QSI vs. DNA

Last updated Apr 2, 2026

Compare and contrast key facts about Quantum-Si incorporated (QSI) and Ginkgo Bioworks Holdings, Inc. (DNA).

Performance

QSI vs. DNA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Quantum-Si incorporated (QSI) and Ginkgo Bioworks Holdings, Inc. (DNA). The values are adjusted to include any dividend payments, if applicable.

QSI vs. DNA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
QSI Quantum-Si incorporated	-32.04%	-59.26%	34.33%	9.84%	-76.75%	-26.31%
DNA Ginkgo Bioworks Holdings, Inc.	-18.29%	-15.38%	-85.47%	0.00%	-79.66%	-16.90%

Fundamentals

Market Cap QSI : $147.85M DNA : $376.56M
EPS QSI : -$0.51 DNA : -$5.65
PS Ratio QSI : 60.40 DNA : 2.21
PB Ratio QSI : 0.67 DNA : 0.74
Total Revenue (TTM) QSI : $2.44M DNA : $170.16M
Gross Profit (TTM) QSI : $1.15M DNA : $138.63M
EBITDA (TTM) QSI : -$99.74M DNA : -$215.86M

Returns By Period

In the year-to-date period, QSI achieves a -32.04% return, which is significantly lower than DNA's -18.29% return.

QSI

• 1D: -3.41%
• 1M: -19.91%
• YTD: -32.04%
• 6M: -48.79%
• 1Y: -37.70%
• 3Y*: -24.83%
• 5Y*: —
• 10Y*: —

DNA

• 1D: 10.77%
• 1M: -3.69%
• YTD: -18.29%
• 6M: -53.72%
• 1Y: 19.96%
• 3Y*: -49.65%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

QSI vs. DNA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

QSI

QSI Risk / Return Rank: 25
QSI Sharpe Ratio Rank: 23
QSI Sortino Ratio Rank: 27
QSI Omega Ratio Rank: 27
QSI Calmar Ratio Rank: 23
QSI Martin Ratio Rank: 24

DNA

DNA Risk / Return Rank: 50
DNA Sharpe Ratio Rank: 48
DNA Sortino Ratio Rank: 55
DNA Omega Ratio Rank: 53
DNA Calmar Ratio Rank: 48
DNA Martin Ratio Rank: 47

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

QSI vs. DNA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Quantum-Si incorporated (QSI) and Ginkgo Bioworks Holdings, Inc. (DNA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	QSI	DNA	Difference
Sharpe ratio Return per unit of total volatility	-0.40	0.20	-0.60
Sortino ratio Return per unit of downside risk	-0.07	1.03	-1.10
Omega ratio Gain probability vs. loss probability	0.99	1.13	-0.13
Calmar ratio Return relative to maximum drawdown	-0.52	0.29	-0.81
Martin ratio Return relative to average drawdown	-0.93	0.59	-1.51
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

QSI vs. DNA - Sharpe Ratio Comparison

The current QSI Sharpe Ratio is -0.40, which is lower than the DNA Sharpe Ratio of 0.20. The chart below compares the historical Sharpe Ratios of QSI and DNA, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	QSI	DNA	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.40	0.20	-0.60
Sharpe Ratio (All Time) Calculated using the full available price history	-0.34	-0.58	+0.24

Correlation

The correlation between QSI and DNA is 0.50, which is considered to be moderate. This suggests that the two assets have some degree of positive relationship in their price movements. Moderate correlation can be acceptable for portfolio diversification, offering a balance between risk and potential returns.

Dividends

QSI vs. DNA - Dividend Comparison

Neither QSI nor DNA has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

QSI vs. DNA - Drawdown Comparison

The maximum QSI drawdown since its inception was -95.33%, roughly equal to the maximum DNA drawdown of -99.10%. Use the drawdown chart below to compare losses from any high point for QSI and DNA.

Drawdown Indicators

	QSI	DNA	Difference
Max Drawdown Largest peak-to-trough decline	-95.33%	-99.10%	+3.77%
Max Drawdown (1Y) Largest decline over 1 year	-71.95%	-66.05%	-5.90%
Current Drawdown Current decline from peak	-94.49%	-98.86%	+4.37%
Average Drawdown Average peak-to-trough decline	-78.77%	-79.00%	+0.23%
Ulcer Index Depth and duration of drawdowns from previous peaks	40.69%	32.62%	+8.07%

Volatility

QSI vs. DNA - Volatility Comparison

The current volatility for Quantum-Si incorporated (QSI) is 22.91%, while Ginkgo Bioworks Holdings, Inc. (DNA) has a volatility of 29.62%. This indicates that QSI experiences smaller price fluctuations and is considered to be less risky than DNA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	QSI	DNA	Difference
Volatility (1M) Calculated over the trailing 1-month period	22.91%	29.62%	-6.71%
Volatility (6M) Calculated over the trailing 6-month period	63.03%	73.07%	-10.04%
Volatility (1Y) Calculated over the trailing 1-year period	95.18%	100.68%	-5.50%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	126.20%	96.73%	+29.47%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	126.20%	96.73%	+29.47%

Financials