GREK vs. SBIO

Last updated Jul 21, 2026

GREK (Global X MSCI Greece ETF) and SBIO (ALPS Medical Breakthroughs ETF) are both exchange-traded funds - GREK is a Emerging Markets Equities fund tracking the MSCI All Greece Select 25-50, while SBIO is a Health & Biotech Equities fund tracking the S-Network Medical Breakthroughs Index. Both are passively managed. Over the past 10 years, GREK returned 16.17%/yr vs 10.96%/yr for SBIO. At a 0.29 correlation, their price movements are largely independent. GREK charges 0.58%/yr vs 0.50%/yr for SBIO.

Performance

GREK vs. SBIO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Global X MSCI Greece ETF (GREK) and ALPS Medical Breakthroughs ETF (SBIO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, GREK achieves a 14.15% return, which is significantly lower than SBIO's 24.17% return. Over the past 10 years, GREK has outperformed SBIO with an annualized return of 16.17%, while SBIO has yielded a comparatively lower 10.96% annualized return.

GREK

• 1D: 0.11%
• 1M: -2.53%
• 6M: 7.43%
• YTD: 14.15%
• 1Y: 25.52%
• 3Y*: 27.97%
• 5Y*: 27.03%
• 10Y*: 16.17%
• ALL TIME*: 5.76%

SBIO

• 1D: -2.45%
• 1M: 15.41%
• 6M: 24.53%
• YTD: 24.17%
• 1Y: 93.61%
• 3Y*: 27.21%
• 5Y*: 6.86%
• 10Y*: 10.96%
• ALL TIME*: 9.19%

*Multi-year figures are annualized to reflect compound growth (CAGR)

GREK vs. SBIO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
GREK Global X MSCI Greece ETF	14.15%	76.11%	9.53%	42.72%	3.64%	6.14%	-13.89%	50.20%	-31.25%	34.80%
SBIO ALPS Medical Breakthroughs ETF	24.17%	55.07%	3.81%	8.68%	-28.08%	-17.55%	21.17%	50.30%	-11.81%	45.67%

Correlation

The correlation between GREK and SBIO is 0.28, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.28
Correlation (3Y) Calculated over the trailing 3-year period	0.29
Correlation (5Y) Calculated over the trailing 5-year period	0.33
Correlation (10Y) Calculated over the trailing 10-year period	0.31
Correlation (All Time) Calculated using the full available price history since Dec 31, 2014	0.29

GREK vs. SBIO - Sectors Allocation Comparison

Sectors	GREK	SBIO
Financial Services	48.8%	-0.0%
Utilities	14.3%	-
Industrials	12.5%	-
Consumer Cyclical	8.7%	-
Energy	6.8%	-
Communication Services	4.1%	-
Basic Materials	3.0%	-
Real Estate	1.0%	-
Consumer Defensive	1.0%	-
Healthcare	-	100.0%
Technology	-	-

Return for Risk

GREK vs. SBIO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

GREK

GREK Risk / Return Rank: 37
GREK Sharpe Ratio Rank: 39
GREK Sortino Ratio Rank: 42
GREK Omega Ratio Rank: 39
GREK Calmar Ratio Rank: 31
GREK Martin Ratio Rank: 33

SBIO

SBIO Risk / Return Rank: 95
SBIO Sharpe Ratio Rank: 96
SBIO Sortino Ratio Rank: 94
SBIO Omega Ratio Rank: 91
SBIO Calmar Ratio Rank: 97
SBIO Martin Ratio Rank: 95

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

GREK vs. SBIO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Global X MSCI Greece ETF (GREK) and ALPS Medical Breakthroughs ETF (SBIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	GREK	SBIO	Difference
Sharpe ratio: Return per unit of total volatility	1.05	3.07	-2.01
Sortino ratio: Return per unit of downside risk	1.68	3.87	-2.19
Omega ratio: Gain probability vs. loss probability	1.20	1.46	-0.26
Calmar ratio: Return relative to maximum drawdown	1.20	7.44	-6.23
Martin ratio: Return relative to average drawdown	3.69	20.36	-16.67

GREK vs. SBIO - Sharpe Ratio Comparison

The current GREK Sharpe Ratio is 1.05, which is lower than the SBIO Sharpe Ratio of 3.07. The chart below compares the historical Sharpe Ratios of GREK and SBIO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

GREK vs. SBIO - Drawdown Comparison

The maximum GREK drawdown since its inception was -79.50%, which is greater than SBIO's maximum drawdown of -63.06%. Use the drawdown chart below to compare losses from any high point for GREK and SBIO.

Drawdown Indicators

	GREK	SBIO	Difference
Max Drawdown Largest peak-to-trough decline	-79.50%	-63.06%	-16.44%
Max Drawdown (1Y) Largest decline over 1 year	-21.32%	-12.66%	-8.66%
Max Drawdown (3Y) Largest decline over 3 years	-22.63%	-42.44%	+19.81%
Max Drawdown (5Y) Largest decline over 5 years	-30.46%	-52.49%	+22.03%
Max Drawdown (10Y) Largest decline over 10 years	-57.04%	-63.06%	+6.02%
Current Drawdown Current decline from peak	-4.93%	-7.75%	+2.82%
Average Drawdown Average peak-to-trough decline	-44.97%	-28.20%	-16.77%
Ulcer Index Depth and duration of drawdowns from previous peaks	6.93%	4.61%	+2.32%

Volatility

GREK vs. SBIO - Volatility Comparison

The current volatility for Global X MSCI Greece ETF (GREK) is 5.98%, while ALPS Medical Breakthroughs ETF (SBIO) has a volatility of 11.36%. This indicates that GREK experiences smaller price fluctuations and is considered to be less risky than SBIO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	GREK	SBIO	Difference
Volatility (1M) Calculated over the trailing 1-month period	5.98%	11.36%	-5.38%
Volatility (6M) Calculated over the trailing 6-month period	21.10%	24.09%	-2.99%
Volatility (1Y) Calculated over the trailing 1-year period	24.36%	30.73%	-6.37%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	24.39%	33.90%	-9.51%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	28.85%	33.16%	-4.31%

GREK vs. SBIO - Expense Ratio Comparison

GREK has a 0.58% expense ratio, which is higher than SBIO's 0.50% expense ratio.

Dividends

GREK vs. SBIO - Dividend Comparison

GREK's dividend yield for the trailing twelve months is around 2.61%, while SBIO has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
GREK Global X MSCI Greece ETF	2.61%	3.46%	4.63%	2.61%	2.82%	2.16%	2.62%	2.25%	2.41%	2.13%	1.95%	1.52%
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%	0.00%	0.00%

Frequently Asked Questions

Can I hold both GREK and SBIO in my portfolio?

GREK and SBIO have a correlation of 0.28, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, GREK or SBIO?

SBIO has higher volatility (11.36%) compared to GREK (5.98%). In terms of maximum drawdown, GREK dropped -79.50% vs SBIO's -63.06%.

Which ETF is better, GREK or SBIO?

On 10-year performance, GREK leads with 16.17% vs 10.96% for SBIO. On fees, SBIO is cheaper at 0.50% per year. On volatility, GREK has been the lower-risk option at 5.98%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, GREK or SBIO?

Over the 10-year period, GREK has performed better with a 16.17% return vs 10.96%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, GREK or SBIO?

SBIO is cheaper with a 0.50% expense ratio, compared with 0.58% for GREK.

Which ETF pays a higher dividend yield, GREK or SBIO?

GREK has the higher dividend yield at 2.61%, compared with 0.00% for SBIO.

What is the main difference between GREK and SBIO?

GREK is categorized as Emerging Markets Equities, while SBIO is Health & Biotech Equities. GREK tracks MSCI All Greece Select 25-50, while SBIO tracks S-Network Medical Breakthroughs Index. They also come from different issuers: Global X and SS&C. Their fees differ too: 0.58% for GREK and 0.50% for SBIO.

Which has better risk-adjusted returns?

SBIO currently has the higher Sharpe Ratio (3.07 vs 1.05), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.