correlation (10Y) Calculated over the trailing 10-year period	0.91
Correlation (All Time) Calculated using the full available price history since Jan 5, 1999	0.87

The correlation between JNGLX and VGHCX has been stable across timeframes, ranging from 0.87 to 0.94 - a consistent structural relationship.

Return for Risk

JNGLX vs. VGHCX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

JNGLX

JNGLX Risk / Return Rank: 39
JNGLX Sharpe Ratio Rank: 36
JNGLX Sortino Ratio Rank: 37
JNGLX Omega Ratio Rank: 33
JNGLX Calmar Ratio Rank: 48
JNGLX Martin Ratio Rank: 39

VGHCX

VGHCX Risk / Return Rank: 17
VGHCX Sharpe Ratio Rank: 15
VGHCX Sortino Ratio Rank: 16
VGHCX Omega Ratio Rank: 14
VGHCX Calmar Ratio Rank: 22
VGHCX Martin Ratio Rank: 16

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

JNGLX vs. VGHCX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Janus Henderson Global Life Sciences Fund (JNGLX) and Vanguard Health Care Fund Investor Shares (VGHCX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	JNGLX	VGHCX	Difference
Sharpe ratio: Return per unit of total volatility	1.73	1.08	+0.65
Sortino ratio: Return per unit of downside risk	2.53	1.67	+0.86
Omega ratio: Gain probability vs. loss probability	1.30	1.19	+0.11
Calmar ratio: Return relative to maximum drawdown	2.65	1.73	+0.92
Martin ratio: Return relative to average drawdown	8.47	4.60	+3.87
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

JNGLX vs. VGHCX - Sharpe Ratio Comparison

The current JNGLX Sharpe Ratio is 1.73, which is higher than the VGHCX Sharpe Ratio of 1.08. The chart below compares the historical Sharpe Ratios of JNGLX and VGHCX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	JNGLX	VGHCX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.73	1.08	+0.65
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.45	0.40	+0.05
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.59	0.50	+0.09
Sharpe Ratio (All Time) Calculated using the full available price history	0.57	0.92	-0.36

Drawdowns

JNGLX vs. VGHCX - Drawdown Comparison

The maximum JNGLX drawdown since its inception was -59.00%, which is greater than VGHCX's maximum drawdown of -36.93%. Use the drawdown chart below to compare losses from any high point for JNGLX and VGHCX.

Drawdown Indicators

	JNGLX	VGHCX	Difference
Max Drawdown Largest peak-to-trough decline	-59.00%	-36.93%	-22.07%
Max Drawdown (1Y) Largest decline over 1 year	-9.68%	-9.20%	-0.48%
Max Drawdown (3Y) Largest decline over 3 years	-21.17%	-16.08%	-5.09%
Max Drawdown (5Y) Largest decline over 5 years	-22.21%	-16.95%	-5.26%
Max Drawdown (10Y) Largest decline over 10 years	-27.37%	-27.18%	-0.19%
Current Drawdown Current decline from peak	-6.49%	-7.61%	+1.12%
Average Drawdown Average peak-to-trough decline	-17.65%	-5.25%	-12.40%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.02%	3.44%	-0.42%

Volatility

JNGLX vs. VGHCX - Volatility Comparison

Janus Henderson Global Life Sciences Fund (JNGLX) has a higher volatility of 4.69% compared to Vanguard Health Care Fund Investor Shares (VGHCX) at 3.79%. This indicates that JNGLX's price experiences larger fluctuations and is considered to be riskier than VGHCX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	JNGLX	VGHCX	Difference
Volatility (1M) Calculated over the trailing 1-month period	4.69%	3.79%	+0.90%
Volatility (6M) Calculated over the trailing 6-month period	10.95%	10.35%	+0.60%
Volatility (1Y) Calculated over the trailing 1-year period	14.85%	14.75%	+0.10%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	15.85%	18.21%	-2.36%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	17.38%	17.64%	-0.26%

JNGLX vs. VGHCX - Expense Ratio Comparison

JNGLX has a 0.80% expense ratio, which is higher than VGHCX's 0.30% expense ratio.

Dividends

JNGLX vs. VGHCX - Dividend Comparison

JNGLX's dividend yield for the trailing twelve months is around 4.73%, less than VGHCX's 6.93% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
JNGLX Janus Henderson Global Life Sciences Fund	4.73%	4.56%	5.84%	4.26%	0.25%	9.85%	7.80%	6.23%	13.32%	0.89%	0.30%	8.81%
VGHCX Vanguard Health Care Fund Investor Shares	6.93%	6.00%	22.72%	7.17%	5.44%	8.31%	7.96%	11.82%	9.10%	7.30%	8.54%	8.16%

Frequently Asked Questions

Can I hold both JNGLX and VGHCX in my portfolio?

With a correlation of 0.94, JNGLX and VGHCX move almost identically. Holding both adds very little diversification - you're essentially doubling your position in the same market segment. Choosing one is usually more capital-efficient.

Which is riskier, JNGLX or VGHCX?

JNGLX has higher volatility (4.69%) compared to VGHCX (3.79%). In terms of maximum drawdown, JNGLX dropped -59.00% vs VGHCX's -36.93%.

Which has better risk-adjusted returns?

JNGLX currently has the higher Sharpe Ratio (1.73 vs 1.08), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.