ISRG vs. ASML

Last updated Jun 4, 2026

ISRG (Intuitive Surgical, Inc.) and ASML (ASML Holding N.V.) are both stocks. ISRG operates in Medical Instruments & Supplies (Healthcare), while ASML operates in Semiconductor Equipment & Materials (Technology). Over the past 10 years, ISRG returned 19.13%/yr vs 34.11%/yr for ASML. At a 0.39 correlation, their price movements are largely independent.

Performance

ISRG vs. ASML - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Intuitive Surgical, Inc. (ISRG) and ASML Holding N.V. (ASML). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ISRG achieves a -28.09% return, which is significantly lower than ASML's 61.93% return. Over the past 10 years, ISRG has underperformed ASML with an annualized return of 19.13%, while ASML has yielded a comparatively higher 34.11% annualized return.

ISRG

• 1D: 1.24%
• 1M: -9.96%
• YTD: -28.09%
• 6M: -28.51%
• 1Y: -26.20%
• 3Y*: 9.27%
• 5Y*: 8.00%
• 10Y*: 19.13%

ASML

• 1D: 1.23%
• 1M: 24.54%
• YTD: 61.93%
• 6M: 51.85%
• 1Y: 132.84%
• 3Y*: 34.91%
• 5Y*: 21.59%
• 10Y*: 34.11%

*Multi-year figures are annualized to reflect compound growth (CAGR)

ISRG vs. ASML - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ISRG Intuitive Surgical, Inc.	-28.09%	8.51%	54.72%	27.14%	-26.15%	31.76%	38.39%	23.43%	31.23%	72.64%
ASML ASML Holding N.V.	61.93%	56.51%	-7.70%	39.91%	-30.49%	64.13%	66.06%	93.56%	-9.80%	56.23%

Correlation

The correlation between ISRG and ASML is 0.29, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.29
Correlation (3Y) Calculated over the trailing 3-year period	0.43
Correlation (5Y) Calculated over the trailing 5-year period	0.51
Correlation (10Y) Calculated over the trailing 10-year period	0.52
Correlation (All Time) Calculated using the full available price history since Jun 19, 2000	0.39

The correlation between ISRG and ASML shifts across timeframes, from 0.29 (1 year) to 0.52 (10 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap ISRG : $146.54B ASML : $665.86B
EPS ISRG : $8.24 ASML : $25.86
PE Ratio ISRG : 49.43 ASML : 66.77
PEG Ratio ISRG : 3.03 ASML : 4.39
PS Ratio ISRG : 13.91 ASML : 19.84
PB Ratio ISRG : 8.33 ASML : 31.97
Total Revenue (TTM) ISRG : $10.58B ASML : $33.69B
Gross Profit (TTM) ISRG : $7.02B ASML : $17.72B
EBITDA (TTM) ISRG : $3.76B ASML : $12.99B

Return for Risk

ISRG vs. ASML — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ISRG

ISRG Risk / Return Rank: 8
ISRG Sharpe Ratio Rank: 7
ISRG Sortino Ratio Rank: 8
ISRG Omega Ratio Rank: 10
ISRG Calmar Ratio Rank: 9
ISRG Martin Ratio Rank: 3

ASML

ASML Risk / Return Rank: 94
ASML Sharpe Ratio Rank: 95
ASML Sortino Ratio Rank: 93
ASML Omega Ratio Rank: 91
ASML Calmar Ratio Rank: 95
ASML Martin Ratio Rank: 95

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ISRG vs. ASML - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Intuitive Surgical, Inc. (ISRG) and ASML Holding N.V. (ASML). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ISRG	ASML	Difference
Sharpe ratio Return per unit of total volatility	-0.85	3.29	-4.15
Sortino ratio Return per unit of downside risk	-1.23	3.71	-4.94
Omega ratio Gain probability vs. loss probability	0.86	1.45	-0.60
Calmar ratio Return relative to maximum drawdown	-0.82	7.48	-8.30
Martin ratio Return relative to average drawdown	-1.65	20.18	-21.82
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ISRG vs. ASML - Sharpe Ratio Comparison

The current ISRG Sharpe Ratio is -0.85, which is lower than the ASML Sharpe Ratio of 3.29. The chart below compares the historical Sharpe Ratios of ISRG and ASML, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	ISRG	ASML	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.85	3.29	-4.15
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.24	0.52	-0.27
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.59	0.89	-0.30
Sharpe Ratio (All Time) Calculated using the full available price history	0.47	0.56	-0.08

Drawdowns

ISRG vs. ASML - Drawdown Comparison

The maximum ISRG drawdown since its inception was -82.26%, smaller than the maximum ASML drawdown of -90.00%. Use the drawdown chart below to compare losses from any high point for ISRG and ASML.

Drawdown Indicators

	ISRG	ASML	Difference
Max Drawdown Largest peak-to-trough decline	-82.26%	-90.00%	+7.74%
Max Drawdown (1Y) Largest decline over 1 year	-32.14%	-17.85%	-14.29%
Max Drawdown (3Y) Largest decline over 3 years	-34.10%	-45.38%	+11.28%
Max Drawdown (5Y) Largest decline over 5 years	-49.90%	-56.84%	+6.94%
Max Drawdown (10Y) Largest decline over 10 years	-49.90%	-56.84%	+6.94%
Current Drawdown Current decline from peak	-33.28%	0.00%	-33.28%
Average Drawdown Average peak-to-trough decline	-21.27%	-28.15%	+6.88%
Ulcer Index Depth and duration of drawdowns from previous peaks	15.91%	6.61%	+9.30%

Volatility

ISRG vs. ASML - Volatility Comparison

The current volatility for Intuitive Surgical, Inc. (ISRG) is 11.07%, while ASML Holding N.V. (ASML) has a volatility of 14.67%. This indicates that ISRG experiences smaller price fluctuations and is considered to be less risky than ASML based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ISRG	ASML	Difference
Volatility (1M) Calculated over the trailing 1-month period	11.07%	14.67%	-3.60%
Volatility (6M) Calculated over the trailing 6-month period	20.23%	32.21%	-11.98%
Volatility (1Y) Calculated over the trailing 1-year period	30.83%	40.58%	-9.75%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	33.15%	42.03%	-8.88%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	32.38%	38.50%	-6.12%

Dividends

ISRG vs. ASML - Dividend Comparison

ISRG has not paid dividends to shareholders, while ASML's dividend yield for the trailing twelve months is around 0.51%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
ASML ASML Holding N.V.	0.51%	0.97%	0.97%	0.86%	1.27%	0.50%	0.50%	1.40%	0.94%	0.64%	0.92%	0.73%
ISRG Intuitive Surgical, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Financials

ISRG vs. ASML - Profitability Comparison

The chart below illustrates the profitability comparison between Intuitive Surgical, Inc. and ASML Holding N.V. over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

ISRG - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Intuitive Surgical, Inc. reported a gross profit of 1.83B and revenue of 2.77B. Therefore, the gross margin over that period was 66.1%.

ASML - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, ASML Holding N.V. reported a gross profit of 4.65B and revenue of 8.77B. Therefore, the gross margin over that period was 53.0%.

ISRG - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Intuitive Surgical, Inc. reported an operating income of 855.30M and revenue of 2.77B, resulting in an operating margin of 30.9%.

ASML - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, ASML Holding N.V. reported an operating income of 3.16B and revenue of 8.77B, resulting in an operating margin of 36.0%.

ISRG - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Intuitive Surgical, Inc. reported a net income of 821.50M and revenue of 2.77B, resulting in a net margin of 29.7%.

ASML - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, ASML Holding N.V. reported a net income of 2.76B and revenue of 8.77B, resulting in a net margin of 31.4%.

Frequently Asked Questions

Can I hold both ISRG and ASML in my portfolio?

ISRG and ASML have a correlation of 0.29, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ISRG or ASML?

ASML has higher volatility (14.67%) compared to ISRG (11.07%). In terms of maximum drawdown, ISRG dropped -82.26% vs ASML's -90.00%.

Which has better risk-adjusted returns?

ASML currently has the higher Sharpe Ratio (3.29 vs -0.85), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.