Phio Pharmaceuticals Corp. (PHIO)

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Phio Pharmaceuticals Corp. (PHIO) is up 6.7% since the beginning of the year. At $1 per share, PHIO is trading 73.3% below its 52-week high of $4. Investors who bought $1,000 worth of PHIO shares 5 years ago would now be looking at an investment worth $5.

Phio Pharmaceuticals Corp. (PHIO) has returned 6.67% so far this year and -45.37% over the past 12 months. Over the last ten years, PHIO has returned -68.82% per year, falling short of the S&P 500 Index benchmark, which averaged 13.75% annually.

Based on dividend-adjusted daily data since May 10, 2012, PHIO's average daily return is +0.07%, while the average monthly return is -5.33%.

Historically, 34% of months were positive and 66% were negative. The best month was Feb 2013 with a return of +100.0%, while the worst month was Feb 2020 at -68.2%. The longest winning streak lasted 4 consecutive months, and the longest losing streak was 8 months.

On a daily basis, PHIO closed higher 40% of trading days. The best single day was Jul 18, 2012 with a return of +806.2%, while the worst single day was Jul 9, 2012 at -88.9%.

Phio Pharmaceuticals Corp. has an annualized alpha of 5.35%, beta of 0.98, and R2 of 0.00 versus S&P 500 Index. Calculated based on daily prices since May 11, 2012.

• This stock participated in 244.02% of S&P 500 Index downside but only -102.31% of its upside - more exposed to losses than it benefited from rallies.
• R2 of 0.00 means this stock moves largely independently of S&P 500 Index - capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.

PHIO ranks 19 for risk / return — in the bottom 19% of stocks on our site. This means you're taking on significantly more risk than the returns justify. Consider whether the potential upside is worth the volatility, or explore alternatives with better risk / return profiles.

The table below present risk-adjusted performance metrics for Phio Pharmaceuticals Corp. (PHIO) and compare them to S&P 500 Index.

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.

The table below displays the maximum drawdowns of the Phio Pharmaceuticals Corp.. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the Phio Pharmaceuticals Corp. was 100.00%, occurring on Feb 5, 2026. The portfolio has not yet recovered.

The current Phio Pharmaceuticals Corp. drawdown is 100.00%.

The chart below shows the rolling one-month volatility.

The chart below illustrates the trends in the financial health of Phio Pharmaceuticals Corp. over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.

The Valuation section provides an overview of how Phio Pharmaceuticals Corp. is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.