CRDL vs. TLSA

Last updated Jun 4, 2026

CRDL (Cardiol Therapeutics Inc Class A) and TLSA (Tiziana Life Sciences PLC) are both stocks. Both are in the Healthcare sector — CRDL in Drug Manufacturers - Specialty & Generic, TLSA in Biotechnology. Over the past 5 years, CRDL returned -16.24%/yr vs -12.87%/yr for TLSA. At a 0.11 correlation, their price movements are largely independent.

Performance

CRDL vs. TLSA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Cardiol Therapeutics Inc Class A (CRDL) and Tiziana Life Sciences PLC (TLSA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CRDL achieves a 17.43% return, which is significantly higher than TLSA's -20.81% return.

CRDL

• 1D: -2.61%
• 1M: -15.79%
• YTD: 17.43%
• 6M: 18.62%
• 1Y: -14.50%
• 3Y*: 18.79%
• 5Y*: -16.24%
• 10Y*: —

TLSA

• 1D: -13.24%
• 1M: -15.11%
• YTD: -20.81%
• 6M: -30.18%
• 1Y: -16.90%
• 3Y*: 4.64%
• 5Y*: -12.87%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

CRDL vs. TLSA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
CRDL Cardiol Therapeutics Inc Class A	17.43%	-25.48%	51.80%	65.33%	-72.43%	-15.14%	-38.35%	-5.49%
TLSA Tiziana Life Sciences PLC	-20.81%	114.02%	24.32%	-6.43%	-37.66%	-52.48%	86.96%	-18.67%

Correlation

The correlation between CRDL and TLSA is 0.26, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.26
Correlation (3Y) Calculated over the trailing 3-year period	0.13
Correlation (5Y) Calculated over the trailing 5-year period	0.12
Correlation (All Time) Calculated using the full available price history since Jan 16, 2019	0.11

The correlation between CRDL and TLSA shifts across timeframes, from 0.11 (all time) to 0.26 (1 year), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap CRDL : $112.29M TLSA : $70.17M
EPS CRDL : -$0.38 TLSA : -$0.59
PB Ratio CRDL : 6.28 TLSA : 1.35K
Total Revenue (TTM) CRDL : $0.00 TLSA : $0.00
Gross Profit (TTM) CRDL : -$25.95K TLSA : -$421.00K
EBITDA (TTM) CRDL : -$34.00M TLSA : -$42.26M

Return for Risk

CRDL vs. TLSA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CRDL

CRDL Risk / Return Rank: 32
CRDL Sharpe Ratio Rank: 32
CRDL Sortino Ratio Rank: 35
CRDL Omega Ratio Rank: 34
CRDL Calmar Ratio Rank: 29
CRDL Martin Ratio Rank: 31

TLSA

TLSA Risk / Return Rank: 33
TLSA Sharpe Ratio Rank: 32
TLSA Sortino Ratio Rank: 36
TLSA Omega Ratio Rank: 35
TLSA Calmar Ratio Rank: 31
TLSA Martin Ratio Rank: 32

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CRDL vs. TLSA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Cardiol Therapeutics Inc Class A (CRDL) and Tiziana Life Sciences PLC (TLSA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	CRDL	TLSA	Difference
Sharpe ratio: Return per unit of total volatility	-0.21	-0.21	+0.01
Sortino ratio: Return per unit of downside risk	0.19	0.25	-0.06
Omega ratio: Gain probability vs. loss probability	1.02	1.03	0.00
Calmar ratio: Return relative to maximum drawdown	-0.37	-0.31	-0.05
Martin ratio: Return relative to average drawdown	-0.54	-0.50	-0.04
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

CRDL vs. TLSA - Sharpe Ratio Comparison

The current CRDL Sharpe Ratio is -0.21, which is comparable to the TLSA Sharpe Ratio of -0.21. The chart below compares the historical Sharpe Ratios of CRDL and TLSA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	CRDL	TLSA	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.21	-0.21	+0.01
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.19	-0.14	-0.05
Sharpe Ratio (All Time) Calculated using the full available price history	-0.17	-0.04	-0.13

Drawdowns

CRDL vs. TLSA - Drawdown Comparison

The maximum CRDL drawdown since its inception was -92.71%, roughly equal to the maximum TLSA drawdown of -94.03%. Use the drawdown chart below to compare losses from any high point for CRDL and TLSA.

Drawdown Indicators

	CRDL	TLSA	Difference
Max Drawdown Largest peak-to-trough decline	-92.71%	-94.03%	+1.32%
Max Drawdown (1Y) Largest decline over 1 year	-39.87%	-54.00%	+14.13%
Max Drawdown (3Y) Largest decline over 3 years	-72.73%	-55.66%	-17.07%
Max Drawdown (5Y) Largest decline over 5 years	-90.72%	-84.02%	-6.70%
Current Drawdown Current decline from peak	-81.91%	-83.12%	+1.21%
Average Drawdown Average peak-to-trough decline	-68.97%	-70.29%	+1.32%
Ulcer Index Depth and duration of drawdowns from previous peaks	27.03%	34.09%	-7.06%

Volatility

CRDL vs. TLSA - Volatility Comparison

The current volatility for Cardiol Therapeutics Inc Class A (CRDL) is 10.42%, while Tiziana Life Sciences PLC (TLSA) has a volatility of 26.73%. This indicates that CRDL experiences smaller price fluctuations and is considered to be less risky than TLSA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CRDL	TLSA	Difference
Volatility (1M) Calculated over the trailing 1-month period	10.42%	26.73%	-16.31%
Volatility (6M) Calculated over the trailing 6-month period	41.95%	54.90%	-12.95%
Volatility (1Y) Calculated over the trailing 1-year period	70.39%	79.45%	-9.06%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	87.04%	92.71%	-5.67%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	87.07%	112.60%	-25.53%

Dividends

CRDL vs. TLSA - Dividend Comparison

Neither CRDL nor TLSA has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both CRDL and TLSA in my portfolio?

CRDL and TLSA have a correlation of 0.26, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CRDL or TLSA?

TLSA has higher volatility (26.73%) compared to CRDL (10.42%). In terms of maximum drawdown, CRDL dropped -92.71% vs TLSA's -94.03%.

Which has better risk-adjusted returns?

CRDL currently has the higher Sharpe Ratio (-0.21 vs -0.21), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.