CABA vs. SANA

Last updated Apr 2, 2026

Compare and contrast key facts about Cabaletta Bio, Inc. (CABA) and Sana Biotechnology, Inc. (SANA).

Performance

CABA vs. SANA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Cabaletta Bio, Inc. (CABA) and Sana Biotechnology, Inc. (SANA). The values are adjusted to include any dividend payments, if applicable.

CABA vs. SANA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
CABA Cabaletta Bio, Inc.	22.37%	-3.52%	-90.00%	145.41%	144.06%	-70.69%
SANA Sana Biotechnology, Inc.	-25.06%	149.69%	-60.05%	3.29%	-74.48%	-55.90%

Fundamentals

EPS CABA : -$3.07 SANA : -$0.97
Total Revenue (TTM) CABA : $0.00 SANA : $0.00
Gross Profit (TTM) CABA : $0.00 SANA : $0.00
EBITDA (TTM) CABA : -$172.24M SANA : -$250.32M

Returns By Period

In the year-to-date period, CABA achieves a 22.37% return, which is significantly higher than SANA's -25.06% return.

CABA

• 1D: -0.37%
• 1M: -18.79%
• YTD: 22.37%
• 6M: 16.02%
• 1Y: 129.06%
• 3Y*: -31.31%
• 5Y*: -25.57%
• 10Y*: —

SANA

• 1D: 5.90%
• 1M: -26.51%
• YTD: -25.06%
• 6M: -17.57%
• 1Y: 103.33%
• 3Y*: -2.29%
• 5Y*: -37.51%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

CABA vs. SANA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CABA

CABA Risk / Return Rank: 77
CABA Sharpe Ratio Rank: 76
CABA Sortino Ratio Rank: 84
CABA Omega Ratio Rank: 78
CABA Calmar Ratio Rank: 76
CABA Martin Ratio Rank: 70

SANA

SANA Risk / Return Rank: 72
SANA Sharpe Ratio Rank: 73
SANA Sortino Ratio Rank: 77
SANA Omega Ratio Rank: 72
SANA Calmar Ratio Rank: 70
SANA Martin Ratio Rank: 67

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CABA vs. SANA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Cabaletta Bio, Inc. (CABA) and Sana Biotechnology, Inc. (SANA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	CABA	SANA	Difference
Sharpe ratio Return per unit of total volatility	1.14	0.98	+0.15
Sortino ratio Return per unit of downside risk	2.36	1.97	+0.39
Omega ratio Gain probability vs. loss probability	1.27	1.24	+0.04
Calmar ratio Return relative to maximum drawdown	2.02	1.49	+0.53
Martin ratio Return relative to average drawdown	3.56	3.07	+0.49
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

CABA vs. SANA - Sharpe Ratio Comparison

The current CABA Sharpe Ratio is 1.14, which is comparable to the SANA Sharpe Ratio of 0.98. The chart below compares the historical Sharpe Ratios of CABA and SANA, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	CABA	SANA	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.14	0.98	+0.15
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.23	-0.32	+0.09
Sharpe Ratio (All Time) Calculated using the full available price history	-0.17	-0.32	+0.15

Correlation

The correlation between CABA and SANA is 0.35, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

CABA vs. SANA - Dividend Comparison

Neither CABA nor SANA has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

CABA vs. SANA - Drawdown Comparison

The maximum CABA drawdown since its inception was -96.63%, roughly equal to the maximum SANA drawdown of -96.92%. Use the drawdown chart below to compare losses from any high point for CABA and SANA.

Drawdown Indicators

	CABA	SANA	Difference
Max Drawdown Largest peak-to-trough decline	-96.63%	-96.92%	+0.29%
Max Drawdown (1Y) Largest decline over 1 year	-46.37%	-54.73%	+8.36%
Max Drawdown (5Y) Largest decline over 5 years	-95.90%	-95.83%	-0.07%
Current Drawdown Current decline from peak	-89.44%	-92.99%	+3.55%
Average Drawdown Average peak-to-trough decline	-58.94%	-81.10%	+22.16%
Ulcer Index Depth and duration of drawdowns from previous peaks	26.27%	26.57%	-0.30%

Volatility

CABA vs. SANA - Volatility Comparison

The current volatility for Cabaletta Bio, Inc. (CABA) is 20.56%, while Sana Biotechnology, Inc. (SANA) has a volatility of 24.65%. This indicates that CABA experiences smaller price fluctuations and is considered to be less risky than SANA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CABA	SANA	Difference
Volatility (1M) Calculated over the trailing 1-month period	20.56%	24.65%	-4.09%
Volatility (6M) Calculated over the trailing 6-month period	78.24%	67.60%	+10.64%
Volatility (1Y) Calculated over the trailing 1-year period	115.42%	106.47%	+8.95%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	112.79%	118.85%	-6.06%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	109.97%	118.78%	-8.81%

Financials