AXSM vs. ANAB

Last updated Jun 9, 2026

AXSM (Axsome Therapeutics, Inc.) and ANAB (AnaptysBio, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, AXSM returned 29.93%/yr vs 26.26%/yr for ANAB. At a 0.28 correlation, their price movements are largely independent.

Performance

AXSM vs. ANAB - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Axsome Therapeutics, Inc. (AXSM) and AnaptysBio, Inc. (ANAB). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, AXSM achieves a 28.75% return, which is significantly lower than ANAB's 58.91% return.

AXSM

• 1D: 1.21%
• 1M: 8.17%
• YTD: 28.75%
• 6M: 59.35%
• 1Y: 110.12%
• 3Y*: 47.19%
• 5Y*: 29.93%
• 10Y*: 39.88%

ANAB

• 1D: 1.97%
• 1M: -25.92%
• YTD: 58.91%
• 6M: 73.08%
• 1Y: 225.06%
• 3Y*: 60.31%
• 5Y*: 26.26%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

AXSM vs. ANAB - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
AXSM Axsome Therapeutics, Inc.	28.75%	115.86%	6.31%	3.19%	104.16%	-53.63%	-21.18%	3,565.25%	-49.64%	15.46%
ANAB AnaptysBio, Inc.	58.91%	266.16%	-38.19%	-30.88%	-10.82%	61.63%	32.31%	-74.53%	-36.67%	492.47%

Correlation

The correlation between AXSM and ANAB is 0.36, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.36
Correlation (3Y) Calculated over the trailing 3-year period	0.29
Correlation (5Y) Calculated over the trailing 5-year period	0.30
Correlation (All Time) Calculated using the full available price history since Jan 27, 2017	0.28

Fundamentals

Market Cap AXSM : $12.04B ANAB : $1.47B
EPS AXSM : -$3.74 ANAB : -$0.91
PS Ratio AXSM : 16.71 ANAB : 6.51
PB Ratio AXSM : 220.54 ANAB : 115.60
Total Revenue (TTM) AXSM : $708.24M ANAB : $232.39M
Gross Profit (TTM) AXSM : $655.82M ANAB : $245.59M
EBITDA (TTM) AXSM : -$172.72M ANAB : $52.72M

Return for Risk

AXSM vs. ANAB — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

AXSM

AXSM Risk / Return Rank: 94
AXSM Sharpe Ratio Rank: 94
AXSM Sortino Ratio Rank: 95
AXSM Omega Ratio Rank: 93
AXSM Calmar Ratio Rank: 94
AXSM Martin Ratio Rank: 94

ANAB

ANAB Risk / Return Rank: 95
ANAB Sharpe Ratio Rank: 96
ANAB Sortino Ratio Rank: 94
ANAB Omega Ratio Rank: 93
ANAB Calmar Ratio Rank: 96
ANAB Martin Ratio Rank: 96

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

AXSM vs. ANAB - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Axsome Therapeutics, Inc. (AXSM) and AnaptysBio, Inc. (ANAB). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	AXSM	ANAB	Difference
Sharpe ratio: Return per unit of total volatility	2.65	3.29	-0.64
Sortino ratio: Return per unit of downside risk	4.01	3.69	+0.32
Omega ratio: Gain probability vs. loss probability	1.47	1.49	-0.02
Calmar ratio: Return relative to maximum drawdown	5.99	8.05	-2.06
Martin ratio: Return relative to average drawdown	17.16	20.07	-2.91
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

AXSM vs. ANAB - Sharpe Ratio Comparison

The current AXSM Sharpe Ratio is 2.65, which is comparable to the ANAB Sharpe Ratio of 3.29. The chart below compares the historical Sharpe Ratios of AXSM and ANAB, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	AXSM	ANAB	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.65	3.29	-0.64
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.43	0.40	+0.02
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.44	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.40	0.23	+0.17

Drawdowns

AXSM vs. ANAB - Drawdown Comparison

The maximum AXSM drawdown since its inception was -86.65%, smaller than the maximum ANAB drawdown of -92.08%. Use the drawdown chart below to compare losses from any high point for AXSM and ANAB.

Drawdown Indicators

	AXSM	ANAB	Difference
Max Drawdown Largest peak-to-trough decline	-86.65%	-92.08%	+5.43%
Max Drawdown (1Y) Largest decline over 1 year	-18.50%	-28.15%	+9.65%
Max Drawdown (3Y) Largest decline over 3 years	-36.45%	-69.32%	+32.87%
Max Drawdown (5Y) Largest decline over 5 years	-72.91%	-69.32%	-3.59%
Max Drawdown (10Y) Largest decline over 10 years	-81.26%	—	—
Current Drawdown Current decline from peak	-0.35%	-40.07%	+39.72%
Average Drawdown Average peak-to-trough decline	-39.55%	-64.71%	+25.16%
Ulcer Index Depth and duration of drawdowns from previous peaks	6.56%	11.27%	-4.71%

Volatility

AXSM vs. ANAB - Volatility Comparison

The current volatility for Axsome Therapeutics, Inc. (AXSM) is 9.83%, while AnaptysBio, Inc. (ANAB) has a volatility of 12.10%. This indicates that AXSM experiences smaller price fluctuations and is considered to be less risky than ANAB based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	AXSM	ANAB	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.83%	12.10%	-2.27%
Volatility (6M) Calculated over the trailing 6-month period	32.98%	46.22%	-13.24%
Volatility (1Y) Calculated over the trailing 1-year period	41.79%	68.91%	-27.12%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	70.31%	65.30%	+5.01%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	90.68%	75.47%	+15.21%

Dividends

AXSM vs. ANAB - Dividend Comparison

Neither AXSM nor ANAB has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both AXSM and ANAB in my portfolio?

AXSM and ANAB have a correlation of 0.36, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, AXSM or ANAB?

ANAB has higher volatility (12.10%) compared to AXSM (9.83%). In terms of maximum drawdown, AXSM dropped -86.65% vs ANAB's -92.08%.

Which has better risk-adjusted returns?

ANAB currently has the higher Sharpe Ratio (3.29 vs 2.65), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.