CANC vs. VOO

Last updated Jun 23, 2026

CANC (Tema Oncology ETF) and VOO (Vanguard S&P 500 ETF) are both exchange-traded funds - CANC is a Health & Biotech Equities fund actively managed by Tema, while VOO is a S&P 500 fund tracking the S&P 500 Index. CANC is actively managed, while VOO is passively managed. Over the past 3 years, CANC returned 131.39%/yr vs 20.78%/yr for VOO. At a 0.39 correlation, their price movements are largely independent. CANC charges 0.75%/yr vs 0.03%/yr for VOO.

Performance

CANC vs. VOO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Tema Oncology ETF (CANC) and Vanguard S&P 500 ETF (VOO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CANC achieves a 9.70% return, which is significantly higher than VOO's 8.19% return.

CANC

• 1D: 2.41%
• 1M: -0.08%
• YTD: 9.70%
• 6M: 7.59%
• 1Y: 56.31%
• 3Y*: 131.39%
• 5Y*: —
• 10Y*: —

VOO

• 1D: -1.42%
• 1M: -1.34%
• YTD: 8.19%
• 6M: 7.24%
• 1Y: 23.69%
• 3Y*: 20.78%
• 5Y*: 13.13%
• 10Y*: 15.61%

*Multi-year figures are annualized to reflect compound growth (CAGR)

CANC vs. VOO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
CANC Tema Oncology ETF	9.70%	42.92%	-5.37%	510.51%	-85.34%	-55.35%
VOO Vanguard S&P 500 ETF	8.19%	17.82%	24.98%	26.32%	-18.17%	9.69%

Correlation

The correlation between CANC and VOO is 0.43, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.43
Correlation (3Y) Calculated over the trailing 3-year period	0.48
Correlation (All Time) Calculated using the full available price history since Sep 30, 2021	0.39

CANC vs. VOO - Sectors Allocation Comparison

Sectors	CANC	VOO
Healthcare	100.0%	8.3%
Basic Materials	-	1.7%
Communication Services	-	10.5%
Consumer Cyclical	-	9.8%
Consumer Defensive	-	4.5%
Energy	-	3.2%
Financial Services	-	10.9%
Industrials	-	7.6%
Real Estate	-	1.8%
Technology	-	39.1%
Utilities	-	2.5%

Return for Risk

CANC vs. VOO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CANC

CANC Risk / Return Rank: 82
CANC Sharpe Ratio Rank: 81
CANC Sortino Ratio Rank: 83
CANC Omega Ratio Rank: 70
CANC Calmar Ratio Rank: 92
CANC Martin Ratio Rank: 84

VOO

VOO Risk / Return Rank: 59
VOO Sharpe Ratio Rank: 59
VOO Sortino Ratio Rank: 56
VOO Omega Ratio Rank: 58
VOO Calmar Ratio Rank: 56
VOO Martin Ratio Rank: 67

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CANC vs. VOO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Tema Oncology ETF (CANC) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	CANC	VOO	Difference
Sharpe ratio: Return per unit of total volatility	2.50	1.91	+0.58
Sortino ratio: Return per unit of downside risk	3.51	2.60	+0.91
Omega ratio: Gain probability vs. loss probability	1.40	1.35	+0.05
Calmar ratio: Return relative to maximum drawdown	6.08	2.67	+3.41
Martin ratio: Return relative to average drawdown	16.57	11.96	+4.61

CANC vs. VOO - Sharpe Ratio Comparison

The current CANC Sharpe Ratio is 2.50, which is higher than the VOO Sharpe Ratio of 1.91. The chart below compares the historical Sharpe Ratios of CANC and VOO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

CANC vs. VOO - Drawdown Comparison

The maximum CANC drawdown since its inception was -97.53%, which is greater than VOO's maximum drawdown of -33.99%. Use the drawdown chart below to compare losses from any high point for CANC and VOO.

Drawdown Indicators

	CANC	VOO	Difference
Max Drawdown Largest peak-to-trough decline	-97.53%	-33.99%	-63.54%
Max Drawdown (1Y) Largest decline over 1 year	-9.30%	-8.90%	-0.40%
Max Drawdown (3Y) Largest decline over 3 years	-30.27%	-18.69%	-11.58%
Max Drawdown (5Y) Largest decline over 5 years	—	-24.52%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-33.99%	—
Current Drawdown Current decline from peak	-54.53%	-3.14%	-51.39%
Average Drawdown Average peak-to-trough decline	-72.96%	-3.68%	-69.28%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.41%	1.99%	+1.42%

Volatility

CANC vs. VOO - Volatility Comparison

Tema Oncology ETF (CANC) has a higher volatility of 6.51% compared to Vanguard S&P 500 ETF (VOO) at 4.83%. This indicates that CANC's price experiences larger fluctuations and is considered to be riskier than VOO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CANC	VOO	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.51%	4.83%	+1.68%
Volatility (6M) Calculated over the trailing 6-month period	16.87%	9.82%	+7.05%
Volatility (1Y) Calculated over the trailing 1-year period	22.72%	12.46%	+10.26%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	278.76%	16.91%	+261.85%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	278.76%	18.02%	+260.74%

CANC vs. VOO - Expense Ratio Comparison

CANC has a 0.75% expense ratio, which is higher than VOO's 0.03% expense ratio.

Dividends

CANC vs. VOO - Dividend Comparison

CANC's dividend yield for the trailing twelve months is around 0.05%, less than VOO's 1.05% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
CANC Tema Oncology ETF	0.05%	0.06%	3.00%	0.56%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
VOO Vanguard S&P 500 ETF	1.05%	1.13%	1.24%	1.46%	1.69%	1.25%	1.54%	1.88%	2.06%	1.78%	2.02%	2.10%

Frequently Asked Questions

Can I hold both CANC and VOO in my portfolio?

CANC and VOO have a correlation of 0.43, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CANC or VOO?

CANC has higher volatility (6.51%) compared to VOO (4.83%). In terms of maximum drawdown, CANC dropped -97.53% vs VOO's -33.99%.

Which ETF is better, CANC or VOO?

On 3-year performance, CANC leads with 131.39% vs 20.78% for VOO. On fees, VOO is cheaper at 0.03% per year. On volatility, VOO has been the lower-risk option at 4.83%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, CANC or VOO?

Over the 3-year period, CANC has performed better with a 131.39% return vs 20.78%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, CANC or VOO?

VOO is cheaper with a 0.03% expense ratio, compared with 0.75% for CANC.

Which ETF pays a higher dividend yield, CANC or VOO?

VOO has the higher dividend yield at 1.05%, compared with 0.05% for CANC.

What is the main difference between CANC and VOO?

CANC is categorized as Health & Biotech Equities, while VOO is S&P 500. They also come from different issuers: Tema and Vanguard. Their fees differ too: 0.75% for CANC and 0.03% for VOO.

Which has better risk-adjusted returns?

CANC currently has the higher Sharpe Ratio (2.50 vs 1.91), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.