ZYME vs. PVLA
ZYME (Zymeworks Inc.) and PVLA (Palvella Therapeutics, Inc) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past year, ZYME returned 91.50% vs 426.53% for PVLA. At a 0.30 correlation, their price movements are largely independent.
Performance
ZYME vs. PVLA - Performance Comparison
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Returns By Period
In the year-to-date period, ZYME achieves a -9.30% return, which is significantly lower than PVLA's 13.38% return.
ZYME
- 1D
- 2.67%
- 1M
- -6.76%
- YTD
- -9.30%
- 6M
- -10.86%
- 1Y
- 91.50%
- 3Y*
- 43.33%
- 5Y*
- -8.24%
- 10Y*
- —
PVLA
- 1D
- -0.13%
- 1M
- 4.11%
- YTD
- 13.38%
- 6M
- 18.36%
- 1Y
- 426.53%
- 3Y*
- —
- 5Y*
- —
- 10Y*
- —
ZYME vs. PVLA - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | |
|---|---|---|---|
ZYME Zymeworks Inc. | -9.30% | 79.85% | 16.38% |
PVLA Palvella Therapeutics, Inc | 13.38% | 772.25% | -8.27% |
Correlation
The correlation between ZYME and PVLA is 0.34, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.34 |
Correlation (All Time) Calculated using the full available price history since Dec 16, 2024 | 0.30 |
Fundamentals
ZYME:
$1.78B
PVLA:
$1.34B
ZYME:
-$583.41
PVLA:
-$3.75
ZYME:
0.01
PVLA:
47.72
ZYME:
$78.86M
PVLA:
$0.00
ZYME:
$77.16M
PVLA:
$0.00
ZYME:
-$47.18B
PVLA:
-$14.75M
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Return for Risk
ZYME vs. PVLA — Risk / Return Rank
ZYME
PVLA
ZYME vs. PVLA - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Zymeworks Inc. (ZYME) and Palvella Therapeutics, Inc (PVLA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| ZYME | PVLA | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -3.58 | ||
| Sortino ratioReturn per unit of downside risk | -1.78 | ||
| Omega ratioGain probability vs. loss probability | 1.33 | 1.54 | -0.21 |
| Calmar ratioReturn relative to maximum drawdown | 4.33 | 13.82 | -9.49 |
| Martin ratioReturn relative to average drawdown | 9.21 | 31.14 | -21.94 |
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Drawdowns
ZYME vs. PVLA - Drawdown Comparison
The maximum ZYME drawdown since its inception was -91.81%, which is greater than PVLA's maximum drawdown of -31.48%. Use the drawdown chart below to compare losses from any high point for ZYME and PVLA.
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Drawdown Indicators
| ZYME | PVLA | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -91.81% | -31.48% | -60.33% |
Max Drawdown (1Y)Largest decline over 1 year | -21.25% | -31.11% | +9.86% |
Max Drawdown (3Y)Largest decline over 3 years | -45.75% | — | — |
Max Drawdown (5Y)Largest decline over 5 years | -87.53% | — | — |
Current DrawdownCurrent decline from peak | -57.97% | -19.99% | -37.98% |
Average DrawdownAverage peak-to-trough decline | -52.54% | -11.16% | -41.38% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 9.97% | 13.79% | -3.82% |
Volatility
ZYME vs. PVLA - Volatility Comparison
The current volatility for Zymeworks Inc. (ZYME) is 10.12%, while Palvella Therapeutics, Inc (PVLA) has a volatility of 19.68%. This indicates that ZYME experiences smaller price fluctuations and is considered to be less risky than PVLA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| ZYME | PVLA | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 10.12% | 19.68% | -9.56% |
Volatility (6M)Calculated over the trailing 6-month period | 29.45% | 61.91% | -32.46% |
Volatility (1Y)Calculated over the trailing 1-year period | 52.91% | 80.85% | -27.94% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 61.85% | 82.11% | -20.26% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 61.45% | 82.11% | -20.66% |
Dividends
ZYME vs. PVLA - Dividend Comparison
Neither ZYME nor PVLA has paid dividends to shareholders.
Financials
ZYME vs. PVLA - Financials Comparison
This section allows you to compare key financial metrics between Zymeworks Inc. and Palvella Therapeutics, Inc. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
Frequently Asked Questions
ZYME and PVLA have a correlation of 0.34, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
PVLA has higher volatility (19.68%) compared to ZYME (10.12%). In terms of maximum drawdown, ZYME dropped -91.81% vs PVLA's -31.48%.
PVLA currently has the higher Sharpe Ratio (5.32 vs 1.74), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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