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SDGR vs. IBB
Performance
Return for Risk
Drawdowns
Volatility
Dividends

SDGR vs. IBB

Last updated Jun 4, 2026

SDGR (Schrodinger, Inc.) is a stock, while IBB (iShares Nasdaq Biotechnology ETF) is Health & Biotech Equities fund tracking the NASDAQ Biotechnology Index. Over the past 5 years, SDGR returned -26.96%/yr vs 2.10%/yr for IBB. A 0.57 correlation means they provide meaningful diversification when combined.

Performance

SDGR vs. IBB - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Schrodinger, Inc. (SDGR) and iShares Nasdaq Biotechnology ETF (IBB). The values are adjusted to include any dividend payments, if applicable.

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Returns By Period

In the year-to-date period, SDGR achieves a -16.50% return, which is significantly lower than IBB's -0.68% return.

SDGR

1D
-0.07%
1M
15.74%
YTD
-16.50%
6M
-15.84%
1Y
-34.80%
3Y*
-25.18%
5Y*
-26.96%
10Y*
—

IBB

1D
1.97%
1M
-1.56%
YTD
-0.68%
6M
-2.57%
1Y
34.50%
3Y*
9.40%
5Y*
2.10%
10Y*
6.23%
*Multi-year figures are annualized to reflect compound growth (CAGR)

SDGR vs. IBB - Yearly Performance Comparison

2026 (YTD)202520242023202220212020
SDGR
Schrodinger, Inc.		-16.50%-7.31%-46.12%91.55%-46.34%-56.01%176.47%
IBB
iShares Nasdaq Biotechnology ETF		-0.68%27.98%-2.41%3.76%-13.69%0.95%24.00%

Correlation

The correlation between SDGR and IBB is 0.44, which is low. Their price movements are largely independent, making them effective diversification partners.

Correlation
Correlation (1Y)
Calculated over the trailing 1-year period

0.44

Correlation (3Y)
Calculated over the trailing 3-year period

0.54

Correlation (5Y)
Calculated over the trailing 5-year period

0.61

Correlation (All Time)
Calculated using the full available price history since Feb 7, 2020

0.57

The correlation between SDGR and IBB shifts across timeframes, from 0.44 (1 year) to 0.61 (5 years), reflecting how their relationship changes across market environments.

Compare stocks, funds, or ETFs

Search for stocks, ETFs, and funds for a quick comparison or use the comparison tool for more options.

Schrodinger, Inc.

iShares Nasdaq Biotechnology ETF

Often compared with SDGR:
SDGR vs. VKTXSDGR vs. ROIVSDGR vs. XDWT.DESDGR vs. CATSDGR vs. COSTSDGR vs. QQQSDGR vs. VOO
Often compared with IBB:
IBB vs. XBIIBB vs. ARKGIBB vs. XLVIBB vs. IBBQIBB vs. BBHIBB vs. SPYIBB vs. FBIOX

Return for Risk

SDGR vs. IBB — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.
SDGR
SDGR Risk / Return Rank: 1717
Overall Rank
SDGR Sharpe Ratio Rank: 1313
Sharpe Ratio Rank
SDGR Sortino Ratio Rank: 1515
Sortino Ratio Rank
SDGR Omega Ratio Rank: 1616
Omega Ratio Rank
SDGR Calmar Ratio Rank: 1919
Calmar Ratio Rank
SDGR Martin Ratio Rank: 2323
Martin Ratio Rank
IBB
IBB Risk / Return Rank: 5656
Overall Rank
IBB Sharpe Ratio Rank: 5050
Sharpe Ratio Rank
IBB Sortino Ratio Rank: 5050
Sortino Ratio Rank
IBB Omega Ratio Rank: 4646
Omega Ratio Rank
IBB Calmar Ratio Rank: 7171
Calmar Ratio Rank
IBB Martin Ratio Rank: 6262
Martin Ratio Rank
The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

SDGR vs. IBB - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Schrodinger, Inc. (SDGR) and iShares Nasdaq Biotechnology ETF (IBB). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

SDGRIBBDifference
Sharpe ratioReturn per unit of total volatility
-0.66
1.74

-2.41

Sortino ratioReturn per unit of downside risk
-0.76
2.50

-3.26

Omega ratioGain probability vs. loss probability

0.91

1.30

-0.39

Calmar ratioReturn relative to maximum drawdown

-0.60

3.60

-4.19

Martin ratioReturn relative to average drawdown

-0.91

11.43

-12.33

Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

SDGR vs. IBB - Sharpe Ratio Comparison

The current SDGR Sharpe Ratio is -0.66, which is lower than the IBB Sharpe Ratio of 1.74. The chart below compares the historical Sharpe Ratios of SDGR and IBB, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

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Sharpe Ratios by Period

SDGRIBBDifference

Sharpe Ratio (1Y)

Calculated over the trailing 1-year period

-0.66

1.74

-2.41

Sharpe Ratio (5Y)

Calculated over the trailing 5-year period

-0.43

0.10

-0.52

Sharpe Ratio (10Y)

Calculated over the trailing 10-year period

—

0.27

—

Sharpe Ratio (All Time)

Calculated using the full available price history

-0.14

0.26

-0.40

Drawdowns

SDGR vs. IBB - Drawdown Comparison

The maximum SDGR drawdown since its inception was -90.21%, which is greater than IBB's maximum drawdown of -62.85%. Use the drawdown chart below to compare losses from any high point for SDGR and IBB.

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Drawdown Indicators

SDGRIBBDifference

Max Drawdown

Largest peak-to-trough decline

-90.21%

-62.85%

-27.36%

Max Drawdown (1Y)

Largest decline over 1 year

-58.52%

-9.63%

-48.89%

Max Drawdown (3Y)

Largest decline over 3 years

-80.01%

-24.85%

-55.16%

Max Drawdown (5Y)

Largest decline over 5 years

-85.95%

-39.82%

-46.13%

Max Drawdown (10Y)

Largest decline over 10 years

—

-39.82%

—

Current Drawdown

Current decline from peak

-86.80%

-5.64%

-81.16%

Average Drawdown

Average peak-to-trough decline

-64.02%

-21.18%

-42.84%

Ulcer Index

Depth and duration of drawdowns from previous peaks

38.46%

3.03%

+35.43%

Volatility

SDGR vs. IBB - Volatility Comparison

Schrodinger, Inc. (SDGR) has a higher volatility of 15.91% compared to iShares Nasdaq Biotechnology ETF (IBB) at 6.86%. This indicates that SDGR's price experiences larger fluctuations and is considered to be riskier than IBB based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

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Volatility by Period

SDGRIBBDifference

Volatility (1M)

Calculated over the trailing 1-month period

15.91%

6.86%

+9.05%

Volatility (6M)

Calculated over the trailing 6-month period

37.14%

15.38%

+21.76%

Volatility (1Y)

Calculated over the trailing 1-year period

52.90%

19.89%

+33.01%

Volatility (5Y)

Calculated over the trailing 5-year period, annualized

63.18%

21.99%

+41.19%

Volatility (10Y)

Calculated over the trailing 10-year period, annualized

69.86%

23.22%

+46.64%

Dividends

SDGR vs. IBB - Dividend Comparison

SDGR has not paid dividends to shareholders, while IBB's dividend yield for the trailing twelve months is around 0.23%.

PositionTTM20252024202320222021202020192018201720162015
IBB
iShares Nasdaq Biotechnology ETF		0.23%0.23%0.29%0.26%0.31%0.21%0.21%0.33%0.20%0.30%0.19%0.03%
SDGR
Schrodinger, Inc.		0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%

Frequently Asked Questions

SDGR and IBB have a correlation of 0.44, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

SDGR has higher volatility (15.91%) compared to IBB (6.86%). In terms of maximum drawdown, SDGR dropped -90.21% vs IBB's -62.85%.

IBB currently has the higher Sharpe Ratio (1.74 vs -0.66), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.

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