SYRE vs. TQQQ
SYRE (Spyre Therapeutics Inc.) is a stock, while TQQQ (ProShares UltraPro QQQ) is Leveraged Equities fund tracking the NASDAQ-100 Index (300%). Over the past 10 years, SYRE returned -1.51%/yr vs 39.46%/yr for TQQQ. Their 0.25 correlation means their historical movements had little consistent relationship.
Performance
SYRE vs. TQQQ - Performance Comparison
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Returns By Period
In the year-to-date period, SYRE achieves a 200.15% return, which is significantly higher than TQQQ's 23.06% return. Over the past 10 years, SYRE has underperformed TQQQ with an annualized return of -1.51%, while TQQQ has yielded a comparatively higher 39.46% annualized return.
SYRE
- 1D
- -3.12%
- 1M
- 13.51%
- 6M
- 207.47%
- YTD
- 200.15%
- 1Y
- 504.74%
- 3Y*
- 92.49%
- 5Y*
- -8.49%
- 10Y*
- -1.51%
- ALL TIME*
- -8.65%
TQQQ
- 1D
- 2.09%
- 1M
- -11.90%
- 6M
- 20.14%
- YTD
- 23.06%
- 1Y
- 56.87%
- 3Y*
- 43.81%
- 5Y*
- 15.36%
- 10Y*
- 39.46%
- ALL TIME*
- 42.33%
Liquidity Comparison
| Position | Avg. Volume Value (2W) | Avg. Volume Value (1M) | Avg. Volume Value (3M) |
|---|---|---|---|
| $84.33M | $107.88M | $113.52M | |
| $4.37B | $4.57B | $5.33B |
SYRE vs. TQQQ - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
SYRE Spyre Therapeutics Inc. | 200.15% | 40.72% | 8.18% | 91.33% | -90.53% | -39.64% | 3.01% | 2.00% | 38.45% | 24.37% |
TQQQ ProShares UltraPro QQQ | 23.06% | 34.35% | 58.27% | 198.04% | -79.09% | 82.98% | 110.05% | 133.84% | -19.79% | 118.06% |
Correlation
The correlation between SYRE and TQQQ is 0.33, which is low. Their historical price movements had little consistent relationship.
| Correlation | |
|---|---|
Correlation (1Y) Focuses on recent behavior, but can change the most. | 0.33 |
Correlation (3Y) Balances recent behavior with more history. | 0.29 |
Correlation (5Y) Shows whether the relationship held over a longer period. | 0.25 |
Correlation (10Y) Provides a long-term view across more market conditions. | 0.25 |
Correlation (All Time) Calculated using the full available price history since Apr 7, 2016 | 0.25 |
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Return for Risk
SYRE vs. TQQQ — Risk / Return Rank
SYRE
TQQQ
SYRE vs. TQQQ - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Spyre Therapeutics Inc. (SYRE) and ProShares UltraPro QQQ (TQQQ). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| SYRE | TQQQ | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +6.13 | ||
| Sortino ratioReturn per unit of downside risk | +4.22 | ||
| Omega ratioGain probability vs. loss probability | 1.67 | 1.17 | +0.50 |
| Calmar ratioReturn relative to maximum drawdown | 32.61 | 1.29 | +31.32 |
| Martin ratioReturn relative to average drawdown | 84.47 | 3.60 | +80.87 |
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Drawdowns
SYRE vs. TQQQ - Drawdown Comparison
The maximum SYRE drawdown since its inception was -99.11%, which is greater than TQQQ's maximum drawdown of -81.66%. Use the drawdown chart below to compare losses from any high point for SYRE and TQQQ.
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Drawdown Indicators
| SYRE | TQQQ | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -99.11% | -81.66% | -17.45% |
Max Drawdown (1Y)Largest decline over 1 year | -14.83% | -36.97% | +22.14% |
Max Drawdown (3Y)Largest decline over 3 years | -73.99% | -58.04% | -15.95% |
Max Drawdown (5Y)Largest decline over 5 years | -98.74% | -81.66% | -17.08% |
Max Drawdown (10Y)Largest decline over 10 years | -99.04% | -81.66% | -17.38% |
Current DrawdownCurrent decline from peak | -67.20% | -25.74% | -41.46% |
Average DrawdownAverage peak-to-trough decline | -62.75% | -18.49% | -44.26% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 5.74% | 13.24% | -7.50% |
Volatility
SYRE vs. TQQQ - Volatility Comparison
The current volatility for Spyre Therapeutics Inc. (SYRE) is 17.95%, while ProShares UltraPro QQQ (TQQQ) has a volatility of 20.41%. This indicates that SYRE experiences smaller price fluctuations and is considered to be less risky than TQQQ based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| SYRE | TQQQ | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 17.95% | 20.41% | -2.46% |
Volatility (6M)Calculated over the trailing 6-month period | 49.88% | 47.79% | +2.09% |
Volatility (1Y)Calculated over the trailing 1-year period | 69.55% | 57.62% | +11.93% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 179.28% | 68.04% | +111.24% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 136.13% | 66.57% | +69.56% |
Dividends
SYRE vs. TQQQ - Dividend Comparison
SYRE has not paid dividends to shareholders, while TQQQ's dividend yield for the trailing twelve months is around 0.58%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
SYRE Spyre Therapeutics Inc. | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
TQQQ ProShares UltraPro QQQ | 0.58% | 0.65% | 1.27% | 1.26% | 0.57% | 0.00% | 0.00% | 0.06% | 0.11% | 0.00% | 0.00% | 0.01% |
Frequently Asked Questions
SYRE and TQQQ have a correlation of 0.33, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
TQQQ has higher volatility (20.41%) compared to SYRE (17.95%). In terms of maximum drawdown, SYRE dropped -99.11% vs TQQQ's -81.66%.
SYRE currently has the higher Sharpe Ratio (6.96 vs 0.83), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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