SBIO vs. USOY
SBIO (ALPS Medical Breakthroughs ETF) and USOY (Defiance Oil Enhanced Options Income ETF) are both exchange-traded funds - SBIO is a Health & Biotech Equities fund tracking the S-Network Medical Breakthroughs Index, while USOY is a Derivative Income fund actively managed by Defiance. SBIO is passively managed, while USOY is actively managed. Over the past year, SBIO returned 68.86% vs 54.64% for USOY. At a correlation of -0.14, they often move in opposite directions. SBIO charges 0.50%/yr vs 1.22%/yr for USOY.
Performance
SBIO vs. USOY - Performance Comparison
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Returns By Period
In the year-to-date period, SBIO achieves a 1.95% return, which is significantly lower than USOY's 59.27% return.
SBIO
- 1D
- 2.35%
- 1M
- -5.55%
- YTD
- 1.95%
- 6M
- 4.13%
- 1Y
- 68.86%
- 3Y*
- 18.38%
- 5Y*
- 3.16%
- 10Y*
- 8.03%
USOY
- 1D
- -1.79%
- 1M
- -3.80%
- YTD
- 59.27%
- 6M
- 55.41%
- 1Y
- 54.64%
- 3Y*
- —
- 5Y*
- —
- 10Y*
- —
SBIO vs. USOY - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | |
|---|---|---|---|
SBIO ALPS Medical Breakthroughs ETF | 1.95% | 55.07% | 2.21% |
USOY Defiance Oil Enhanced Options Income ETF | 59.27% | -7.93% | 7.27% |
Correlation
The correlation between SBIO and USOY is -0.29, meaning they tend to move in opposite directions. This is especially valuable for risk management - when one declines, the other has historically tended to hold steady or rise.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | -0.29 |
Correlation (All Time) Calculated using the full available price history since May 13, 2024 | -0.14 |
The correlation between SBIO and USOY shifts across timeframes, from -0.29 (1 year) to -0.14 (all time), reflecting how their relationship changes across market environments.
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Return for Risk
SBIO vs. USOY — Risk / Return Rank
SBIO
USOY
SBIO vs. USOY - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for ALPS Medical Breakthroughs ETF (SBIO) and Defiance Oil Enhanced Options Income ETF (USOY). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| SBIO | USOY | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +0.55 | ||
| Sortino ratioReturn per unit of downside risk | +1.01 | ||
| Omega ratioGain probability vs. loss probability | 1.38 | 1.33 | +0.04 |
| Calmar ratioReturn relative to maximum drawdown | 5.47 | 3.84 | +1.63 |
| Martin ratioReturn relative to average drawdown | 16.23 | 7.37 | +8.86 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| SBIO | USOY | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 2.35 | 1.80 | +0.55 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | 0.09 | — | — |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | 0.24 | — | — |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.22 | 0.95 | -0.73 |
Drawdowns
SBIO vs. USOY - Drawdown Comparison
The maximum SBIO drawdown since its inception was -63.06%, which is greater than USOY's maximum drawdown of -17.46%. Use the drawdown chart below to compare losses from any high point for SBIO and USOY.
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Drawdown Indicators
| SBIO | USOY | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -63.06% | -17.46% | -45.60% |
Max Drawdown (1Y)Largest decline over 1 year | -12.66% | -14.29% | +1.63% |
Max Drawdown (3Y)Largest decline over 3 years | -42.44% | — | — |
Max Drawdown (5Y)Largest decline over 5 years | -53.10% | — | — |
Max Drawdown (10Y)Largest decline over 10 years | -63.06% | — | — |
Current DrawdownCurrent decline from peak | -14.84% | -6.81% | -8.03% |
Average DrawdownAverage peak-to-trough decline | -28.44% | -6.47% | -21.97% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 4.26% | 7.43% | -3.17% |
Volatility
SBIO vs. USOY - Volatility Comparison
The current volatility for ALPS Medical Breakthroughs ETF (SBIO) is 9.85%, while Defiance Oil Enhanced Options Income ETF (USOY) has a volatility of 11.67%. This indicates that SBIO experiences smaller price fluctuations and is considered to be less risky than USOY based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| SBIO | USOY | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 9.85% | 11.67% | -1.82% |
Volatility (6M)Calculated over the trailing 6-month period | 22.76% | 27.26% | -4.50% |
Volatility (1Y)Calculated over the trailing 1-year period | 29.40% | 30.50% | -1.10% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 33.57% | 26.14% | +7.43% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 33.18% | 26.14% | +7.04% |
SBIO vs. USOY - Expense Ratio Comparison
SBIO has a 0.50% expense ratio, which is lower than USOY's 1.22% expense ratio.
Dividends
SBIO vs. USOY - Dividend Comparison
SBIO has not paid dividends to shareholders, while USOY's dividend yield for the trailing twelve months is around 56.65%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
SBIO ALPS Medical Breakthroughs ETF | 0.00% | 0.00% | 3.55% | 0.22% | 0.00% | 0.00% | 0.00% | 0.04% | 2.79% | 1.77% |
USOY Defiance Oil Enhanced Options Income ETF | 56.65% | 104.32% | 48.60% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
Frequently Asked Questions
SBIO and USOY have a correlation of -0.29, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
USOY has higher volatility (11.67%) compared to SBIO (9.85%). In terms of maximum drawdown, SBIO dropped -63.06% vs USOY's -17.46%.
On 1-year performance, SBIO leads with 68.86% vs 54.64% for USOY. On fees, SBIO is cheaper at 0.50% per year. On volatility, SBIO has been the lower-risk option at 9.85%. The better choice depends on whether you care most about return, fees, risk, or income.
Over the 1-year period, SBIO has performed better with a 68.86% return vs 54.64%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.
SBIO is cheaper with a 0.50% expense ratio, compared with 1.22% for USOY.
USOY has the higher dividend yield at 56.65%, compared with 0.00% for SBIO.
SBIO is categorized as Health & Biotech Equities, while USOY is Derivative Income. They also come from different issuers: SS&C and Defiance. Their fees differ too: 0.50% for SBIO and 1.22% for USOY.
SBIO currently has the higher Sharpe Ratio (2.35 vs 1.80), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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