CANC vs. GERM

Last updated Jun 4, 2026

CANC (Tema Oncology ETF) and GERM (Amplify Treatments, Testing and Advancements ETF) are both Health & Biotech Equities funds. CANC is actively managed, while GERM is passively managed. Over the past year, CANC returned 47.37% vs 0.00% for GERM. CANC charges 0.75%/yr vs 0.68%/yr for GERM.

Performance

CANC vs. GERM - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Tema Oncology ETF (CANC) and Amplify Treatments, Testing and Advancements ETF (GERM). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

CANC

• 1D: 0.08%
• 1M: -3.73%
• YTD: 4.82%
• 6M: 3.86%
• 1Y: 47.37%
• 3Y*: 107.76%
• 5Y*: —
• 10Y*: —

GERM

• 1D: 0.00%
• 1M: 0.00%
• YTD: 0.00%
• 6M: 0.00%
• 1Y: 0.00%
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

CANC vs. GERM - Yearly Performance Comparison

	2026 (YTD)	2025	2024
CANC Tema Oncology ETF	4.82%	42.92%	-12.26%
GERM Amplify Treatments, Testing and Advancements ETF	0.00%	0.00%	0.00%

CANC vs. GERM - Sectors Allocation Comparison

Sectors	CANC	GERM
Healthcare	100.0%	99.3%
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	0.4%
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

CANC vs. GERM — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CANC

CANC Risk / Return Rank: 69
CANC Sharpe Ratio Rank: 61
CANC Sortino Ratio Rank: 64
CANC Omega Ratio Rank: 54
CANC Calmar Ratio Rank: 90
CANC Martin Ratio Rank: 77

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CANC vs. GERM - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Tema Oncology ETF (CANC) and Amplify Treatments, Testing and Advancements ETF (GERM). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	CANC	GERM	Difference
Sharpe ratio: Return per unit of total volatility	2.06	—	—
Sortino ratio: Return per unit of downside risk	2.96	—	—
Omega ratio: Gain probability vs. loss probability	1.34	—	—
Calmar ratio: Return relative to maximum drawdown	5.49	—	—
Martin ratio: Return relative to average drawdown	14.62	—	—
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

Sharpe Ratios by Period

	CANC	GERM	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.06	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.04	—	—

Drawdowns

CANC vs. GERM - Drawdown Comparison

The maximum CANC drawdown since its inception was -97.53%, which is greater than GERM's maximum drawdown of 0.00%. Use the drawdown chart below to compare losses from any high point for CANC and GERM.

Drawdown Indicators

	CANC	GERM	Difference
Max Drawdown Largest peak-to-trough decline	-97.53%	0.00%	-97.53%
Max Drawdown (1Y) Largest decline over 1 year	-8.67%	0.00%	-8.67%
Max Drawdown (3Y) Largest decline over 3 years	-30.27%	—	—
Current Drawdown Current decline from peak	-56.55%	0.00%	-56.55%
Average Drawdown Average peak-to-trough decline	-73.19%	0.00%	-73.19%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.25%	0.00%	+3.25%

Volatility

CANC vs. GERM - Volatility Comparison

Tema Oncology ETF (CANC) has a higher volatility of 6.26% compared to Amplify Treatments, Testing and Advancements ETF (GERM) at 0.00%. This indicates that CANC's price experiences larger fluctuations and is considered to be riskier than GERM based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CANC	GERM	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.26%	0.00%	+6.26%
Volatility (6M) Calculated over the trailing 6-month period	16.69%	0.00%	+16.69%
Volatility (1Y) Calculated over the trailing 1-year period	23.11%	0.00%	+23.11%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	280.27%	0.00%	+280.27%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	280.27%	0.00%	+280.27%

CANC vs. GERM - Expense Ratio Comparison

CANC has a 0.75% expense ratio, which is higher than GERM's 0.68% expense ratio.

Dividends

CANC vs. GERM - Dividend Comparison

CANC's dividend yield for the trailing twelve months is around 0.05%, while GERM has not paid dividends to shareholders.

Position	TTM	2025	2024	2023
CANC Tema Oncology ETF	0.05%	0.06%	3.00%	0.56%
GERM Amplify Treatments, Testing and Advancements ETF	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Which is riskier, CANC or GERM?

CANC has higher volatility (6.26%) compared to GERM (0.00%). In terms of maximum drawdown, CANC dropped -97.53% vs GERM's 0.00%.

Which ETF is better, CANC or GERM?

On 1-year performance, CANC leads with 47.37% vs 0.00% for GERM. On fees, GERM is cheaper at 0.68% per year. On volatility, GERM has been the lower-risk option at 0.00%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, CANC or GERM?

Over the 1-year period, CANC has performed better with a 47.37% return vs 0.00%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, CANC or GERM?

GERM is cheaper with a 0.68% expense ratio, compared with 0.75% for CANC.

Which ETF pays a higher dividend yield, CANC or GERM?

CANC has the higher dividend yield at 0.05%, compared with 0.00% for GERM.

What is the main difference between CANC and GERM?

They also come from different issuers: Tema and Amplify. Their fees differ too: 0.75% for CANC and 0.68% for GERM.