JANRX vs. JAGLX

Last updated Jul 11, 2026

JANRX (Janus Henderson Global Select Fund) and JAGLX (Janus Henderson Global Life Sciences Fund Class T) are both mutual funds - JANRX is a Global Equities fund managed by Janus Henderson, while JAGLX is a Health & Biotech Equities fund actively managed by Janus Henderson. Over the past 10 years, JANRX returned 13.46%/yr vs 12.42%/yr for JAGLX. A 0.70 correlation means they provide meaningful diversification when combined. JANRX charges 0.82%/yr vs 0.92%/yr for JAGLX.

Performance

JANRX vs. JAGLX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Janus Henderson Global Select Fund (JANRX) and Janus Henderson Global Life Sciences Fund Class T (JAGLX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, JANRX achieves a 9.72% return, which is significantly lower than JAGLX's 11.64% return. Over the past 10 years, JANRX has outperformed JAGLX with an annualized return of 13.46%, while JAGLX has yielded a comparatively lower 12.42% annualized return.

JANRX

• 1D: 0.47%
• 1M: 1.19%
• 6M: 6.15%
• YTD: 9.72%
• 1Y: 16.95%
• 3Y*: 19.01%
• 5Y*: 10.49%
• 10Y*: 13.46%

JAGLX

• 1D: 0.13%
• 1M: 9.86%
• 6M: 9.74%
• YTD: 11.64%
• 1Y: 41.90%
• 3Y*: 17.02%
• 5Y*: 9.85%
• 10Y*: 12.42%

*Multi-year figures are annualized to reflect compound growth (CAGR)

JANRX vs. JAGLX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
JANRX Janus Henderson Global Select Fund	9.72%	19.49%	17.21%	17.41%	-9.94%	15.96%	16.14%	27.43%	-9.80%	31.08%
JAGLX Janus Henderson Global Life Sciences Fund Class T	11.64%	24.72%	8.50%	7.41%	-2.79%	6.66%	25.52%	29.12%	4.05%	22.13%

Correlation

The correlation between JANRX and JAGLX is 0.40, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.40
Correlation (3Y) Calculated over the trailing 3-year period	0.53
Correlation (5Y) Calculated over the trailing 5-year period	0.62
Correlation (10Y) Calculated over the trailing 10-year period	0.65
Correlation (All Time) Calculated using the full available price history since Jul 5, 2000	0.70

Over the past year, the correlation between JANRX and JAGLX has dropped to 0.40 - well below their long-term average of 0.70, suggesting their price drivers have been diverging.

Return for Risk

JANRX vs. JAGLX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

JANRX

JANRX Risk / Return Rank: 37
JANRX Sharpe Ratio Rank: 35
JANRX Sortino Ratio Rank: 34
JANRX Omega Ratio Rank: 36
JANRX Calmar Ratio Rank: 34
JANRX Martin Ratio Rank: 45

JAGLX

JAGLX Risk / Return Rank: 91
JAGLX Sharpe Ratio Rank: 94
JAGLX Sortino Ratio Rank: 91
JAGLX Omega Ratio Rank: 85
JAGLX Calmar Ratio Rank: 94
JAGLX Martin Ratio Rank: 90

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

JANRX vs. JAGLX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Janus Henderson Global Select Fund (JANRX) and Janus Henderson Global Life Sciences Fund Class T (JAGLX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	JANRX	JAGLX	Difference
Sharpe ratio: Return per unit of total volatility	1.31	2.64	-1.34
Sortino ratio: Return per unit of downside risk	1.87	3.80	-1.93
Omega ratio: Gain probability vs. loss probability	1.24	1.45	-0.21
Calmar ratio: Return relative to maximum drawdown	1.74	4.28	-2.54
Martin ratio: Return relative to average drawdown	7.47	13.60	-6.14

JANRX vs. JAGLX - Sharpe Ratio Comparison

The current JANRX Sharpe Ratio is 1.31, which is lower than the JAGLX Sharpe Ratio of 2.64. The chart below compares the historical Sharpe Ratios of JANRX and JAGLX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

JANRX vs. JAGLX - Drawdown Comparison

The maximum JANRX drawdown since its inception was -63.94%, which is greater than JAGLX's maximum drawdown of -58.96%. Use the drawdown chart below to compare losses from any high point for JANRX and JAGLX.

Drawdown Indicators

	JANRX	JAGLX	Difference
Max Drawdown Largest peak-to-trough decline	-63.94%	-58.96%	-4.98%
Max Drawdown (1Y) Largest decline over 1 year	-9.67%	-9.71%	+0.04%
Max Drawdown (3Y) Largest decline over 3 years	-19.56%	-17.41%	-2.15%
Max Drawdown (5Y) Largest decline over 5 years	-23.48%	-22.25%	-1.23%
Max Drawdown (10Y) Largest decline over 10 years	-39.17%	-27.38%	-11.79%
Current Drawdown Current decline from peak	-0.79%	-0.58%	-0.21%
Average Drawdown Average peak-to-trough decline	-17.73%	-17.37%	-0.36%
Ulcer Index Depth and duration of drawdowns from previous peaks	2.25%	3.05%	-0.80%

Volatility

JANRX vs. JAGLX - Volatility Comparison

Janus Henderson Global Select Fund (JANRX) and Janus Henderson Global Life Sciences Fund Class T (JAGLX) have volatilities of 5.50% and 5.47%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	JANRX	JAGLX	Difference
Volatility (1M) Calculated over the trailing 1-month period	5.50%	5.47%	+0.03%
Volatility (6M) Calculated over the trailing 6-month period	11.17%	12.14%	-0.97%
Volatility (1Y) Calculated over the trailing 1-year period	12.92%	15.83%	-2.91%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	16.35%	16.13%	+0.22%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	17.88%	17.38%	+0.50%

JANRX vs. JAGLX - Expense Ratio Comparison

JANRX has a 0.82% expense ratio, which is lower than JAGLX's 0.92% expense ratio.

Dividends

JANRX vs. JAGLX - Dividend Comparison

JANRX's dividend yield for the trailing twelve months is around 9.76%, more than JAGLX's 4.05% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
JAGLX Janus Henderson Global Life Sciences Fund Class T	4.05%	4.53%	10.98%	4.22%	0.14%	9.78%	7.75%	6.17%	13.38%	0.89%	1.13%	9.09%
JANRX Janus Henderson Global Select Fund	9.76%	10.71%	10.44%	8.62%	2.81%	13.04%	5.11%	4.37%	17.07%	0.86%	1.14%	1.08%

Frequently Asked Questions

Can I hold both JANRX and JAGLX in my portfolio?

JANRX and JAGLX have a correlation of 0.40, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, JANRX or JAGLX?

JANRX has higher volatility (5.50%) compared to JAGLX (5.47%). In terms of maximum drawdown, JANRX dropped -63.94% vs JAGLX's -58.96%.

Which has better risk-adjusted returns?

JAGLX currently has the higher Sharpe Ratio (2.64 vs 1.31), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.