RNAZ vs. VOO
RNAZ (Transcode Therapeutics Inc) is a stock, while VOO (Vanguard S&P 500 ETF) is S&P 500 fund tracking the S&P 500 Index. Over the past 3 years, RNAZ returned -96.29%/yr vs 20.78%/yr for VOO. At a 0.19 correlation, their price movements are largely independent.
Performance
RNAZ vs. VOO - Performance Comparison
Loading charts...
Returns By Period
In the year-to-date period, RNAZ achieves a -28.92% return, which is significantly lower than VOO's 8.19% return.
RNAZ
- 1D
- -2.90%
- 1M
- -22.20%
- YTD
- -28.92%
- 6M
- -35.52%
- 1Y
- -35.27%
- 3Y*
- -96.29%
- 5Y*
- —
- 10Y*
- —
VOO
- 1D
- -1.42%
- 1M
- -1.34%
- YTD
- 8.19%
- 6M
- 7.24%
- 1Y
- 23.69%
- 3Y*
- 20.78%
- 5Y*
- 13.13%
- 10Y*
- 15.61%
RNAZ vs. VOO - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | |
|---|---|---|---|---|---|---|
RNAZ Transcode Therapeutics Inc | -28.92% | -92.76% | -98.45% | -98.78% | -73.50% | -36.50% |
VOO Vanguard S&P 500 ETF | 8.19% | 17.82% | 24.98% | 26.32% | -18.17% | 10.08% |
Correlation
The correlation between RNAZ and VOO is 0.19, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.19 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.16 |
Correlation (All Time) Calculated using the full available price history since Jul 8, 2021 | 0.19 |
Compare stocks, funds, or ETFs
Search for stocks, ETFs, and funds for a quick comparison or use the comparison tool for more options.
Return for Risk
RNAZ vs. VOO — Risk / Return Rank
RNAZ
VOO
RNAZ vs. VOO - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Transcode Therapeutics Inc (RNAZ) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| RNAZ | VOO | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -2.30 | ||
| Sortino ratioReturn per unit of downside risk | -2.66 | ||
| Omega ratioGain probability vs. loss probability | 0.99 | 1.35 | -0.35 |
| Calmar ratioReturn relative to maximum drawdown | -0.51 | 2.67 | -3.19 |
| Martin ratioReturn relative to average drawdown | -0.92 | 11.96 | -12.88 |
Loading charts...
Drawdowns
RNAZ vs. VOO - Drawdown Comparison
The maximum RNAZ drawdown since its inception was -100.00%, which is greater than VOO's maximum drawdown of -33.99%. Use the drawdown chart below to compare losses from any high point for RNAZ and VOO.
Loading charts...
Drawdown Indicators
| RNAZ | VOO | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -100.00% | -33.99% | -66.01% |
Max Drawdown (1Y)Largest decline over 1 year | -69.14% | -8.90% | -60.24% |
Max Drawdown (3Y)Largest decline over 3 years | -100.00% | -18.69% | -81.31% |
Max Drawdown (5Y)Largest decline over 5 years | — | -24.52% | — |
Max Drawdown (10Y)Largest decline over 10 years | — | -33.99% | — |
Current DrawdownCurrent decline from peak | -100.00% | -3.14% | -96.86% |
Average DrawdownAverage peak-to-trough decline | -89.62% | -3.68% | -85.94% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 38.51% | 1.99% | +36.52% |
Volatility
RNAZ vs. VOO - Volatility Comparison
Transcode Therapeutics Inc (RNAZ) has a higher volatility of 32.92% compared to Vanguard S&P 500 ETF (VOO) at 4.83%. This indicates that RNAZ's price experiences larger fluctuations and is considered to be riskier than VOO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
Loading charts...
Volatility by Period
| RNAZ | VOO | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 32.92% | 4.83% | +28.09% |
Volatility (6M)Calculated over the trailing 6-month period | 61.66% | 9.82% | +51.84% |
Volatility (1Y)Calculated over the trailing 1-year period | 91.88% | 12.46% | +79.42% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 207.62% | 16.91% | +190.71% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 207.62% | 18.02% | +189.60% |
Dividends
RNAZ vs. VOO - Dividend Comparison
RNAZ has not paid dividends to shareholders, while VOO's dividend yield for the trailing twelve months is around 1.05%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
RNAZ Transcode Therapeutics Inc | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
VOO Vanguard S&P 500 ETF | 1.05% | 1.13% | 1.24% | 1.46% | 1.69% | 1.25% | 1.54% | 1.88% | 2.06% | 1.78% | 2.02% | 2.10% |
Frequently Asked Questions
RNAZ and VOO have a correlation of 0.19, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
RNAZ has higher volatility (32.92%) compared to VOO (4.83%). In terms of maximum drawdown, RNAZ dropped -100.00% vs VOO's -33.99%.
VOO currently has the higher Sharpe Ratio (1.91 vs -0.39), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
Find the right allocation for RNAZ and VOO
Add both to a portfolio and optimize allocations for your target — whether that's maximizing returns, minimizing drawdowns, or balancing risk across holdings.
Open Portfolio Optimizer