ITOL vs. CANC

Last updated Jun 4, 2026

ITOL (Tema International Durable Quality ETF) and CANC (Tema Oncology ETF) are both exchange-traded funds - ITOL is a Foreign Large Cap Equities fund actively managed by Tema, while CANC is a Health & Biotech Equities fund actively managed by Tema. Both are actively managed. At a 0.44 correlation, their price movements are largely independent. ITOL charges 0.60%/yr vs 0.75%/yr for CANC.

Performance

ITOL vs. CANC - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Tema International Durable Quality ETF (ITOL) and Tema Oncology ETF (CANC). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ITOL achieves a 0.58% return, which is significantly lower than CANC's 4.82% return.

ITOL

• 1D: 0.00%
• 1M: 1.19%
• YTD: 0.58%
• 6M: 3.05%
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

CANC

• 1D: 0.08%
• 1M: -3.73%
• YTD: 4.82%
• 6M: 3.86%
• 1Y: 47.37%
• 3Y*: 107.76%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

ITOL vs. CANC - Yearly Performance Comparison

	2026 (YTD)	2025
ITOL Tema International Durable Quality ETF	0.58%	3.85%
CANC Tema Oncology ETF	4.82%	25.08%

Correlation

The correlation between ITOL and CANC is 0.44, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (All Time) Calculated using the full available price history since Sep 12, 2025	0.44

Return for Risk

ITOL vs. CANC — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CANC

CANC Risk / Return Rank: 69
CANC Sharpe Ratio Rank: 61
CANC Sortino Ratio Rank: 64
CANC Omega Ratio Rank: 54
CANC Calmar Ratio Rank: 90
CANC Martin Ratio Rank: 77

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ITOL vs. CANC - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Tema International Durable Quality ETF (ITOL) and Tema Oncology ETF (CANC). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

Sharpe Ratios by Period

	ITOL	CANC	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	—	2.06	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.35	-0.04	+0.38

Drawdowns

ITOL vs. CANC - Drawdown Comparison

The maximum ITOL drawdown since its inception was -15.54%, smaller than the maximum CANC drawdown of -97.53%. Use the drawdown chart below to compare losses from any high point for ITOL and CANC.

Drawdown Indicators

	ITOL	CANC	Difference
Max Drawdown Largest peak-to-trough decline	-15.54%	-97.53%	+81.99%
Max Drawdown (1Y) Largest decline over 1 year	—	-8.67%	—
Max Drawdown (3Y) Largest decline over 3 years	—	-30.27%	—
Current Drawdown Current decline from peak	-5.46%	-56.55%	+51.09%
Average Drawdown Average peak-to-trough decline	-3.59%	-73.19%	+69.60%
Ulcer Index Depth and duration of drawdowns from previous peaks	—	3.25%	—

Volatility

Volatility by Period

	ITOL	CANC	Difference
Volatility (1M) Calculated over the trailing 1-month period	—	6.26%	—
Volatility (6M) Calculated over the trailing 6-month period	—	16.69%	—
Volatility (1Y) Calculated over the trailing 1-year period	17.90%	23.11%	-5.21%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	17.90%	280.27%	-262.37%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	17.90%	280.27%	-262.37%

ITOL vs. CANC - Expense Ratio Comparison

ITOL has a 0.60% expense ratio, which is lower than CANC's 0.75% expense ratio.

Dividends

ITOL vs. CANC - Dividend Comparison

ITOL's dividend yield for the trailing twelve months is around 0.13%, more than CANC's 0.05% yield.

Position	TTM	2025	2024	2023
CANC Tema Oncology ETF	0.05%	0.06%	3.00%	0.56%
ITOL Tema International Durable Quality ETF	0.13%	0.13%	0.00%	0.00%

Frequently Asked Questions

Can I hold both ITOL and CANC in my portfolio?

ITOL and CANC have a correlation of 0.44, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, ITOL or CANC?

On fees, ITOL is cheaper at 0.60% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, ITOL or CANC?

ITOL is cheaper with a 0.60% expense ratio, compared with 0.75% for CANC.

Which ETF pays a higher dividend yield, ITOL or CANC?

ITOL has the higher dividend yield at 0.13%, compared with 0.05% for CANC.

What is the main difference between ITOL and CANC?

ITOL is categorized as Foreign Large Cap Equities, while CANC is Health & Biotech Equities. Their fees differ too: 0.60% for ITOL and 0.75% for CANC.