PHIO vs. IAK

Last updated Jun 3, 2026

PHIO (Phio Pharmaceuticals Corp.) is a stock, while IAK (iShares U.S. Insurance ETF) is Financials Equities fund tracking the Dow Jones U.S. Select Insurance Index. Over the past 10 years, PHIO returned -68.82%/yr vs 11.76%/yr for IAK. At a 0.13 correlation, their price movements are largely independent.

Performance

PHIO vs. IAK - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Phio Pharmaceuticals Corp. (PHIO) and iShares U.S. Insurance ETF (IAK). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, PHIO achieves a 6.67% return, which is significantly higher than IAK's -3.71% return. Over the past 10 years, PHIO has underperformed IAK with an annualized return of -68.82%, while IAK has yielded a comparatively higher 11.76% annualized return.

PHIO

• 1D: -0.88%
• 1M: -1.75%
• YTD: 6.67%
• 6M: -8.94%
• 1Y: -45.37%
• 3Y*: -66.60%
• 5Y*: -65.65%
• 10Y*: -68.82%

IAK

• 1D: 0.76%
• 1M: -2.20%
• YTD: -3.71%
• 6M: -1.09%
• 1Y: -3.43%
• 3Y*: 17.08%
• 5Y*: 11.73%
• 10Y*: 11.76%

*Multi-year figures are annualized to reflect compound growth (CAGR)

PHIO vs. IAK - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
PHIO Phio Pharmaceuticals Corp.	6.67%	-41.67%	-73.68%	-82.97%	-62.80%	-62.83%	-71.40%	-48.17%	-94.07%	-22.21%
IAK iShares U.S. Insurance ETF	-3.71%	9.50%	28.25%	11.28%	11.33%	26.84%	-2.86%	25.94%	-11.48%	14.18%

Correlation

The correlation between PHIO and IAK is 0.08, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.08
Correlation (3Y) Calculated over the trailing 3-year period	0.04
Correlation (5Y) Calculated over the trailing 5-year period	0.09
Correlation (10Y) Calculated over the trailing 10-year period	0.12
Correlation (All Time) Calculated using the full available price history since May 11, 2012	0.13

Return for Risk

PHIO vs. IAK — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PHIO

PHIO Risk / Return Rank: 20
PHIO Sharpe Ratio Rank: 18
PHIO Sortino Ratio Rank: 20
PHIO Omega Ratio Rank: 21
PHIO Calmar Ratio Rank: 18
PHIO Martin Ratio Rank: 22

IAK

IAK Risk / Return Rank: 6
IAK Sharpe Ratio Rank: 7
IAK Sortino Ratio Rank: 6
IAK Omega Ratio Rank: 6
IAK Calmar Ratio Rank: 5
IAK Martin Ratio Rank: 5

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PHIO vs. IAK - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Phio Pharmaceuticals Corp. (PHIO) and iShares U.S. Insurance ETF (IAK). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PHIO	IAK	Difference
Sharpe ratio Return per unit of total volatility	-0.53	-0.23	-0.29
Sortino ratio Return per unit of downside risk	-0.46	-0.22	-0.24
Omega ratio Gain probability vs. loss probability	0.95	0.97	-0.03
Calmar ratio Return relative to maximum drawdown	-0.62	-0.33	-0.29
Martin ratio Return relative to average drawdown	-0.91	-0.67	-0.24
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PHIO vs. IAK - Sharpe Ratio Comparison

The current PHIO Sharpe Ratio is -0.53, which is lower than the IAK Sharpe Ratio of -0.23. The chart below compares the historical Sharpe Ratios of PHIO and IAK, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	PHIO	IAK	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.53	-0.23	-0.29
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.36	0.65	-1.01
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.46	0.56	-1.02
Sharpe Ratio (All Time) Calculated using the full available price history	-0.25	0.26	-0.51

Drawdowns

PHIO vs. IAK - Drawdown Comparison

The maximum PHIO drawdown since its inception was -100.00%, which is greater than IAK's maximum drawdown of -77.38%. Use the drawdown chart below to compare losses from any high point for PHIO and IAK.

Drawdown Indicators

	PHIO	IAK	Difference
Max Drawdown Largest peak-to-trough decline	-100.00%	-77.38%	-22.62%
Max Drawdown (1Y) Largest decline over 1 year	-71.05%	-7.98%	-63.07%
Max Drawdown (3Y) Largest decline over 3 years	-97.15%	-11.58%	-85.57%
Max Drawdown (5Y) Largest decline over 5 years	-99.67%	-14.76%	-84.91%
Max Drawdown (10Y) Largest decline over 10 years	-100.00%	-44.95%	-55.05%
Current Drawdown Current decline from peak	-100.00%	-4.98%	-95.02%
Average Drawdown Average peak-to-trough decline	-91.33%	-16.14%	-75.19%
Ulcer Index Depth and duration of drawdowns from previous peaks	48.14%	4.01%	+44.13%

Volatility

PHIO vs. IAK - Volatility Comparison

Phio Pharmaceuticals Corp. (PHIO) has a higher volatility of 11.39% compared to iShares U.S. Insurance ETF (IAK) at 3.80%. This indicates that PHIO's price experiences larger fluctuations and is considered to be riskier than IAK based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PHIO	IAK	Difference
Volatility (1M) Calculated over the trailing 1-month period	11.39%	3.80%	+7.59%
Volatility (6M) Calculated over the trailing 6-month period	64.55%	9.98%	+54.57%
Volatility (1Y) Calculated over the trailing 1-year period	86.33%	14.76%	+71.57%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	183.79%	18.07%	+165.72%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	150.20%	20.89%	+129.31%

Dividends

PHIO vs. IAK - Dividend Comparison

PHIO has not paid dividends to shareholders, while IAK's dividend yield for the trailing twelve months is around 2.73%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
IAK iShares U.S. Insurance ETF	2.73%	1.69%	1.49%	1.44%	1.69%	2.26%	2.07%	1.84%	2.33%	1.62%	1.68%	1.62%
PHIO Phio Pharmaceuticals Corp.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both PHIO and IAK in my portfolio?

PHIO and IAK have a correlation of 0.08, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, PHIO or IAK?

PHIO has higher volatility (11.39%) compared to IAK (3.80%). In terms of maximum drawdown, PHIO dropped -100.00% vs IAK's -77.38%.

Which has better risk-adjusted returns?

IAK currently has the higher Sharpe Ratio (-0.23 vs -0.53), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.