PSIL vs. MEDI

Last updated Jun 4, 2026

PSIL (AdvisorShares Psychedelics ETF) and MEDI (Harbor Health Care ETF) are both Health & Biotech Equities funds. Both are actively managed. Over the past 3 years, PSIL returned 9.55%/yr vs 12.46%/yr for MEDI. At a 0.40 correlation, their price movements are largely independent. PSIL charges 1.00%/yr vs 0.80%/yr for MEDI.

Performance

PSIL vs. MEDI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in AdvisorShares Psychedelics ETF (PSIL) and Harbor Health Care ETF (MEDI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, PSIL achieves a 20.15% return, which is significantly higher than MEDI's -4.02% return.

PSIL

• 1D: -2.57%
• 1M: 1.88%
• YTD: 20.15%
• 6M: 23.74%
• 1Y: 65.52%
• 3Y*: 9.55%
• 5Y*: —
• 10Y*: —

MEDI

• 1D: 1.06%
• 1M: -0.93%
• YTD: -4.02%
• 6M: -4.83%
• 1Y: 18.27%
• 3Y*: 12.46%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

PSIL vs. MEDI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
PSIL AdvisorShares Psychedelics ETF	20.15%	74.55%	-19.50%	-25.12%	-20.17%
MEDI Harbor Health Care ETF	-4.02%	27.11%	0.58%	24.87%	2.60%

Correlation

The correlation between PSIL and MEDI is 0.47, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.47
Correlation (3Y) Calculated over the trailing 3-year period	0.40
Correlation (All Time) Calculated using the full available price history since Nov 18, 2022	0.40

PSIL vs. MEDI - Sectors Allocation Comparison

Sectors	PSIL	MEDI
Healthcare	100.0%	100.0%
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	-
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

PSIL vs. MEDI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PSIL

PSIL Risk / Return Rank: 48
PSIL Sharpe Ratio Rank: 46
PSIL Sortino Ratio Rank: 43
PSIL Omega Ratio Rank: 43
PSIL Calmar Ratio Rank: 66
PSIL Martin Ratio Rank: 43

MEDI

MEDI Risk / Return Rank: 26
MEDI Sharpe Ratio Rank: 26
MEDI Sortino Ratio Rank: 27
MEDI Omega Ratio Rank: 24
MEDI Calmar Ratio Rank: 25
MEDI Martin Ratio Rank: 26

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PSIL vs. MEDI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for AdvisorShares Psychedelics ETF (PSIL) and Harbor Health Care ETF (MEDI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PSIL	MEDI	Difference
Sharpe ratio: Return per unit of total volatility	1.58	0.93	+0.65
Sortino ratio: Return per unit of downside risk	2.14	1.46	+0.68
Omega ratio: Gain probability vs. loss probability	1.27	1.17	+0.11
Calmar ratio: Return relative to maximum drawdown	3.23	1.20	+2.03
Martin ratio: Return relative to average drawdown	6.82	3.59	+3.23
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PSIL vs. MEDI - Sharpe Ratio Comparison

The current PSIL Sharpe Ratio is 1.58, which is higher than the MEDI Sharpe Ratio of 0.93. The chart below compares the historical Sharpe Ratios of PSIL and MEDI, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	PSIL	MEDI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.58	0.93	+0.65
Sharpe Ratio (All Time) Calculated using the full available price history	-0.42	0.74	-1.15

Drawdowns

PSIL vs. MEDI - Drawdown Comparison

The maximum PSIL drawdown since its inception was -92.72%, which is greater than MEDI's maximum drawdown of -19.24%. Use the drawdown chart below to compare losses from any high point for PSIL and MEDI.

Drawdown Indicators

	PSIL	MEDI	Difference
Max Drawdown Largest peak-to-trough decline	-92.72%	-19.24%	-73.48%
Max Drawdown (1Y) Largest decline over 1 year	-20.38%	-15.34%	-5.04%
Max Drawdown (3Y) Largest decline over 3 years	-64.62%	-19.24%	-45.38%
Current Drawdown Current decline from peak	-76.63%	-8.01%	-68.62%
Average Drawdown Average peak-to-trough decline	-76.76%	-4.28%	-72.48%
Ulcer Index Depth and duration of drawdowns from previous peaks	9.63%	5.10%	+4.53%

Volatility

PSIL vs. MEDI - Volatility Comparison

AdvisorShares Psychedelics ETF (PSIL) has a higher volatility of 9.76% compared to Harbor Health Care ETF (MEDI) at 6.02%. This indicates that PSIL's price experiences larger fluctuations and is considered to be riskier than MEDI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PSIL	MEDI	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.76%	6.02%	+3.74%
Volatility (6M) Calculated over the trailing 6-month period	27.89%	15.42%	+12.47%
Volatility (1Y) Calculated over the trailing 1-year period	41.80%	19.82%	+21.98%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	63.15%	18.63%	+44.52%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	63.15%	18.63%	+44.52%

PSIL vs. MEDI - Expense Ratio Comparison

PSIL has a 1.00% expense ratio, which is higher than MEDI's 0.80% expense ratio.

Dividends

PSIL vs. MEDI - Dividend Comparison

PSIL's dividend yield for the trailing twelve months is around 8.32%, more than MEDI's 0.29% yield.

Position	TTM	2025	2024	2023	2022
MEDI Harbor Health Care ETF	0.29%	0.28%	0.54%	1.86%	0.00%
PSIL AdvisorShares Psychedelics ETF	8.32%	10.95%	1.49%	0.24%	2.91%

Frequently Asked Questions

Can I hold both PSIL and MEDI in my portfolio?

PSIL and MEDI have a correlation of 0.47, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, PSIL or MEDI?

PSIL has higher volatility (9.76%) compared to MEDI (6.02%). In terms of maximum drawdown, PSIL dropped -92.72% vs MEDI's -19.24%.

Which ETF is better, PSIL or MEDI?

On 3-year performance, MEDI leads with 12.46% vs 9.55% for PSIL. On fees, MEDI is cheaper at 0.80% per year. On volatility, MEDI has been the lower-risk option at 6.02%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, PSIL or MEDI?

Over the 3-year period, MEDI has performed better with a 12.46% return vs 9.55%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, PSIL or MEDI?

MEDI is cheaper with a 0.80% expense ratio, compared with 1.00% for PSIL.

Which ETF pays a higher dividend yield, PSIL or MEDI?

PSIL has the higher dividend yield at 8.32%, compared with 0.29% for MEDI.

What is the main difference between PSIL and MEDI?

They also come from different issuers: AdvisorShares and Harbor. Their fees differ too: 1.00% for PSIL and 0.80% for MEDI.

Which has better risk-adjusted returns?

PSIL currently has the higher Sharpe Ratio (1.58 vs 0.93), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.