SYRE vs. FXAIX

Last updated Jun 24, 2026

SYRE (Spyre Therapeutics Inc.) is a stock, while FXAIX (Fidelity 500 Index Fund) is S&P 500 fund tracking the S&P 500 Index. Over the past 10 years, SYRE returned -3.17%/yr vs 15.80%/yr for FXAIX. At a 0.27 correlation, their price movements are largely independent.

Performance

SYRE vs. FXAIX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Spyre Therapeutics Inc. (SYRE) and Fidelity 500 Index Fund (FXAIX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, SYRE achieves a 196.25% return, which is significantly higher than FXAIX's 9.79% return. Over the past 10 years, SYRE has underperformed FXAIX with an annualized return of -3.17%, while FXAIX has yielded a comparatively higher 15.80% annualized return.

SYRE

• 1D: -3.26%
• 1M: 31.06%
• YTD: 196.25%
• 6M: 192.06%
• 1Y: 561.10%
• 3Y*: 113.30%
• 5Y*: -11.25%
• 10Y*: -3.17%

FXAIX

• 1D: -0.37%
• 1M: 0.10%
• YTD: 9.79%
• 6M: 8.79%
• 1Y: 25.51%
• 3Y*: 21.39%
• 5Y*: 13.60%
• 10Y*: 15.80%

*Multi-year figures are annualized to reflect compound growth (CAGR)

SYRE vs. FXAIX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
SYRE Spyre Therapeutics Inc.	196.25%	40.72%	8.18%	91.33%	-90.53%	-39.64%	3.01%	2.00%	38.45%	24.37%
FXAIX Fidelity 500 Index Fund	9.79%	17.84%	25.01%	26.29%	-18.14%	28.71%	18.42%	31.48%	-4.43%	21.82%

Correlation

The correlation between SYRE and FXAIX is 0.37, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.37
Correlation (3Y) Calculated over the trailing 3-year period	0.33
Correlation (5Y) Calculated over the trailing 5-year period	0.27
Correlation (10Y) Calculated over the trailing 10-year period	0.27
Correlation (All Time) Calculated using the full available price history since Apr 7, 2016	0.27

The correlation between SYRE and FXAIX shifts across timeframes, from 0.27 (10 years) to 0.37 (1 year), reflecting how their relationship changes across market environments.

Return for Risk

SYRE vs. FXAIX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

SYRE

SYRE Risk / Return Rank: 99
SYRE Sharpe Ratio Rank: 100
SYRE Sortino Ratio Rank: 99
SYRE Omega Ratio Rank: 98
SYRE Calmar Ratio Rank: 100
SYRE Martin Ratio Rank: 100

FXAIX

FXAIX Risk / Return Rank: 65
FXAIX Sharpe Ratio Rank: 64
FXAIX Sortino Ratio Rank: 57
FXAIX Omega Ratio Rank: 59
FXAIX Calmar Ratio Rank: 68
FXAIX Martin Ratio Rank: 78

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

SYRE vs. FXAIX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Spyre Therapeutics Inc. (SYRE) and Fidelity 500 Index Fund (FXAIX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	SYRE	FXAIX	Difference
Sharpe ratio: Return per unit of total volatility	8.24	2.15	+6.08
Sortino ratio: Return per unit of downside risk	6.24	2.91	+3.33
Omega ratio: Gain probability vs. loss probability	1.73	1.39	+0.35
Calmar ratio: Return relative to maximum drawdown	33.72	3.02	+30.70
Martin ratio: Return relative to average drawdown	94.51	13.62	+80.88

SYRE vs. FXAIX - Sharpe Ratio Comparison

The current SYRE Sharpe Ratio is 8.24, which is higher than the FXAIX Sharpe Ratio of 2.15. The chart below compares the historical Sharpe Ratios of SYRE and FXAIX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

SYRE vs. FXAIX - Drawdown Comparison

The maximum SYRE drawdown since its inception was -99.11%, which is greater than FXAIX's maximum drawdown of -33.79%. Use the drawdown chart below to compare losses from any high point for SYRE and FXAIX.

Drawdown Indicators

	SYRE	FXAIX	Difference
Max Drawdown Largest peak-to-trough decline	-99.11%	-33.79%	-65.32%
Max Drawdown (1Y) Largest decline over 1 year	-16.79%	-8.89%	-7.90%
Max Drawdown (3Y) Largest decline over 3 years	-73.99%	-18.76%	-55.23%
Max Drawdown (5Y) Largest decline over 5 years	-98.74%	-24.50%	-74.24%
Max Drawdown (10Y) Largest decline over 10 years	-99.04%	-33.79%	-65.25%
Current Drawdown Current decline from peak	-67.62%	-1.72%	-65.90%
Average Drawdown Average peak-to-trough decline	-62.69%	-3.79%	-58.90%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.98%	1.97%	+4.01%

Volatility

SYRE vs. FXAIX - Volatility Comparison

Spyre Therapeutics Inc. (SYRE) has a higher volatility of 20.99% compared to Fidelity 500 Index Fund (FXAIX) at 4.68%. This indicates that SYRE's price experiences larger fluctuations and is considered to be riskier than FXAIX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	SYRE	FXAIX	Difference
Volatility (1M) Calculated over the trailing 1-month period	20.99%	4.68%	+16.31%
Volatility (6M) Calculated over the trailing 6-month period	47.54%	9.84%	+37.70%
Volatility (1Y) Calculated over the trailing 1-year period	68.81%	12.50%	+56.31%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	179.28%	17.00%	+162.28%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	136.22%	18.12%	+118.10%

Dividends

SYRE vs. FXAIX - Dividend Comparison

SYRE has not paid dividends to shareholders, while FXAIX's dividend yield for the trailing twelve months is around 1.04%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
FXAIX Fidelity 500 Index Fund	1.04%	1.11%	1.25%	1.45%	1.69%	1.22%	1.60%	2.06%	2.72%	1.97%	2.52%	2.83%
SYRE Spyre Therapeutics Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both SYRE and FXAIX in my portfolio?

SYRE and FXAIX have a correlation of 0.37, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, SYRE or FXAIX?

SYRE has higher volatility (20.99%) compared to FXAIX (4.68%). In terms of maximum drawdown, SYRE dropped -99.11% vs FXAIX's -33.79%.

Which has better risk-adjusted returns?

SYRE currently has the higher Sharpe Ratio (8.23 vs 2.15), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.