ISRG vs. EXEL
ISRG (Intuitive Surgical, Inc.) and EXEL (Exelixis, Inc.) are both stocks. Both are in the Healthcare sector — ISRG in Medical Instruments & Supplies, EXEL in Biotechnology. Over the past 10 years, ISRG returned 16.50%/yr vs 19.21%/yr for EXEL. Their 0.31 correlation means their historical movements had little consistent relationship.
Performance
ISRG vs. EXEL - Performance Comparison
Loading charts...
Returns By Period
In the year-to-date period, ISRG achieves a -37.61% return, which is significantly lower than EXEL's 20.99% return. Over the past 10 years, ISRG has underperformed EXEL with an annualized return of 16.50%, while EXEL has yielded a comparatively higher 19.21% annualized return.
ISRG
- 1D
- 0.10%
- 1M
- -12.19%
- 6M
- -29.93%
- YTD
- -37.61%
- 1Y
- -26.56%
- 3Y*
- 2.94%
- 5Y*
- 1.35%
- 10Y*
- 16.50%
- ALL TIME*
- 21.88%
EXEL
- 1D
- -5.25%
- 1M
- -1.72%
- 6M
- 28.22%
- YTD
- 20.99%
- 1Y
- 46.41%
- 3Y*
- 39.27%
- 5Y*
- 25.77%
- 10Y*
- 19.21%
- ALL TIME*
- 4.71%
Liquidity Comparison
| Position | Avg. Volume Value (2W) | Avg. Volume Value (1M) | Avg. Volume Value (3M) |
|---|---|---|---|
EXEL Exelixis, Inc. | $119.34M | $130.32M | $139.06M |
| $1.43B | $1.49B | $1.19B |
ISRG vs. EXEL - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
ISRG Intuitive Surgical, Inc. | -37.61% | 8.51% | 54.72% | 27.14% | -26.15% | 31.76% | 38.39% | 23.43% | 31.23% | 72.64% |
EXEL Exelixis, Inc. | 20.99% | 31.62% | 38.81% | 49.56% | -12.25% | -8.92% | 13.90% | -10.42% | -35.30% | 103.89% |
Correlation
The correlation between ISRG and EXEL is 0.25, which is low. Their historical price movements had little consistent relationship.
| Correlation | |
|---|---|
Correlation (1Y) Focuses on recent behavior, but can change the most. | 0.25 |
Correlation (3Y) Balances recent behavior with more history. | 0.26 |
Correlation (5Y) Shows whether the relationship held over a longer period. | 0.31 |
Correlation (10Y) Provides a long-term view across more market conditions. | 0.31 |
Correlation (All Time) Calculated using the full available price history since Jun 16, 2000 | 0.31 |
Fundamentals
ISRG:
$124.82B
EXEL:
$13.33B
ISRG:
$8.72
EXEL:
$3.02
ISRG:
40.54
EXEL:
17.56
ISRG:
2.48
EXEL:
0.31
ISRG:
11.53
EXEL:
6.16
ISRG:
6.92
EXEL:
7.32
ISRG:
$11.03B
EXEL:
$2.38B
ISRG:
$7.36B
EXEL:
$1.70B
ISRG:
$4.18B
EXEL:
$991.79M
Compare stocks, funds, or ETFs
Search for stocks, ETFs, and funds for a quick comparison or use the comparison tool for more options.
Return for Risk
ISRG vs. EXEL — Risk / Return Rank
ISRG
EXEL
ISRG vs. EXEL - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Intuitive Surgical, Inc. (ISRG) and Exelixis, Inc. (EXEL). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| ISRG | EXEL | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -2.08 | ||
| Sortino ratioReturn per unit of downside risk | -2.88 | ||
| Omega ratioGain probability vs. loss probability | 0.88 | 1.25 | -0.38 |
| Calmar ratioReturn relative to maximum drawdown | -0.61 | 2.83 | -3.44 |
| Martin ratioReturn relative to average drawdown | -1.40 | 8.84 | -10.24 |
Loading charts...
Drawdowns
ISRG vs. EXEL - Drawdown Comparison
The maximum ISRG drawdown since its inception was -82.26%, smaller than the maximum EXEL drawdown of -97.38%. Use the drawdown chart below to compare losses from any high point for ISRG and EXEL.
Loading charts...
Drawdown Indicators
| ISRG | EXEL | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -82.26% | -97.38% | +15.12% |
Max Drawdown (1Y)Largest decline over 1 year | -44.00% | -16.47% | -27.53% |
Max Drawdown (3Y)Largest decline over 3 years | -45.61% | -25.34% | -20.27% |
Max Drawdown (5Y)Largest decline over 5 years | -49.90% | -35.41% | -14.49% |
Max Drawdown (10Y)Largest decline over 10 years | -49.90% | -57.20% | +7.30% |
Current DrawdownCurrent decline from peak | -42.12% | -7.13% | -34.99% |
Average DrawdownAverage peak-to-trough decline | -21.36% | -70.68% | +49.32% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 19.01% | 5.27% | +13.74% |
Volatility
ISRG vs. EXEL - Volatility Comparison
Intuitive Surgical, Inc. (ISRG) has a higher volatility of 20.49% compared to Exelixis, Inc. (EXEL) at 8.73%. This indicates that ISRG's price experiences larger fluctuations and is considered to be riskier than EXEL based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
Loading charts...
Volatility by Period
| ISRG | EXEL | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 20.49% | 8.73% | +11.76% |
Volatility (6M)Calculated over the trailing 6-month period | 28.02% | 24.34% | +3.68% |
Volatility (1Y)Calculated over the trailing 1-year period | 35.93% | 35.10% | +0.83% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 34.29% | 35.68% | -1.39% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 32.94% | 44.47% | -11.53% |
Dividends
ISRG vs. EXEL - Dividend Comparison
Neither ISRG nor EXEL has paid dividends to shareholders.
Financials
ISRG vs. EXEL - Financials Comparison
This section allows you to compare key financial metrics between Intuitive Surgical, Inc. and Exelixis, Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
ISRG vs. EXEL - Profitability Comparison
ISRG - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Aug 2026, Intuitive Surgical, Inc. reported a gross profit of 1.96B and revenue of 2.89B. Therefore, the gross margin over that period was 67.8%.
EXEL - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Aug 2026, Exelixis, Inc. reported a gross profit of 0.00 and revenue of 610.81M. Therefore, the gross margin over that period was 0.0%.
ISRG - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Aug 2026, Intuitive Surgical, Inc. reported an operating income of 971.90M and revenue of 2.89B, resulting in an operating margin of 33.6%.
EXEL - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Aug 2026, Exelixis, Inc. reported an operating income of 251.34M and revenue of 610.81M, resulting in an operating margin of 41.2%.
ISRG - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Aug 2026, Intuitive Surgical, Inc. reported a net income of 818.10M and revenue of 2.89B, resulting in a net margin of 28.3%.
EXEL - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Aug 2026, Exelixis, Inc. reported a net income of 210.47M and revenue of 610.81M, resulting in a net margin of 34.5%.
Frequently Asked Questions
ISRG and EXEL have a correlation of 0.25, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
ISRG has higher volatility (20.49%) compared to EXEL (8.73%). In terms of maximum drawdown, ISRG dropped -82.26% vs EXEL's -97.38%.
EXEL currently has the higher Sharpe Ratio (1.33 vs -0.75), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
Find the right allocation for ISRG and EXEL
Add both to a portfolio and optimize allocations for your target — whether that's maximizing returns, minimizing drawdowns, or balancing risk across holdings.
Open Portfolio Optimizer