CLPT vs. TWST
CLPT (ClearPoint Neuro, Inc.) and TWST (Twist Bioscience Corporation) are both stocks. Both are in the Healthcare sector — CLPT in Medical Devices, TWST in Diagnostics & Research. Over the past 5 years, CLPT returned -2.27%/yr vs -6.65%/yr for TWST. At a 0.40 correlation, their price movements are largely independent.
Performance
CLPT vs. TWST - Performance Comparison
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Returns By Period
In the year-to-date period, CLPT achieves a 24.71% return, which is significantly lower than TWST's 168.51% return.
CLPT
- 1D
- -4.00%
- 1M
- 49.13%
- YTD
- 24.71%
- 6M
- 16.77%
- 1Y
- 51.51%
- 3Y*
- 37.52%
- 5Y*
- -2.27%
- 10Y*
- —
TWST
- 1D
- -2.73%
- 1M
- 40.61%
- YTD
- 168.51%
- 6M
- 142.93%
- 1Y
- 145.87%
- 3Y*
- 70.18%
- 5Y*
- -6.65%
- 10Y*
- —
CLPT vs. TWST - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | |
|---|---|---|---|---|---|---|---|
CLPT ClearPoint Neuro, Inc. | 24.71% | -11.05% | 126.51% | -19.83% | -24.51% | -29.39% | 200.95% |
TWST Twist Bioscience Corporation | 168.51% | -31.74% | 26.07% | 54.81% | -69.23% | -45.23% | 363.25% |
Correlation
The correlation between CLPT and TWST is 0.35, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.35 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.42 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.43 |
Correlation (All Time) Calculated using the full available price history since Feb 12, 2020 | 0.40 |
Fundamentals
CLPT:
$504.07M
TWST:
$5.26B
CLPT:
-$1.01
TWST:
-$1.33
CLPT:
12.03
TWST:
12.71
CLPT:
26.75
TWST:
11.55
CLPT:
$40.61M
TWST:
$409.48M
CLPT:
$25.32M
TWST:
$213.23M
CLPT:
-$25.05M
TWST:
-$58.23M
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Return for Risk
CLPT vs. TWST — Risk / Return Rank
CLPT
TWST
CLPT vs. TWST - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for ClearPoint Neuro, Inc. (CLPT) and Twist Bioscience Corporation (TWST). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| CLPT | TWST | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -1.70 | ||
| Sortino ratioReturn per unit of downside risk | -1.15 | ||
| Omega ratioGain probability vs. loss probability | 1.20 | 1.31 | -0.12 |
| Calmar ratioReturn relative to maximum drawdown | 0.73 | 3.84 | -3.11 |
| Martin ratioReturn relative to average drawdown | 1.13 | 8.14 | -7.01 |
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Drawdowns
CLPT vs. TWST - Drawdown Comparison
The maximum CLPT drawdown since its inception was -84.62%, smaller than the maximum TWST drawdown of -94.48%. Use the drawdown chart below to compare losses from any high point for CLPT and TWST.
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Drawdown Indicators
| CLPT | TWST | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -84.62% | -94.48% | +9.86% |
Max Drawdown (1Y)Largest decline over 1 year | -70.74% | -38.24% | -32.50% |
Max Drawdown (3Y)Largest decline over 3 years | -70.74% | -58.97% | -11.77% |
Max Drawdown (5Y)Largest decline over 5 years | -79.96% | -91.54% | +11.58% |
Current DrawdownCurrent decline from peak | -42.36% | -59.05% | +16.69% |
Average DrawdownAverage peak-to-trough decline | -53.50% | -58.15% | +4.65% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 45.63% | 17.99% | +27.64% |
Volatility
CLPT vs. TWST - Volatility Comparison
ClearPoint Neuro, Inc. (CLPT) has a higher volatility of 29.74% compared to Twist Bioscience Corporation (TWST) at 19.89%. This indicates that CLPT's price experiences larger fluctuations and is considered to be riskier than TWST based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| CLPT | TWST | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 29.74% | 19.89% | +9.85% |
Volatility (6M)Calculated over the trailing 6-month period | 65.67% | 48.60% | +17.07% |
Volatility (1Y)Calculated over the trailing 1-year period | 104.26% | 66.98% | +37.28% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 78.80% | 75.93% | +2.87% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 80.77% | 78.40% | +2.37% |
Dividends
CLPT vs. TWST - Dividend Comparison
Neither CLPT nor TWST has paid dividends to shareholders.
Financials
CLPT vs. TWST - Financials Comparison
This section allows you to compare key financial metrics between ClearPoint Neuro, Inc. and Twist Bioscience Corporation. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
CLPT vs. TWST - Profitability Comparison
CLPT - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, ClearPoint Neuro, Inc. reported a gross profit of 7.76M and revenue of 12.13M. Therefore, the gross margin over that period was 64.0%.
TWST - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Twist Bioscience Corporation reported a gross profit of 57.12M and revenue of 110.72M. Therefore, the gross margin over that period was 51.6%.
CLPT - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, ClearPoint Neuro, Inc. reported an operating income of -8.48M and revenue of 12.13M, resulting in an operating margin of -69.9%.
TWST - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Twist Bioscience Corporation reported an operating income of -45.86M and revenue of 110.72M, resulting in an operating margin of -41.4%.
CLPT - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, ClearPoint Neuro, Inc. reported a net income of -9.55M and revenue of 12.13M, resulting in a net margin of -78.8%.
TWST - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Twist Bioscience Corporation reported a net income of -44.02M and revenue of 110.72M, resulting in a net margin of -39.8%.
Frequently Asked Questions
CLPT and TWST have a correlation of 0.35, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
CLPT has higher volatility (29.74%) compared to TWST (19.89%). In terms of maximum drawdown, CLPT dropped -84.62% vs TWST's -94.48%.
TWST currently has the higher Sharpe Ratio (2.20 vs 0.50), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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