CABA vs. SANA

Last updated Jun 4, 2026

CABA (Cabaletta Bio, Inc.) and SANA (Sana Biotechnology, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, CABA returned -18.46%/yr vs -31.74%/yr for SANA. At a 0.35 correlation, their price movements are largely independent.

Performance

CABA vs. SANA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Cabaletta Bio, Inc. (CABA) and Sana Biotechnology, Inc. (SANA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CABA achieves a 63.47% return, which is significantly higher than SANA's -23.34% return.

CABA

• 1D: -2.72%
• 1M: -6.53%
• YTD: 63.47%
• 6M: 43.20%
• 1Y: 64.22%
• 3Y*: -31.52%
• 5Y*: -18.46%
• 10Y*: —

SANA

• 1D: -3.70%
• 1M: -8.50%
• YTD: -23.34%
• 6M: -30.20%
• 1Y: 33.33%
• 3Y*: -21.42%
• 5Y*: -31.74%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

CABA vs. SANA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
CABA Cabaletta Bio, Inc.	63.47%	-3.52%	-90.00%	145.41%	144.06%	-70.69%
SANA Sana Biotechnology, Inc.	-23.34%	149.69%	-60.05%	3.29%	-74.48%	-55.90%

Correlation

The correlation between CABA and SANA is 0.34, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.34
Correlation (3Y) Calculated over the trailing 3-year period	0.36
Correlation (5Y) Calculated over the trailing 5-year period	0.35
Correlation (All Time) Calculated using the full available price history since Feb 5, 2021	0.35

Fundamentals

Market Cap CABA : $401.05M SANA : $863.79M
EPS CABA : -$1.85 SANA : -$0.94
PB Ratio CABA : 3.88 SANA : 7.24
Total Revenue (TTM) CABA : $0.00 SANA : $0.00
Gross Profit (TTM) CABA : $148.00K SANA : $0.00
EBITDA (TTM) CABA : -$181.04M SANA : -$193.23M

Return for Risk

CABA vs. SANA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CABA

CABA Risk / Return Rank: 65
CABA Sharpe Ratio Rank: 60
CABA Sortino Ratio Rank: 70
CABA Omega Ratio Rank: 67
CABA Calmar Ratio Rank: 67
CABA Martin Ratio Rank: 62

SANA

SANA Risk / Return Rank: 55
SANA Sharpe Ratio Rank: 53
SANA Sortino Ratio Rank: 59
SANA Omega Ratio Rank: 57
SANA Calmar Ratio Rank: 55
SANA Martin Ratio Rank: 52

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CABA vs. SANA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Cabaletta Bio, Inc. (CABA) and Sana Biotechnology, Inc. (SANA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	CABA	SANA	Difference
Sharpe ratio: Return per unit of total volatility	0.59	0.35	+0.24
Sortino ratio: Return per unit of downside risk	1.76	1.24	+0.52
Omega ratio: Gain probability vs. loss probability	1.21	1.15	+0.06
Calmar ratio: Return relative to maximum drawdown	1.39	0.61	+0.78
Martin ratio: Return relative to average drawdown	2.42	1.04	+1.38
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

CABA vs. SANA - Sharpe Ratio Comparison

The current CABA Sharpe Ratio is 0.59, which is higher than the SANA Sharpe Ratio of 0.35. The chart below compares the historical Sharpe Ratios of CABA and SANA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	CABA	SANA	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.59	0.35	+0.24
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.16	-0.27	+0.11
Sharpe Ratio (All Time) Calculated using the full available price history	-0.13	-0.31	+0.18

Drawdowns

CABA vs. SANA - Drawdown Comparison

The maximum CABA drawdown since its inception was -96.63%, roughly equal to the maximum SANA drawdown of -96.92%. Use the drawdown chart below to compare losses from any high point for CABA and SANA.

Drawdown Indicators

	CABA	SANA	Difference
Max Drawdown Largest peak-to-trough decline	-96.63%	-96.92%	+0.29%
Max Drawdown (1Y) Largest decline over 1 year	-46.37%	-54.73%	+8.36%
Max Drawdown (3Y) Largest decline over 3 years	-95.90%	-88.11%	-7.79%
Max Drawdown (5Y) Largest decline over 5 years	-95.90%	-94.82%	-1.08%
Current Drawdown Current decline from peak	-85.89%	-92.83%	+6.94%
Average Drawdown Average peak-to-trough decline	-59.66%	-81.47%	+21.81%
Ulcer Index Depth and duration of drawdowns from previous peaks	26.65%	32.14%	-5.49%

Volatility

CABA vs. SANA - Volatility Comparison

Cabaletta Bio, Inc. (CABA) has a higher volatility of 21.67% compared to Sana Biotechnology, Inc. (SANA) at 14.31%. This indicates that CABA's price experiences larger fluctuations and is considered to be riskier than SANA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CABA	SANA	Difference
Volatility (1M) Calculated over the trailing 1-month period	21.67%	14.31%	+7.36%
Volatility (6M) Calculated over the trailing 6-month period	61.03%	52.42%	+8.61%
Volatility (1Y) Calculated over the trailing 1-year period	108.82%	95.88%	+12.94%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	113.62%	118.43%	-4.81%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	109.69%	117.26%	-7.57%

Dividends

CABA vs. SANA - Dividend Comparison

Neither CABA nor SANA has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both CABA and SANA in my portfolio?

CABA and SANA have a correlation of 0.34, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CABA or SANA?

CABA has higher volatility (21.67%) compared to SANA (14.31%). In terms of maximum drawdown, CABA dropped -96.63% vs SANA's -96.92%.

Which has better risk-adjusted returns?

CABA currently has the higher Sharpe Ratio (0.59 vs 0.35), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.