INO vs. CRBU
INO (Inovio Pharmaceuticals, Inc.) and CRBU (Caribou Biosciences, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, INO returned -63.24%/yr vs -38.20%/yr for CRBU. Their 0.46 correlation means their historical movements had little consistent relationship.
Performance
INO vs. CRBU - Performance Comparison
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Returns By Period
In the year-to-date period, INO achieves a -61.09% return, which is significantly lower than CRBU's -8.18% return.
INO
- 1D
- 3.20%
- 1M
- -44.51%
- 6M
- -58.47%
- YTD
- -61.09%
- 1Y
- -52.66%
- 3Y*
- -51.59%
- 5Y*
- -63.24%
- 10Y*
- -40.51%
- ALL TIME*
- -22.28%
CRBU
- 1D
- -3.31%
- 1M
- -19.78%
- 6M
- 3.55%
- YTD
- -8.18%
- 1Y
- -25.13%
- 3Y*
- -41.55%
- 5Y*
- -38.20%
- 10Y*
- —
- ALL TIME*
- -39.13%
Liquidity Comparison
| Position | Avg. Volume Value (2W) | Avg. Volume Value (1M) | Avg. Volume Value (3M) |
|---|---|---|---|
| $1.81M | $3.07M | $3.70M | |
| $4.50M | $2.97M | $3.39M |
INO vs. CRBU - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | |
|---|---|---|---|---|---|---|
INO Inovio Pharmaceuticals, Inc. | -61.09% | -4.92% | -70.10% | -67.31% | -68.74% | -42.25% |
CRBU Caribou Biosciences, Inc. | -8.18% | 0.00% | -72.25% | -8.76% | -58.38% | -14.50% |
Correlation
The correlation between INO and CRBU is 0.37, which is low. Their historical price movements had little consistent relationship.
| Correlation | |
|---|---|
Correlation (1Y) Focuses on recent behavior, but can change the most. | 0.37 |
Correlation (3Y) Balances recent behavior with more history. | 0.42 |
Correlation (5Y) Shows whether the relationship held over a longer period. | 0.46 |
Correlation (All Time) Calculated using the full available price history since Jul 23, 2021 | 0.46 |
Fundamentals
INO:
$36.28M
CRBU:
$144.80M
INO:
-$48.88
CRBU:
-$1.41
INO:
0.08
CRBU:
1.37
INO:
$0.00
CRBU:
$8.81M
INO:
-$1.50M
CRBU:
$7.49M
INO:
-$22.01B
CRBU:
-$115.23M
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Return for Risk
INO vs. CRBU — Risk / Return Rank
INO
CRBU
INO vs. CRBU - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Inovio Pharmaceuticals, Inc. (INO) and Caribou Biosciences, Inc. (CRBU). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| INO | CRBU | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -0.23 | ||
| Sortino ratioReturn per unit of downside risk | -0.35 | ||
| Omega ratioGain probability vs. loss probability | 0.93 | 0.99 | -0.06 |
| Calmar ratioReturn relative to maximum drawdown | -0.68 | -0.55 | -0.13 |
| Martin ratioReturn relative to average drawdown | -1.23 | -0.89 | -0.34 |
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Drawdowns
INO vs. CRBU - Drawdown Comparison
The maximum INO drawdown since its inception was -99.97%, roughly equal to the maximum CRBU drawdown of -97.58%. Use the drawdown chart below to compare losses from any high point for INO and CRBU.
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Drawdown Indicators
| INO | CRBU | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -99.97% | -97.58% | -2.39% |
Max Drawdown (1Y)Largest decline over 1 year | -77.14% | -51.06% | -26.08% |
Max Drawdown (3Y)Largest decline over 3 years | -95.27% | -91.12% | -4.15% |
Max Drawdown (5Y)Largest decline over 5 years | -99.44% | -97.58% | -1.86% |
Max Drawdown (10Y)Largest decline over 10 years | -99.83% | — | — |
Current DrawdownCurrent decline from peak | -99.97% | -95.18% | -4.79% |
Average DrawdownAverage peak-to-trough decline | -92.38% | -79.71% | -12.67% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 42.55% | 31.64% | +10.91% |
Volatility
INO vs. CRBU - Volatility Comparison
Inovio Pharmaceuticals, Inc. (INO) has a higher volatility of 47.66% compared to Caribou Biosciences, Inc. (CRBU) at 13.75%. This indicates that INO's price experiences larger fluctuations and is considered to be riskier than CRBU based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| INO | CRBU | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 47.66% | 13.75% | +33.91% |
Volatility (6M)Calculated over the trailing 6-month period | 73.50% | 48.91% | +24.59% |
Volatility (1Y)Calculated over the trailing 1-year period | 86.75% | 74.25% | +12.50% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 87.21% | 86.14% | +1.07% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 93.96% | 86.04% | +7.92% |
Dividends
INO vs. CRBU - Dividend Comparison
Neither INO nor CRBU has paid dividends to shareholders.
Financials
INO vs. CRBU - Financials Comparison
This section allows you to compare key financial metrics between Inovio Pharmaceuticals, Inc. and Caribou Biosciences, Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
Frequently Asked Questions
INO and CRBU have a correlation of 0.37, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
INO has higher volatility (47.66%) compared to CRBU (13.75%). In terms of maximum drawdown, INO dropped -99.97% vs CRBU's -97.58%.
CRBU currently has the higher Sharpe Ratio (-0.38 vs -0.60), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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