ORKA vs. QSI

Last updated Jun 4, 2026

ORKA (Oruka Therapeutics, Inc) and QSI (Quantum-Si incorporated) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 3 years, ORKA returned 61.35%/yr vs -11.03%/yr for QSI. At a 0.25 correlation, their price movements are largely independent.

Performance

ORKA vs. QSI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Oruka Therapeutics, Inc (ORKA) and Quantum-Si incorporated (QSI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ORKA achieves a 88.72% return, which is significantly higher than QSI's 8.18% return.

ORKA

• 1D: 3.57%
• 1M: -13.93%
• YTD: 88.72%
• 6M: 93.24%
• 1Y: 379.06%
• 3Y*: 61.35%
• 5Y*: 19.94%
• 10Y*: -17.30%

QSI

• 1D: -4.03%
• 1M: 22.49%
• YTD: 8.18%
• 6M: -12.50%
• 1Y: -32.39%
• 3Y*: -11.03%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

ORKA vs. QSI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
ORKA Oruka Therapeutics, Inc	88.72%	56.32%	76.73%	-28.27%	10.23%	-41.73%
QSI Quantum-Si incorporated	8.18%	-59.26%	34.33%	9.84%	-76.75%	-26.31%

Correlation

The correlation between ORKA and QSI is 0.31, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.31
Correlation (3Y) Calculated over the trailing 3-year period	0.25
Correlation (All Time) Calculated using the full available price history since Jun 11, 2021	0.25

Fundamentals

Market Cap ORKA : $3.16B QSI : $257.60M
EPS ORKA : -$2.37 QSI : -$0.51
PB Ratio ORKA : 6.52 QSI : 1.28
Total Revenue (TTM) ORKA : $0.00 QSI : $1.85M
Gross Profit (TTM) ORKA : -$71.00K QSI : -$3.71M
EBITDA (TTM) ORKA : -$125.61M QSI : -$104.05M

Return for Risk

ORKA vs. QSI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ORKA

ORKA Risk / Return Rank: 97
ORKA Sharpe Ratio Rank: 98
ORKA Sortino Ratio Rank: 97
ORKA Omega Ratio Rank: 94
ORKA Calmar Ratio Rank: 98
ORKA Martin Ratio Rank: 99

QSI

QSI Risk / Return Rank: 28
QSI Sharpe Ratio Rank: 26
QSI Sortino Ratio Rank: 31
QSI Omega Ratio Rank: 30
QSI Calmar Ratio Rank: 25
QSI Martin Ratio Rank: 28

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ORKA vs. QSI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Oruka Therapeutics, Inc (ORKA) and Quantum-Si incorporated (QSI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ORKA	QSI	Difference
Sharpe ratio Return per unit of total volatility	5.10	-0.35	+5.45
Sortino ratio Return per unit of downside risk	4.64	0.03	+4.61
Omega ratio Gain probability vs. loss probability	1.55	1.00	+0.54
Calmar ratio Return relative to maximum drawdown	13.65	-0.45	+14.10
Martin ratio Return relative to average drawdown	45.14	-0.67	+45.81
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ORKA vs. QSI - Sharpe Ratio Comparison

The current ORKA Sharpe Ratio is 5.10, which is higher than the QSI Sharpe Ratio of -0.35. The chart below compares the historical Sharpe Ratios of ORKA and QSI, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	ORKA	QSI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	5.10	-0.35	+5.45
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.28	—	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.11	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.23	-0.29	+0.06

Drawdowns

ORKA vs. QSI - Drawdown Comparison

The maximum ORKA drawdown since its inception was -100.00%, roughly equal to the maximum QSI drawdown of -95.33%. Use the drawdown chart below to compare losses from any high point for ORKA and QSI.

Drawdown Indicators

	ORKA	QSI	Difference
Max Drawdown Largest peak-to-trough decline	-100.00%	-95.33%	-4.67%
Max Drawdown (1Y) Largest decline over 1 year	-27.99%	-72.95%	+44.96%
Max Drawdown (3Y) Largest decline over 3 years	-77.76%	-83.73%	+5.97%
Max Drawdown (5Y) Largest decline over 5 years	-77.76%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-98.38%	—	—
Current Drawdown Current decline from peak	-100.00%	-91.22%	-8.78%
Average Drawdown Average peak-to-trough decline	-93.87%	-79.26%	-14.61%
Ulcer Index Depth and duration of drawdowns from previous peaks	8.45%	48.36%	-39.91%

Volatility

ORKA vs. QSI - Volatility Comparison

The current volatility for Oruka Therapeutics, Inc (ORKA) is 16.19%, while Quantum-Si incorporated (QSI) has a volatility of 22.20%. This indicates that ORKA experiences smaller price fluctuations and is considered to be less risky than QSI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ORKA	QSI	Difference
Volatility (1M) Calculated over the trailing 1-month period	16.19%	22.20%	-6.01%
Volatility (6M) Calculated over the trailing 6-month period	50.17%	58.29%	-8.12%
Volatility (1Y) Calculated over the trailing 1-year period	74.88%	92.68%	-17.80%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	72.23%	125.41%	-53.18%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	152.46%	125.41%	+27.05%

Dividends

ORKA vs. QSI - Dividend Comparison

Neither ORKA nor QSI has paid dividends to shareholders.

Position	TTM	2025	2024
ORKA Oruka Therapeutics, Inc	0.00%	0.00%	99.82%
QSI Quantum-Si incorporated	0.00%	0.00%	0.00%

Financials

Frequently Asked Questions

Can I hold both ORKA and QSI in my portfolio?

ORKA and QSI have a correlation of 0.31, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ORKA or QSI?

QSI has higher volatility (22.20%) compared to ORKA (16.19%). In terms of maximum drawdown, ORKA dropped -100.00% vs QSI's -95.33%.

Which has better risk-adjusted returns?

ORKA currently has the higher Sharpe Ratio (5.10 vs -0.35), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.