CANC vs. GERM

Last updated Jun 24, 2026

CANC (Tema Oncology ETF) and GERM (Amplify Treatments, Testing and Advancements ETF) are both Health & Biotech Equities funds. CANC is actively managed, while GERM is passively managed. Over the past year, CANC returned 56.88% vs 0.00% for GERM. CANC charges 0.75%/yr vs 0.68%/yr for GERM.

Performance

CANC vs. GERM - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Tema Oncology ETF (CANC) and Amplify Treatments, Testing and Advancements ETF (GERM). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

CANC

• 1D: 1.64%
• 1M: 1.56%
• YTD: 11.49%
• 6M: 9.19%
• 1Y: 56.88%
• 3Y*: 132.65%
• 5Y*: —
• 10Y*: —

GERM

• 1D: 0.00%
• 1M: 0.00%
• YTD: 0.00%
• 6M: 0.00%
• 1Y: 0.00%
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

CANC vs. GERM - Yearly Performance Comparison

	2026 (YTD)	2025	2024
CANC Tema Oncology ETF	11.49%	42.92%	-12.72%
GERM Amplify Treatments, Testing and Advancements ETF	0.00%	0.00%	0.00%

CANC vs. GERM - Sectors Allocation Comparison

Sectors	CANC	GERM
Healthcare	100.0%	99.3%
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	0.4%
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

CANC vs. GERM — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CANC

CANC Risk / Return Rank: 85
CANC Sharpe Ratio Rank: 85
CANC Sortino Ratio Rank: 86
CANC Omega Ratio Rank: 74
CANC Calmar Ratio Rank: 93
CANC Martin Ratio Rank: 85

GERM

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CANC vs. GERM - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Tema Oncology ETF (CANC) and Amplify Treatments, Testing and Advancements ETF (GERM). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	CANC	GERM	Difference
Sharpe ratio: Return per unit of total volatility	2.52	—	—
Sortino ratio: Return per unit of downside risk	3.54	—	—
Omega ratio: Gain probability vs. loss probability	1.40	—	—
Calmar ratio: Return relative to maximum drawdown	6.15	—	—
Martin ratio: Return relative to average drawdown	16.71	—	—

Drawdowns

CANC vs. GERM - Drawdown Comparison

The maximum CANC drawdown since its inception was -97.53%, which is greater than GERM's maximum drawdown of 0.00%. Use the drawdown chart below to compare losses from any high point for CANC and GERM.

Drawdown Indicators

	CANC	GERM	Difference
Max Drawdown Largest peak-to-trough decline	-97.53%	0.00%	-97.53%
Max Drawdown (1Y) Largest decline over 1 year	-9.30%	0.00%	-9.30%
Max Drawdown (3Y) Largest decline over 3 years	-30.27%	—	—
Current Drawdown Current decline from peak	-53.78%	0.00%	-53.78%
Average Drawdown Average peak-to-trough decline	-72.94%	0.00%	-72.94%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.41%	0.00%	+3.41%

Volatility

CANC vs. GERM - Volatility Comparison

Tema Oncology ETF (CANC) has a higher volatility of 6.60% compared to Amplify Treatments, Testing and Advancements ETF (GERM) at 0.00%. This indicates that CANC's price experiences larger fluctuations and is considered to be riskier than GERM based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CANC	GERM	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.60%	0.00%	+6.60%
Volatility (6M) Calculated over the trailing 6-month period	16.94%	0.00%	+16.94%
Volatility (1Y) Calculated over the trailing 1-year period	22.72%	0.00%	+22.72%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	278.65%	0.00%	+278.65%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	278.65%	0.00%	+278.65%

CANC vs. GERM - Expense Ratio Comparison

CANC has a 0.75% expense ratio, which is higher than GERM's 0.68% expense ratio.

Dividends

CANC vs. GERM - Dividend Comparison

CANC's dividend yield for the trailing twelve months is around 0.05%, while GERM has not paid dividends to shareholders.

Position	TTM	2025	2024	2023
CANC Tema Oncology ETF	0.05%	0.06%	3.00%	0.56%
GERM Amplify Treatments, Testing and Advancements ETF	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Which is riskier, CANC or GERM?

CANC has higher volatility (6.60%) compared to GERM (0.00%). In terms of maximum drawdown, CANC dropped -97.53% vs GERM's 0.00%.

Which ETF is better, CANC or GERM?

On 1-year performance, CANC leads with 56.88% vs 0.00% for GERM. On fees, GERM is cheaper at 0.68% per year. On volatility, GERM has been the lower-risk option at 0.00%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, CANC or GERM?

Over the 1-year period, CANC has performed better with a 56.88% return vs 0.00%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, CANC or GERM?

GERM is cheaper with a 0.68% expense ratio, compared with 0.75% for CANC.

Which ETF pays a higher dividend yield, CANC or GERM?

CANC has the higher dividend yield at 0.05%, compared with 0.00% for GERM.

What is the main difference between CANC and GERM?

They also come from different issuers: Tema and Amplify. Their fees differ too: 0.75% for CANC and 0.68% for GERM.