EXEL vs. ISRG
EXEL (Exelixis, Inc.) and ISRG (Intuitive Surgical, Inc.) are both stocks. Both are in the Healthcare sector — EXEL in Biotechnology, ISRG in Medical Instruments & Supplies. Over the past 10 years, EXEL returned 19.21%/yr vs 16.50%/yr for ISRG. Their 0.31 correlation means their historical movements had little consistent relationship.
Performance
EXEL vs. ISRG - Performance Comparison
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Returns By Period
In the year-to-date period, EXEL achieves a 20.99% return, which is significantly higher than ISRG's -37.61% return. Over the past 10 years, EXEL has outperformed ISRG with an annualized return of 19.21%, while ISRG has yielded a comparatively lower 16.50% annualized return.
EXEL
- 1D
- -5.25%
- 1M
- -1.72%
- 6M
- 28.22%
- YTD
- 20.99%
- 1Y
- 46.41%
- 3Y*
- 39.27%
- 5Y*
- 25.77%
- 10Y*
- 19.21%
- ALL TIME*
- 4.71%
ISRG
- 1D
- 0.10%
- 1M
- -12.19%
- 6M
- -29.93%
- YTD
- -37.61%
- 1Y
- -26.56%
- 3Y*
- 2.94%
- 5Y*
- 1.35%
- 10Y*
- 16.50%
- ALL TIME*
- 21.88%
Liquidity Comparison
| Position | Avg. Volume Value (2W) | Avg. Volume Value (1M) | Avg. Volume Value (3M) |
|---|---|---|---|
EXEL Exelixis, Inc. | $119.34M | $130.32M | $139.06M |
| $1.43B | $1.49B | $1.19B |
EXEL vs. ISRG - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
EXEL Exelixis, Inc. | 20.99% | 31.62% | 38.81% | 49.56% | -12.25% | -8.92% | 13.90% | -10.42% | -35.30% | 103.89% |
ISRG Intuitive Surgical, Inc. | -37.61% | 8.51% | 54.72% | 27.14% | -26.15% | 31.76% | 38.39% | 23.43% | 31.23% | 72.64% |
Correlation
The correlation between EXEL and ISRG is 0.25, which is low. Their historical price movements had little consistent relationship.
| Correlation | |
|---|---|
Correlation (1Y) Focuses on recent behavior, but can change the most. | 0.25 |
Correlation (3Y) Balances recent behavior with more history. | 0.26 |
Correlation (5Y) Shows whether the relationship held over a longer period. | 0.31 |
Correlation (10Y) Provides a long-term view across more market conditions. | 0.31 |
Correlation (All Time) Calculated using the full available price history since Jun 16, 2000 | 0.31 |
Fundamentals
EXEL:
$13.33B
ISRG:
$124.82B
EXEL:
$3.02
ISRG:
$8.72
EXEL:
17.56
ISRG:
40.54
EXEL:
0.31
ISRG:
2.48
EXEL:
6.16
ISRG:
11.53
EXEL:
7.32
ISRG:
6.92
EXEL:
$2.38B
ISRG:
$11.03B
EXEL:
$1.70B
ISRG:
$7.36B
EXEL:
$991.79M
ISRG:
$4.18B
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Return for Risk
EXEL vs. ISRG — Risk / Return Rank
EXEL
ISRG
EXEL vs. ISRG - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Exelixis, Inc. (EXEL) and Intuitive Surgical, Inc. (ISRG). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| EXEL | ISRG | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +2.08 | ||
| Sortino ratioReturn per unit of downside risk | +2.88 | ||
| Omega ratioGain probability vs. loss probability | 1.25 | 0.88 | +0.38 |
| Calmar ratioReturn relative to maximum drawdown | 2.83 | -0.61 | +3.44 |
| Martin ratioReturn relative to average drawdown | 8.84 | -1.40 | +10.24 |
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Drawdowns
EXEL vs. ISRG - Drawdown Comparison
The maximum EXEL drawdown since its inception was -97.38%, which is greater than ISRG's maximum drawdown of -82.26%. Use the drawdown chart below to compare losses from any high point for EXEL and ISRG.
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Drawdown Indicators
| EXEL | ISRG | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -97.38% | -82.26% | -15.12% |
Max Drawdown (1Y)Largest decline over 1 year | -16.47% | -44.00% | +27.53% |
Max Drawdown (3Y)Largest decline over 3 years | -25.34% | -45.61% | +20.27% |
Max Drawdown (5Y)Largest decline over 5 years | -35.41% | -49.90% | +14.49% |
Max Drawdown (10Y)Largest decline over 10 years | -57.20% | -49.90% | -7.30% |
Current DrawdownCurrent decline from peak | -7.13% | -42.12% | +34.99% |
Average DrawdownAverage peak-to-trough decline | -70.68% | -21.36% | -49.32% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 5.27% | 19.01% | -13.74% |
Volatility
EXEL vs. ISRG - Volatility Comparison
The current volatility for Exelixis, Inc. (EXEL) is 8.73%, while Intuitive Surgical, Inc. (ISRG) has a volatility of 20.49%. This indicates that EXEL experiences smaller price fluctuations and is considered to be less risky than ISRG based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| EXEL | ISRG | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 8.73% | 20.49% | -11.76% |
Volatility (6M)Calculated over the trailing 6-month period | 24.34% | 28.02% | -3.68% |
Volatility (1Y)Calculated over the trailing 1-year period | 35.10% | 35.93% | -0.83% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 35.68% | 34.29% | +1.39% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 44.47% | 32.94% | +11.53% |
Dividends
EXEL vs. ISRG - Dividend Comparison
Neither EXEL nor ISRG has paid dividends to shareholders.
Financials
EXEL vs. ISRG - Financials Comparison
This section allows you to compare key financial metrics between Exelixis, Inc. and Intuitive Surgical, Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
EXEL vs. ISRG - Profitability Comparison
EXEL - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Aug 2026, Exelixis, Inc. reported a gross profit of 0.00 and revenue of 610.81M. Therefore, the gross margin over that period was 0.0%.
ISRG - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Aug 2026, Intuitive Surgical, Inc. reported a gross profit of 1.96B and revenue of 2.89B. Therefore, the gross margin over that period was 67.8%.
EXEL - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Aug 2026, Exelixis, Inc. reported an operating income of 251.34M and revenue of 610.81M, resulting in an operating margin of 41.2%.
ISRG - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Aug 2026, Intuitive Surgical, Inc. reported an operating income of 971.90M and revenue of 2.89B, resulting in an operating margin of 33.6%.
EXEL - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Aug 2026, Exelixis, Inc. reported a net income of 210.47M and revenue of 610.81M, resulting in a net margin of 34.5%.
ISRG - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Aug 2026, Intuitive Surgical, Inc. reported a net income of 818.10M and revenue of 2.89B, resulting in a net margin of 28.3%.
Frequently Asked Questions
EXEL and ISRG have a correlation of 0.25, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
ISRG has higher volatility (20.49%) compared to EXEL (8.73%). In terms of maximum drawdown, EXEL dropped -97.38% vs ISRG's -82.26%.
EXEL currently has the higher Sharpe Ratio (1.33 vs -0.75), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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