Defiance Autism Impact ETF (ASD) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with ASD. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to ASD
ASD charges 0.79% annually. There are 52 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | ASD vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.87B | Dec 1998 | ASD vs XLV | |
| Vanguard Health Care ETF | 0.09% | 20.40B | Jan 2004 | ASD vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 933.15M | Nov 2025 | ASD vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | ASD vs GSKH |
Best Risk-Adjusted Alternatives to ASD
Among 56 ETFs in the Health & Biotech Equities category with risk / return rank data, the top risk-adjusted alternatives shown here go as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 50.05M | Dec 2014 | ASD vs BBC | |
| ALPS Medical Breakthroughs ETF | 95 | 206.77M | Dec 2014 | ASD vs SBIO | |
| First Trust Nasdaq Pharmaceuticals ETF | 94 | 55.96M | Sep 2016 | ASD vs FTXH | |
| SPDR S&P Biotech ETF | 94 | 10.21B | Feb 2006 | ASD vs XBI | |
| iShares U.S. Pharmaceuticals ETF | 94 | 1.44B | May 2006 | ASD vs IHE |
Top Performing ASD Alternatives (YTD)
Among 63 ETFs in the Health & Biotech Equities category with YTD return data, the top-performing alternatives shown here go as high as 40.48%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| AdvisorShares Psychedelics ETF | 40.48% | 46.53M | Sep 2021 | ASD vs PSIL | |
| ARK Genomic Revolution Multi-Sector ETF | 32.14% | 1.73B | Oct 2014 | ASD vs ARKG | |
| Roundhill UNH WeeklyPay ETF | 31.26% | 7.08M | Dec 2025 | ASD vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 28.98% | 50.05M | Dec 2014 | ASD vs BBC | |
| SPDR S&P Health Care Services ETF | 25.92% | 208.33M | Sep 2011 | ASD vs XHS |
Lowest Volatility Alternatives to ASD
ASD has 16.76% 1-year volatility. There are 18 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | ASD vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | ASD vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.64% | 10.10M | Jun 2007 | ASD vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 11.05% | 18.19M | Jul 2025 | ASD vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.43% | 982.35K | Apr 2026 | ASD vs MHIP |
Lowest Drawdown Alternatives to ASD
Among 57 ETFs in the Health & Biotech Equities category with 1-year drawdown data, the lowest-drawdown alternatives shown here go as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | ASD vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.32% | 10.10M | Jun 2007 | ASD vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 55.96M | Sep 2016 | ASD vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 75.38M | Jun 2021 | ASD vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.44B | May 2006 | ASD vs IHE |
Other ETFs from Defiance
The 10 most viewed Defiance ETFs shown here include QTUM, QQQY, MSTX and span 10 categories. AUM among these funds goes as high as $5B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Defiance Quantum ETF | Technology Equities | 69 | 29.22% | 5.32B | Sep 2018 | ASD vs QTUM | |
| Defiance Nasdaq 100 Enhanced Options Income ETF | Nasdaq-100, Options Trading, Dividend | 51 | 12.87% | 184.23M | Sep 2023 | ASD vs QQQY | |
| Defiance Daily Target 2X Long MSTR ETF | Leveraged Equities | 2 | -76.49% | 149.54M | Aug 2024 | ASD vs MSTX | |
| Defiance AI & Power Infrastructure ETF | Building & Construction, Technology Equities | — | 32.91% | 895.41M | Jul 2025 | ASD vs AIPO | |
| Defiance Large Cap ex-Mag 7 ETF | Large Cap Blend Equities | 68 | 11.25% | 178.34M | Oct 2024 | ASD vs XMAG | |
| Defiance Nasdaq 100 Income Target ETF | Nasdaq-100, Derivative Income | 42 | 12.39% | 44.63M | Jun 2024 | ASD vs QQQT | |
| Defiance Drone and Modern Warfare ETF | Aerospace & Defense | — | -2.72% | 130.11M | Sep 2025 | ASD vs JEDI | |
| Defiance R2000 Weekly Distribution ETF | Options Trading | 39 | 13.63% | 97.48M | Oct 2023 | ASD vs IWMY | |
| Defiance S&P 500 Income Target ETF | Derivative Income, S&P 500 | 60 | 8.57% | 152.07M | Mar 2024 | ASD vs SPYT | |
| Defiance Oil Enhanced Options Income ETF | Derivative Income | 42 | 48.30% | 64.93M | May 2024 | ASD vs USOY |
Often Compared With ASD
Investors most often compare ASD with IDNA, AGNG, IBRN. These 4 comparison targets span 3 categories, based on PortfoliosLab usage data.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| iShares Genomics Immunology and Healthcare ETF Gen... | Health & Biotech Equities | 86 | 23.70% | 193.84M | Jun 2019 | ASD vs IDNA | |
| Global X Aging Population ETF | Health & Biotech Equities | 35 | 1.85% | 86.24M | May 2016 | ASD vs AGNG | |
| iShares Neuroscience and Healthcare ETF | Health & Biotech Equities | 92 | 14.64% | 5.68M | Aug 2022 | ASD vs IBRN | |
| Defiance Leveraged Long Income MSTR ETF | Derivative Income, Leveraged Equities | 2 | -70.90% | 12.79M | May 2025 | ASD vs MST |
Compare ASD with Any Fund or Stock
Compare ASD with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair ASD with funds that move differently
Defiance Autism Impact ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to ASD.
Explore ASD Diversifiers