XBI vs. MSTZ

Last updated Jun 26, 2026

XBI (SPDR S&P Biotech ETF) and MSTZ (T-REX 2X Inverse MSTR Daily Target ETF) are both exchange-traded funds - XBI is a Health & Biotech Equities fund tracking the S&P Biotechnology Select Industry Index, while MSTZ is a Inverse Equities fund actively managed by REX. XBI is passively managed, while MSTZ is actively managed. Over the past year, XBI returned 82.88% vs 279.21% for MSTZ. At a correlation of -0.30, they often move in opposite directions. XBI charges 0.35%/yr vs 1.05%/yr for MSTZ.

Performance

XBI vs. MSTZ - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in SPDR S&P Biotech ETF (XBI) and T-REX 2X Inverse MSTR Daily Target ETF (MSTZ). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, XBI achieves a 24.45% return, which is significantly higher than MSTZ's 1.05% return.

XBI

• 1D: 1.26%
• 1M: 13.79%
• YTD: 24.45%
• 6M: 20.14%
• 1Y: 82.88%
• 3Y*: 22.41%
• 5Y*: 1.92%
• 10Y*: 11.96%

MSTZ

• 1D: 19.27%
• 1M: 186.45%
• YTD: 1.05%
• 6M: 9.89%
• 1Y: 279.21%
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

XBI vs. MSTZ - Yearly Performance Comparison

	2026 (YTD)	2025	2024
XBI SPDR S&P Biotech ETF	24.45%	35.89%	-10.77%
MSTZ T-REX 2X Inverse MSTR Daily Target ETF	1.05%	-38.95%	-94.43%

Correlation

The correlation between XBI and MSTZ is -0.30, meaning they tend to move in opposite directions. This is especially valuable for risk management - when one declines, the other has historically tended to hold steady or rise.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	-0.30
Correlation (All Time) Calculated using the full available price history since Sep 18, 2024	-0.30

Return for Risk

XBI vs. MSTZ — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

XBI

XBI Risk / Return Rank: 94
XBI Sharpe Ratio Rank: 95
XBI Sortino Ratio Rank: 93
XBI Omega Ratio Rank: 89
XBI Calmar Ratio Rank: 97
XBI Martin Ratio Rank: 95

MSTZ

MSTZ Risk / Return Rank: 62
MSTZ Sharpe Ratio Rank: 69
MSTZ Sortino Ratio Rank: 60
MSTZ Omega Ratio Rank: 59
MSTZ Calmar Ratio Rank: 74
MSTZ Martin Ratio Rank: 45

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

XBI vs. MSTZ - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for SPDR S&P Biotech ETF (XBI) and T-REX 2X Inverse MSTR Daily Target ETF (MSTZ). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	XBI	MSTZ	Difference
Sharpe ratio: Return per unit of total volatility	3.15	1.93	+1.22
Sortino ratio: Return per unit of downside risk	4.01	2.48	+1.53
Omega ratio: Gain probability vs. loss probability	1.48	1.32	+0.16
Calmar ratio: Return relative to maximum drawdown	8.57	3.31	+5.26
Martin ratio: Return relative to average drawdown	25.32	6.57	+18.75

XBI vs. MSTZ - Sharpe Ratio Comparison

The current XBI Sharpe Ratio is 3.15, which is higher than the MSTZ Sharpe Ratio of 1.93. The chart below compares the historical Sharpe Ratios of XBI and MSTZ, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

XBI vs. MSTZ - Drawdown Comparison

The maximum XBI drawdown since its inception was -63.89%, smaller than the maximum MSTZ drawdown of -99.38%. Use the drawdown chart below to compare losses from any high point for XBI and MSTZ.

Drawdown Indicators

	XBI	MSTZ	Difference
Max Drawdown Largest peak-to-trough decline	-63.89%	-99.38%	+35.49%
Max Drawdown (1Y) Largest decline over 1 year	-9.72%	-84.89%	+75.17%
Max Drawdown (3Y) Largest decline over 3 years	-32.99%	—	—
Max Drawdown (5Y) Largest decline over 5 years	-54.71%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-63.89%	—	—
Current Drawdown Current decline from peak	-12.30%	-96.56%	+84.26%
Average Drawdown Average peak-to-trough decline	-20.93%	-94.46%	+73.53%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.28%	42.70%	-39.42%

Volatility

XBI vs. MSTZ - Volatility Comparison

The current volatility for SPDR S&P Biotech ETF (XBI) is 9.94%, while T-REX 2X Inverse MSTR Daily Target ETF (MSTZ) has a volatility of 46.08%. This indicates that XBI experiences smaller price fluctuations and is considered to be less risky than MSTZ based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	XBI	MSTZ	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.94%	46.08%	-36.14%
Volatility (6M) Calculated over the trailing 6-month period	21.13%	129.73%	-108.60%
Volatility (1Y) Calculated over the trailing 1-year period	26.48%	145.84%	-119.36%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	32.30%	170.65%	-138.35%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	32.00%	170.65%	-138.65%

XBI vs. MSTZ - Expense Ratio Comparison

XBI has a 0.35% expense ratio, which is lower than MSTZ's 1.05% expense ratio.

Dividends

XBI vs. MSTZ - Dividend Comparison

XBI's dividend yield for the trailing twelve months is around 0.38%, while MSTZ has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
MSTZ T-REX 2X Inverse MSTR Daily Target ETF	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
XBI SPDR S&P Biotech ETF	0.38%	0.37%	0.15%	0.02%	0.00%	0.04%	0.20%	0.00%	0.28%	0.24%	0.26%	0.61%

Frequently Asked Questions

Can I hold both XBI and MSTZ in my portfolio?

XBI and MSTZ have a correlation of -0.30, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, XBI or MSTZ?

MSTZ has higher volatility (46.08%) compared to XBI (9.94%). In terms of maximum drawdown, XBI dropped -63.89% vs MSTZ's -99.38%.

Which ETF is better, XBI or MSTZ?

On 1-year performance, MSTZ leads with 279.21% vs 82.88% for XBI. On fees, XBI is cheaper at 0.35% per year. On volatility, XBI has been the lower-risk option at 9.94%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, XBI or MSTZ?

Over the 1-year period, MSTZ has performed better with a 279.21% return vs 82.88%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, XBI or MSTZ?

XBI is cheaper with a 0.35% expense ratio, compared with 1.05% for MSTZ.

Which ETF pays a higher dividend yield, XBI or MSTZ?

XBI has the higher dividend yield at 0.38%, compared with 0.00% for MSTZ.

What is the main difference between XBI and MSTZ?

XBI is categorized as Health & Biotech Equities, while MSTZ is Inverse Equities. They also come from different issuers: State Street and REX. Their fees differ too: 0.35% for XBI and 1.05% for MSTZ.

Which has better risk-adjusted returns?

XBI currently has the higher Sharpe Ratio (3.15 vs 1.93), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.