IXJ vs. SBIO

Last updated Jun 4, 2026

IXJ (iShares Global Healthcare ETF) and SBIO (ALPS Medical Breakthroughs ETF) are both Health & Biotech Equities funds - IXJ tracks the S&P Global Healthcare Sector Index while SBIO tracks the S-Network Medical Breakthroughs Index. Both are passively managed. Over the past 10 years, IXJ returned 7.66%/yr vs 8.02%/yr for SBIO. A 0.57 correlation means they provide meaningful diversification when combined. IXJ charges 0.46%/yr vs 0.50%/yr for SBIO.

Performance

IXJ vs. SBIO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in iShares Global Healthcare ETF (IXJ) and ALPS Medical Breakthroughs ETF (SBIO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, IXJ achieves a -5.26% return, which is significantly lower than SBIO's -0.39% return. Both investments have delivered pretty close results over the past 10 years, with IXJ having a 7.66% annualized return and SBIO not far ahead at 8.02%.

IXJ

• 1D: 0.39%
• 1M: 0.34%
• YTD: -5.26%
• 6M: -4.88%
• 1Y: 9.30%
• 3Y*: 4.42%
• 5Y*: 4.02%
• 10Y*: 7.66%

SBIO

• 1D: 1.41%
• 1M: -7.56%
• YTD: -0.39%
• 6M: 3.05%
• 1Y: 65.41%
• 3Y*: 17.80%
• 5Y*: 2.68%
• 10Y*: 8.02%

*Multi-year figures are annualized to reflect compound growth (CAGR)

IXJ vs. SBIO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
IXJ iShares Global Healthcare ETF	-5.26%	14.99%	0.55%	3.62%	-4.94%	19.60%	12.74%	23.23%	2.83%	20.44%
SBIO ALPS Medical Breakthroughs ETF	-0.39%	55.07%	3.81%	8.68%	-28.08%	-17.55%	21.17%	50.30%	-11.81%	45.67%

Correlation

The correlation between IXJ and SBIO is 0.50, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.50
Correlation (3Y) Calculated over the trailing 3-year period	0.48
Correlation (5Y) Calculated over the trailing 5-year period	0.50
Correlation (10Y) Calculated over the trailing 10-year period	0.55
Correlation (All Time) Calculated using the full available price history since Jan 2, 2015	0.57

The correlation between IXJ and SBIO has been stable across timeframes, ranging from 0.48 to 0.57 - a consistent structural relationship.

IXJ vs. SBIO - Sectors Allocation Comparison

Sectors	IXJ	SBIO
Healthcare	98.9%	100.0%
Consumer Defensive	0.5%	-
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Energy	-	-
Financial Services	-	-0.0%
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

IXJ vs. SBIO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IXJ

IXJ Risk / Return Rank: 19
IXJ Sharpe Ratio Rank: 19
IXJ Sortino Ratio Rank: 20
IXJ Omega Ratio Rank: 18
IXJ Calmar Ratio Rank: 20
IXJ Martin Ratio Rank: 19

SBIO

SBIO Risk / Return Rank: 72
SBIO Sharpe Ratio Rank: 67
SBIO Sortino Ratio Rank: 67
SBIO Omega Ratio Rank: 59
SBIO Calmar Ratio Rank: 88
SBIO Martin Ratio Rank: 79

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IXJ vs. SBIO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for iShares Global Healthcare ETF (IXJ) and ALPS Medical Breakthroughs ETF (SBIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	IXJ	SBIO	Difference
Sharpe ratio Return per unit of total volatility	0.64	2.24	-1.60
Sortino ratio Return per unit of downside risk	1.06	3.10	-2.04
Omega ratio Gain probability vs. loss probability	1.12	1.36	-0.24
Calmar ratio Return relative to maximum drawdown	0.87	5.19	-4.33
Martin ratio Return relative to average drawdown	2.11	15.57	-13.45
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

IXJ vs. SBIO - Sharpe Ratio Comparison

The current IXJ Sharpe Ratio is 0.64, which is lower than the SBIO Sharpe Ratio of 2.24. The chart below compares the historical Sharpe Ratios of IXJ and SBIO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	IXJ	SBIO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.64	2.24	-1.60
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.28	0.08	+0.20
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.49	0.24	+0.25
Sharpe Ratio (All Time) Calculated using the full available price history	0.42	0.21	+0.20

Drawdowns

IXJ vs. SBIO - Drawdown Comparison

The maximum IXJ drawdown since its inception was -40.60%, smaller than the maximum SBIO drawdown of -63.06%. Use the drawdown chart below to compare losses from any high point for IXJ and SBIO.

Drawdown Indicators

	IXJ	SBIO	Difference
Max Drawdown Largest peak-to-trough decline	-40.60%	-63.06%	+22.46%
Max Drawdown (1Y) Largest decline over 1 year	-10.78%	-12.66%	+1.88%
Max Drawdown (3Y) Largest decline over 3 years	-18.14%	-42.44%	+24.30%
Max Drawdown (5Y) Largest decline over 5 years	-18.14%	-53.10%	+34.96%
Max Drawdown (10Y) Largest decline over 10 years	-27.35%	-63.06%	+35.71%
Current Drawdown Current decline from peak	-9.27%	-16.79%	+7.52%
Average Drawdown Average peak-to-trough decline	-6.92%	-28.45%	+21.53%
Ulcer Index Depth and duration of drawdowns from previous peaks	4.41%	4.22%	+0.19%

Volatility

IXJ vs. SBIO - Volatility Comparison

The current volatility for iShares Global Healthcare ETF (IXJ) is 3.75%, while ALPS Medical Breakthroughs ETF (SBIO) has a volatility of 9.48%. This indicates that IXJ experiences smaller price fluctuations and is considered to be less risky than SBIO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IXJ	SBIO	Difference
Volatility (1M) Calculated over the trailing 1-month period	3.75%	9.48%	-5.73%
Volatility (6M) Calculated over the trailing 6-month period	10.05%	22.70%	-12.65%
Volatility (1Y) Calculated over the trailing 1-year period	14.55%	29.42%	-14.87%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	14.21%	33.56%	-19.35%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	15.67%	33.17%	-17.50%

IXJ vs. SBIO - Expense Ratio Comparison

IXJ has a 0.46% expense ratio, which is lower than SBIO's 0.50% expense ratio.

Dividends

IXJ vs. SBIO - Dividend Comparison

IXJ's dividend yield for the trailing twelve months is around 1.47%, while SBIO has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
IXJ iShares Global Healthcare ETF	1.47%	1.40%	1.50%	1.38%	1.17%	1.12%	1.27%	1.42%	2.11%	1.46%	1.73%	2.85%
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%	0.00%	0.00%

Frequently Asked Questions

Can I hold both IXJ and SBIO in my portfolio?

IXJ and SBIO have a correlation of 0.50, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, IXJ or SBIO?

SBIO has higher volatility (9.48%) compared to IXJ (3.75%). In terms of maximum drawdown, IXJ dropped -40.60% vs SBIO's -63.06%.

Which ETF is better, IXJ or SBIO?

On 10-year performance, SBIO leads with 8.02% vs 7.66% for IXJ. On fees, IXJ is cheaper at 0.46% per year. On volatility, IXJ has been the lower-risk option at 3.75%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, IXJ or SBIO?

Over the 10-year period, SBIO has performed better with a 8.02% return vs 7.66%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, IXJ or SBIO?

IXJ is cheaper with a 0.46% expense ratio, compared with 0.50% for SBIO.

Which ETF pays a higher dividend yield, IXJ or SBIO?

IXJ has the higher dividend yield at 1.47%, compared with 0.00% for SBIO.

What is the main difference between IXJ and SBIO?

IXJ tracks S&P Global Healthcare Sector Index, while SBIO tracks S-Network Medical Breakthroughs Index. They also come from different issuers: iShares and SS&C. Their fees differ too: 0.46% for IXJ and 0.50% for SBIO.

Which has better risk-adjusted returns?

SBIO currently has the higher Sharpe Ratio (2.24 vs 0.64), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.