EXEL vs. CRSP

Last updated Jun 24, 2026

EXEL (Exelixis, Inc.) and CRSP (CRISPR Therapeutics AG) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, EXEL returned 17.56%/yr vs -17.10%/yr for CRSP. At a 0.33 correlation, their price movements are largely independent.

Performance

EXEL vs. CRSP - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Exelixis, Inc. (EXEL) and CRISPR Therapeutics AG (CRSP). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, EXEL achieves a 17.13% return, which is significantly higher than CRSP's 2.96% return.

EXEL

• 1D: -0.02%
• 1M: 2.37%
• YTD: 17.13%
• 6M: 10.15%
• 1Y: 18.38%
• 3Y*: 37.24%
• 5Y*: 17.56%
• 10Y*: 20.91%

CRSP

• 1D: -0.68%
• 1M: 7.21%
• YTD: 2.96%
• 6M: -4.37%
• 1Y: 18.53%
• 3Y*: -1.23%
• 5Y*: -17.10%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

EXEL vs. CRSP - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
EXEL Exelixis, Inc.	17.13%	31.62%	38.81%	49.56%	-12.25%	-8.92%	13.90%	-10.42%	-35.30%	103.89%
CRSP CRISPR Therapeutics AG	2.96%	33.23%	-37.12%	54.00%	-46.36%	-50.51%	151.39%	113.18%	21.68%	15.89%

Correlation

The correlation between EXEL and CRSP is 0.37, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.37
Correlation (3Y) Calculated over the trailing 3-year period	0.25
Correlation (5Y) Calculated over the trailing 5-year period	0.32
Correlation (All Time) Calculated using the full available price history since Oct 19, 2016	0.33

The correlation between EXEL and CRSP shifts across timeframes, from 0.25 (3 years) to 0.37 (1 year), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap EXEL : $13.72B CRSP : $5.19B
EPS EXEL : $3.00 CRSP : -$6.24
PS Ratio EXEL : 6.01 CRSP : 1.20K
PB Ratio EXEL : 7.09 CRSP : 2.86
Total Revenue (TTM) EXEL : $2.38B CRSP : $4.10M
Gross Profit (TTM) EXEL : $1.70B CRSP : -$171.17M
EBITDA (TTM) EXEL : $991.79M CRSP : -$509.21M

Return for Risk

EXEL vs. CRSP — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

EXEL

EXEL Risk / Return Rank: 57
EXEL Sharpe Ratio Rank: 58
EXEL Sortino Ratio Rank: 52
EXEL Omega Ratio Rank: 55
EXEL Calmar Ratio Rank: 58
EXEL Martin Ratio Rank: 61

CRSP

CRSP Risk / Return Rank: 52
CRSP Sharpe Ratio Rank: 53
CRSP Sortino Ratio Rank: 54
CRSP Omega Ratio Rank: 51
CRSP Calmar Ratio Rank: 53
CRSP Martin Ratio Rank: 51

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

EXEL vs. CRSP - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Exelixis, Inc. (EXEL) and CRISPR Therapeutics AG (CRSP). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	EXEL	CRSP	Difference
Sharpe ratio: Return per unit of total volatility	0.47	0.30	+0.17
Sortino ratio: Return per unit of downside risk	0.86	0.90	-0.04
Omega ratio: Gain probability vs. loss probability	1.13	1.10	+0.02
Calmar ratio: Return relative to maximum drawdown	0.73	0.44	+0.29
Martin ratio: Return relative to average drawdown	1.77	0.72	+1.05

EXEL vs. CRSP - Sharpe Ratio Comparison

The current EXEL Sharpe Ratio is 0.47, which is higher than the CRSP Sharpe Ratio of 0.30. The chart below compares the historical Sharpe Ratios of EXEL and CRSP, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

EXEL vs. CRSP - Drawdown Comparison

The maximum EXEL drawdown since its inception was -97.38%, which is greater than CRSP's maximum drawdown of -85.11%. Use the drawdown chart below to compare losses from any high point for EXEL and CRSP.

Drawdown Indicators

	EXEL	CRSP	Difference
Max Drawdown Largest peak-to-trough decline	-97.38%	-85.11%	-12.27%
Max Drawdown (1Y) Largest decline over 1 year	-25.16%	-42.25%	+17.09%
Max Drawdown (3Y) Largest decline over 3 years	-25.34%	-64.91%	+39.57%
Max Drawdown (5Y) Largest decline over 5 years	-36.12%	-80.68%	+44.56%
Max Drawdown (10Y) Largest decline over 10 years	-57.20%	—	—
Current Drawdown Current decline from peak	-4.04%	-74.30%	+70.26%
Average Drawdown Average peak-to-trough decline	-70.96%	-49.30%	-21.66%
Ulcer Index Depth and duration of drawdowns from previous peaks	10.42%	25.94%	-15.52%

Volatility

EXEL vs. CRSP - Volatility Comparison

The current volatility for Exelixis, Inc. (EXEL) is 9.38%, while CRISPR Therapeutics AG (CRSP) has a volatility of 17.81%. This indicates that EXEL experiences smaller price fluctuations and is considered to be less risky than CRSP based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	EXEL	CRSP	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.38%	17.81%	-8.43%
Volatility (6M) Calculated over the trailing 6-month period	25.53%	43.95%	-18.42%
Volatility (1Y) Calculated over the trailing 1-year period	40.28%	62.58%	-22.30%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	37.17%	60.72%	-23.55%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	44.48%	64.30%	-19.82%

Dividends

EXEL vs. CRSP - Dividend Comparison

Neither EXEL nor CRSP has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both EXEL and CRSP in my portfolio?

EXEL and CRSP have a correlation of 0.37, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, EXEL or CRSP?

CRSP has higher volatility (17.81%) compared to EXEL (9.38%). In terms of maximum drawdown, EXEL dropped -97.38% vs CRSP's -85.11%.

Which has better risk-adjusted returns?

EXEL currently has the higher Sharpe Ratio (0.47 vs 0.30), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.