DTIL vs. MREO

Last updated Jun 4, 2026

DTIL (Precision BioSciences, Inc.) and MREO (Mereo BioPharma Group plc) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, DTIL returned -55.07%/yr vs -37.84%/yr for MREO. At a 0.22 correlation, their price movements are largely independent.

Performance

DTIL vs. MREO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Precision BioSciences, Inc. (DTIL) and Mereo BioPharma Group plc (MREO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, DTIL achieves a 45.19% return, which is significantly higher than MREO's -19.80% return.

DTIL

• 1D: -4.43%
• 1M: -20.84%
• YTD: 45.19%
• 6M: 19.37%
• 1Y: 17.28%
• 3Y*: -35.49%
• 5Y*: -55.07%
• 10Y*: —

MREO

• 1D: -1.53%
• 1M: 16.41%
• YTD: -19.80%
• 6M: -82.95%
• 1Y: -87.39%
• 3Y*: -31.94%
• 5Y*: -37.84%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

DTIL vs. MREO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
DTIL Precision BioSciences, Inc.	45.19%	9.19%	-65.21%	-69.33%	-83.92%	-11.27%	-39.96%	8.69%
MREO Mereo BioPharma Group plc	-19.80%	-88.09%	51.52%	208.00%	-53.12%	-55.31%	9.15%	-49.54%

Correlation

The correlation between DTIL and MREO is 0.27, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.27
Correlation (3Y) Calculated over the trailing 3-year period	0.22
Correlation (5Y) Calculated over the trailing 5-year period	0.27
Correlation (All Time) Calculated using the full available price history since Apr 25, 2019	0.22

Fundamentals

Market Cap DTIL : $148.79M MREO : $53.59M
EPS DTIL : -$2.95 MREO : -$0.22
PS Ratio DTIL : 2.02 MREO : 106.89
PB Ratio DTIL : 1.96 MREO : 1.57
Total Revenue (TTM) DTIL : $45.07M MREO : $500.00K
Gross Profit (TTM) DTIL : $32.19M MREO : $366.00K
EBITDA (TTM) DTIL : -$30.02M MREO : -$39.61M

Return for Risk

DTIL vs. MREO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

DTIL

DTIL Risk / Return Rank: 49
DTIL Sharpe Ratio Rank: 50
DTIL Sortino Ratio Rank: 51
DTIL Omega Ratio Rank: 48
DTIL Calmar Ratio Rank: 48
DTIL Martin Ratio Rank: 47

MREO

MREO Risk / Return Rank: 14
MREO Sharpe Ratio Rank: 13
MREO Sortino Ratio Rank: 24
MREO Omega Ratio Rank: 20
MREO Calmar Ratio Rank: 4
MREO Martin Ratio Rank: 8

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

DTIL vs. MREO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Precision BioSciences, Inc. (DTIL) and Mereo BioPharma Group plc (MREO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	DTIL	MREO	Difference
Sharpe ratio: Return per unit of total volatility	0.25	-0.65	+0.90
Sortino ratio: Return per unit of downside risk	0.85	-0.30	+1.15
Omega ratio: Gain probability vs. loss probability	1.10	0.94	+0.16
Calmar ratio: Return relative to maximum drawdown	0.30	-0.95	+1.25
Martin ratio: Return relative to average drawdown	0.56	-1.39	+1.96
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

DTIL vs. MREO - Sharpe Ratio Comparison

The current DTIL Sharpe Ratio is 0.25, which is higher than the MREO Sharpe Ratio of -0.65. The chart below compares the historical Sharpe Ratios of DTIL and MREO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	DTIL	MREO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.25	-0.65	+0.90
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.70	-0.38	-0.32
Sharpe Ratio (All Time) Calculated using the full available price history	-0.55	-0.30	-0.25

Drawdowns

DTIL vs. MREO - Drawdown Comparison

The maximum DTIL drawdown since its inception was -99.39%, roughly equal to the maximum MREO drawdown of -96.35%. Use the drawdown chart below to compare losses from any high point for DTIL and MREO.

Drawdown Indicators

	DTIL	MREO	Difference
Max Drawdown Largest peak-to-trough decline	-99.39%	-96.35%	-3.04%
Max Drawdown (1Y) Largest decline over 1 year	-58.54%	-91.93%	+33.39%
Max Drawdown (3Y) Largest decline over 3 years	-85.40%	-95.13%	+9.73%
Max Drawdown (5Y) Largest decline over 5 years	-99.16%	-95.13%	-4.03%
Current Drawdown Current decline from peak	-98.98%	-94.86%	-4.12%
Average Drawdown Average peak-to-trough decline	-77.65%	-65.90%	-11.75%
Ulcer Index Depth and duration of drawdowns from previous peaks	30.78%	62.66%	-31.88%

Volatility

DTIL vs. MREO - Volatility Comparison

The current volatility for Precision BioSciences, Inc. (DTIL) is 20.95%, while Mereo BioPharma Group plc (MREO) has a volatility of 36.10%. This indicates that DTIL experiences smaller price fluctuations and is considered to be less risky than MREO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	DTIL	MREO	Difference
Volatility (1M) Calculated over the trailing 1-month period	20.95%	36.10%	-15.15%
Volatility (6M) Calculated over the trailing 6-month period	49.88%	224.43%	-174.55%
Volatility (1Y) Calculated over the trailing 1-year period	68.81%	134.18%	-65.37%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	79.38%	100.56%	-21.18%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	84.87%	113.66%	-28.79%

Dividends

DTIL vs. MREO - Dividend Comparison

Neither DTIL nor MREO has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both DTIL and MREO in my portfolio?

DTIL and MREO have a correlation of 0.27, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, DTIL or MREO?

MREO has higher volatility (36.10%) compared to DTIL (20.95%). In terms of maximum drawdown, DTIL dropped -99.39% vs MREO's -96.35%.

Which has better risk-adjusted returns?

DTIL currently has the higher Sharpe Ratio (0.25 vs -0.65), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.