ISRG vs. CRSP
ISRG (Intuitive Surgical, Inc.) and CRSP (CRISPR Therapeutics AG) are both stocks. Both are in the Healthcare sector — ISRG in Medical Instruments & Supplies, CRSP in Biotechnology. Over the past 5 years, ISRG returned 7.37%/yr vs -17.08%/yr for CRSP. At a 0.34 correlation, their price movements are largely independent.
Performance
ISRG vs. CRSP - Performance Comparison
Loading charts...
Returns By Period
In the year-to-date period, ISRG achieves a -27.42% return, which is significantly lower than CRSP's -5.03% return.
ISRG
- 1D
- -0.45%
- 1M
- -2.39%
- YTD
- -27.42%
- 6M
- -24.20%
- 1Y
- -19.74%
- 3Y*
- 9.23%
- 5Y*
- 7.37%
- 10Y*
- 19.09%
CRSP
- 1D
- -0.86%
- 1M
- 2.87%
- YTD
- -5.03%
- 6M
- -12.14%
- 1Y
- 20.41%
- 3Y*
- -6.43%
- 5Y*
- -17.08%
- 10Y*
- —
ISRG vs. CRSP - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
ISRG Intuitive Surgical, Inc. | -27.42% | 8.51% | 54.72% | 27.14% | -26.15% | 31.76% | 38.39% | 23.43% | 31.23% | 72.64% |
CRSP CRISPR Therapeutics AG | -5.03% | 33.23% | -37.12% | 54.00% | -46.36% | -50.51% | 151.39% | 113.18% | 21.68% | 15.89% |
Correlation
The correlation between ISRG and CRSP is 0.21, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.21 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.26 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.32 |
Correlation (All Time) Calculated using the full available price history since Oct 19, 2016 | 0.34 |
The correlation between ISRG and CRSP shifts across timeframes, from 0.21 (1 year) to 0.34 (all time), reflecting how their relationship changes across market environments.
Fundamentals
ISRG:
$147.90B
CRSP:
$4.78B
ISRG:
$8.24
CRSP:
-$6.24
ISRG:
14.04
CRSP:
1.11K
ISRG:
8.40
CRSP:
2.64
ISRG:
$10.58B
CRSP:
$4.10M
ISRG:
$7.02B
CRSP:
-$171.17M
ISRG:
$3.76B
CRSP:
-$509.21M
Compare stocks, funds, or ETFs
Search for stocks, ETFs, and funds for a quick comparison or use the comparison tool for more options.
Return for Risk
ISRG vs. CRSP — Risk / Return Rank
ISRG
CRSP
ISRG vs. CRSP - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Intuitive Surgical, Inc. (ISRG) and CRISPR Therapeutics AG (CRSP). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| ISRG | CRSP | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -0.98 | ||
| Sortino ratioReturn per unit of downside risk | -1.81 | ||
| Omega ratioGain probability vs. loss probability | 0.90 | 1.11 | -0.21 |
| Calmar ratioReturn relative to maximum drawdown | -0.62 | 0.49 | -1.11 |
| Martin ratioReturn relative to average drawdown | -1.24 | 0.81 | -2.05 |
Loading charts...
Drawdowns
ISRG vs. CRSP - Drawdown Comparison
The maximum ISRG drawdown since its inception was -82.26%, roughly equal to the maximum CRSP drawdown of -85.11%. Use the drawdown chart below to compare losses from any high point for ISRG and CRSP.
Loading charts...
Drawdown Indicators
| ISRG | CRSP | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -82.26% | -85.11% | +2.85% |
Max Drawdown (1Y)Largest decline over 1 year | -32.14% | -42.25% | +10.11% |
Max Drawdown (3Y)Largest decline over 3 years | -34.10% | -64.91% | +30.81% |
Max Drawdown (5Y)Largest decline over 5 years | -49.90% | -80.68% | +30.78% |
Max Drawdown (10Y)Largest decline over 10 years | -49.90% | — | — |
Current DrawdownCurrent decline from peak | -32.66% | -76.29% | +43.63% |
Average DrawdownAverage peak-to-trough decline | -21.28% | -49.24% | +27.96% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 16.00% | 25.51% | -9.51% |
Volatility
ISRG vs. CRSP - Volatility Comparison
The current volatility for Intuitive Surgical, Inc. (ISRG) is 9.70%, while CRISPR Therapeutics AG (CRSP) has a volatility of 18.22%. This indicates that ISRG experiences smaller price fluctuations and is considered to be less risky than CRSP based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
Loading charts...
Volatility by Period
| ISRG | CRSP | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 9.70% | 18.22% | -8.52% |
Volatility (6M)Calculated over the trailing 6-month period | 20.72% | 43.62% | -22.90% |
Volatility (1Y)Calculated over the trailing 1-year period | 30.69% | 62.44% | -31.75% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 33.19% | 60.65% | -27.46% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 32.40% | 64.35% | -31.95% |
Dividends
ISRG vs. CRSP - Dividend Comparison
Neither ISRG nor CRSP has paid dividends to shareholders.
Financials
ISRG vs. CRSP - Financials Comparison
This section allows you to compare key financial metrics between Intuitive Surgical, Inc. and CRISPR Therapeutics AG. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
Frequently Asked Questions
ISRG and CRSP have a correlation of 0.21, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
CRSP has higher volatility (18.22%) compared to ISRG (9.70%). In terms of maximum drawdown, ISRG dropped -82.26% vs CRSP's -85.11%.
CRSP currently has the higher Sharpe Ratio (0.33 vs -0.65), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
Find the right allocation for ISRG and CRSP
Add both to a portfolio and optimize allocations for your target — whether that's maximizing returns, minimizing drawdowns, or balancing risk across holdings.
Open Portfolio Optimizer