CABA vs. QQQI

Last updated Apr 1, 2026

Compare and contrast key facts about Cabaletta Bio, Inc. (CABA) and NEOS Nasdaq-100 High Income ETF (QQQI).

QQQI is an actively managed fund by Neos. It was launched on Jan 29, 2024.

Performance

CABA vs. QQQI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Cabaletta Bio, Inc. (CABA) and NEOS Nasdaq-100 High Income ETF (QQQI). The values are adjusted to include any dividend payments, if applicable.

CABA vs. QQQI - Yearly Performance Comparison

	2026 (YTD)	2025	2024
CABA Cabaletta Bio, Inc.	22.83%	-3.52%	-89.27%
QQQI NEOS Nasdaq-100 High Income ETF	-4.41%	18.62%	19.83%

Returns By Period

In the year-to-date period, CABA achieves a 22.83% return, which is significantly higher than QQQI's -4.41% return.

CABA

• 1D: 8.91%
• 1M: -18.98%
• YTD: 22.83%
• 6M: 14.96%
• 1Y: 94.22%
• 3Y*: -31.23%
• 5Y*: -25.51%
• 10Y*: —

QQQI

• 1D: 3.26%
• 1M: -4.11%
• YTD: -4.41%
• 6M: -1.61%
• 1Y: 20.87%
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

CABA vs. QQQI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CABA

CABA Risk / Return Rank: 73
CABA Sharpe Ratio Rank: 70
CABA Sortino Ratio Rank: 80
CABA Omega Ratio Rank: 75
CABA Calmar Ratio Rank: 72
CABA Martin Ratio Rank: 66

QQQI

QQQI Risk / Return Rank: 72
QQQI Sharpe Ratio Rank: 64
QQQI Sortino Ratio Rank: 69
QQQI Omega Ratio Rank: 71
QQQI Calmar Ratio Rank: 75
QQQI Martin Ratio Rank: 81

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CABA vs. QQQI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Cabaletta Bio, Inc. (CABA) and NEOS Nasdaq-100 High Income ETF (QQQI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	CABA	QQQI	Difference
Sharpe ratio Return per unit of total volatility	0.82	1.06	-0.24
Sortino ratio Return per unit of downside risk	2.05	1.65	+0.40
Omega ratio Gain probability vs. loss probability	1.24	1.25	-0.01
Calmar ratio Return relative to maximum drawdown	1.59	1.82	-0.23
Martin ratio Return relative to average drawdown	2.77	8.28	-5.51
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

CABA vs. QQQI - Sharpe Ratio Comparison

The current CABA Sharpe Ratio is 0.82, which is comparable to the QQQI Sharpe Ratio of 1.06. The chart below compares the historical Sharpe Ratios of CABA and QQQI, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	CABA	QQQI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.82	1.06	-0.24
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.23	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.17	0.88	-1.04

Correlation

The correlation between CABA and QQQI is 0.32, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

CABA vs. QQQI - Dividend Comparison

CABA has not paid dividends to shareholders, while QQQI's dividend yield for the trailing twelve months is around 15.05%.

	TTM	2025	2024
CABA Cabaletta Bio, Inc.	0.00%	0.00%	0.00%
QQQI NEOS Nasdaq-100 High Income ETF	15.05%	13.82%	12.85%

Drawdowns

CABA vs. QQQI - Drawdown Comparison

The maximum CABA drawdown since its inception was -96.63%, which is greater than QQQI's maximum drawdown of -20.00%. Use the drawdown chart below to compare losses from any high point for CABA and QQQI.

Drawdown Indicators

	CABA	QQQI	Difference
Max Drawdown Largest peak-to-trough decline	-96.63%	-20.00%	-76.63%
Max Drawdown (1Y) Largest decline over 1 year	-46.37%	-11.46%	-34.91%
Max Drawdown (5Y) Largest decline over 5 years	-95.90%	—	—
Current Drawdown Current decline from peak	-89.40%	-6.66%	-82.74%
Average Drawdown Average peak-to-trough decline	-58.92%	-2.31%	-56.61%
Ulcer Index Depth and duration of drawdowns from previous peaks	26.53%	2.52%	+24.01%

Volatility

CABA vs. QQQI - Volatility Comparison

Cabaletta Bio, Inc. (CABA) has a higher volatility of 20.56% compared to NEOS Nasdaq-100 High Income ETF (QQQI) at 6.11%. This indicates that CABA's price experiences larger fluctuations and is considered to be riskier than QQQI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CABA	QQQI	Difference
Volatility (1M) Calculated over the trailing 1-month period	20.56%	6.11%	+14.45%
Volatility (6M) Calculated over the trailing 6-month period	78.26%	11.18%	+67.08%
Volatility (1Y) Calculated over the trailing 1-year period	115.96%	19.70%	+96.26%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	112.81%	17.49%	+95.32%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	110.00%	17.49%	+92.51%