JAGLX vs. PDFDX

Last updated Jul 16, 2026

JAGLX (Janus Henderson Global Life Sciences Fund Class T) and PDFDX (Perkins Discovery Fund) are both Health & Biotech Equities funds. Over the past 10 years, JAGLX returned 11.97%/yr vs 10.30%/yr for PDFDX. A 0.60 correlation means they provide meaningful diversification when combined. JAGLX charges 0.92%/yr vs 2.50%/yr for PDFDX.

Performance

JAGLX vs. PDFDX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Janus Henderson Global Life Sciences Fund Class T (JAGLX) and Perkins Discovery Fund (PDFDX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, JAGLX achieves a 7.67% return, which is significantly higher than PDFDX's 4.76% return. Over the past 10 years, JAGLX has outperformed PDFDX with an annualized return of 11.97%, while PDFDX has yielded a comparatively lower 10.30% annualized return.

JAGLX

• 1D: -1.27%
• 1M: 6.02%
• 6M: 5.17%
• YTD: 7.67%
• 1Y: 38.22%
• 3Y*: 15.10%
• 5Y*: 9.47%
• 10Y*: 11.97%

PDFDX

• 1D: -0.22%
• 1M: 1.26%
• 6M: 0.27%
• YTD: 4.76%
• 1Y: 32.74%
• 3Y*: 8.79%
• 5Y*: -5.66%
• 10Y*: 10.30%

*Multi-year figures are annualized to reflect compound growth (CAGR)

JAGLX vs. PDFDX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
JAGLX Janus Henderson Global Life Sciences Fund Class T	7.67%	24.72%	8.50%	7.41%	-2.79%	6.66%	25.52%	29.12%	4.05%	22.13%
PDFDX Perkins Discovery Fund	4.76%	9.94%	19.19%	10.77%	-39.93%	2.11%	62.16%	15.01%	22.19%	11.58%

Correlation

The correlation between JAGLX and PDFDX is 0.41, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.41
Correlation (3Y) Calculated over the trailing 3-year period	0.53
Correlation (5Y) Calculated over the trailing 5-year period	0.64
Correlation (10Y) Calculated over the trailing 10-year period	0.66
Correlation (All Time) Calculated using the full available price history since Dec 31, 1998	0.60

The correlation between JAGLX and PDFDX shifts across timeframes, from 0.41 (1 year) to 0.66 (10 years), reflecting how their relationship changes across market environments.

Return for Risk

JAGLX vs. PDFDX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

JAGLX

JAGLX Risk / Return Rank: 85
JAGLX Sharpe Ratio Rank: 86
JAGLX Sortino Ratio Rank: 86
JAGLX Omega Ratio Rank: 79
JAGLX Calmar Ratio Rank: 91
JAGLX Martin Ratio Rank: 84

PDFDX

PDFDX Risk / Return Rank: 27
PDFDX Sharpe Ratio Rank: 29
PDFDX Sortino Ratio Rank: 34
PDFDX Omega Ratio Rank: 28
PDFDX Calmar Ratio Rank: 24
PDFDX Martin Ratio Rank: 21

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

JAGLX vs. PDFDX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Janus Henderson Global Life Sciences Fund Class T (JAGLX) and Perkins Discovery Fund (PDFDX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	JAGLX	PDFDX	Difference
Sharpe ratio: Return per unit of total volatility	2.27	1.17	+1.10
Sortino ratio: Return per unit of downside risk	3.32	1.86	+1.46
Omega ratio: Gain probability vs. loss probability	1.39	1.21	+0.18
Calmar ratio: Return relative to maximum drawdown	3.72	1.36	+2.35
Martin ratio: Return relative to average drawdown	11.77	3.84	+7.92

JAGLX vs. PDFDX - Sharpe Ratio Comparison

The current JAGLX Sharpe Ratio is 2.27, which is higher than the PDFDX Sharpe Ratio of 1.17. The chart below compares the historical Sharpe Ratios of JAGLX and PDFDX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

JAGLX vs. PDFDX - Drawdown Comparison

The maximum JAGLX drawdown since its inception was -58.96%, smaller than the maximum PDFDX drawdown of -67.44%. Use the drawdown chart below to compare losses from any high point for JAGLX and PDFDX.

Drawdown Indicators

	JAGLX	PDFDX	Difference
Max Drawdown Largest peak-to-trough decline	-58.96%	-67.44%	+8.48%
Max Drawdown (1Y) Largest decline over 1 year	-9.71%	-22.11%	+12.40%
Max Drawdown (3Y) Largest decline over 3 years	-17.41%	-31.75%	+14.34%
Max Drawdown (5Y) Largest decline over 5 years	-22.25%	-59.95%	+37.70%
Max Drawdown (10Y) Largest decline over 10 years	-27.38%	-62.70%	+35.32%
Current Drawdown Current decline from peak	-4.11%	-32.87%	+28.76%
Average Drawdown Average peak-to-trough decline	-17.36%	-25.74%	+8.38%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.06%	7.82%	-4.76%

Volatility

JAGLX vs. PDFDX - Volatility Comparison

Janus Henderson Global Life Sciences Fund Class T (JAGLX) has a higher volatility of 5.70% compared to Perkins Discovery Fund (PDFDX) at 4.02%. This indicates that JAGLX's price experiences larger fluctuations and is considered to be riskier than PDFDX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	JAGLX	PDFDX	Difference
Volatility (1M) Calculated over the trailing 1-month period	5.70%	4.02%	+1.68%
Volatility (6M) Calculated over the trailing 6-month period	12.17%	17.77%	-5.60%
Volatility (1Y) Calculated over the trailing 1-year period	15.87%	25.79%	-9.92%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	16.15%	29.75%	-13.60%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	17.40%	28.92%	-11.52%

JAGLX vs. PDFDX - Expense Ratio Comparison

JAGLX has a 0.92% expense ratio, which is lower than PDFDX's 2.50% expense ratio.

Dividends

JAGLX vs. PDFDX - Dividend Comparison

JAGLX's dividend yield for the trailing twelve months is around 4.20%, less than PDFDX's 9.34% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
JAGLX Janus Henderson Global Life Sciences Fund Class T	4.20%	4.53%	10.98%	4.22%	0.14%	9.78%	7.75%	6.17%	13.38%	0.89%	1.13%	9.09%
PDFDX Perkins Discovery Fund	9.34%	4.25%	0.00%	0.00%	1.78%	31.11%	1.71%	0.00%	0.58%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both JAGLX and PDFDX in my portfolio?

JAGLX and PDFDX have a correlation of 0.41, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, JAGLX or PDFDX?

JAGLX has higher volatility (5.70%) compared to PDFDX (4.02%). In terms of maximum drawdown, JAGLX dropped -58.96% vs PDFDX's -67.44%.

Which has better risk-adjusted returns?

JAGLX currently has the higher Sharpe Ratio (2.27 vs 1.17), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.