QSI vs. DNA

Last updated Jun 4, 2026

QSI (Quantum-Si incorporated) and DNA (Ginkgo Bioworks Holdings, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 3 years, QSI returned -11.03%/yr vs -48.74%/yr for DNA. At a 0.50 correlation, their price movements are largely independent.

Performance

QSI vs. DNA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Quantum-Si incorporated (QSI) and Ginkgo Bioworks Holdings, Inc. (DNA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, QSI achieves a 8.18% return, which is significantly higher than DNA's 5.05% return.

QSI

• 1D: -4.03%
• 1M: 22.49%
• YTD: 8.18%
• 6M: -12.50%
• 1Y: -32.39%
• 3Y*: -11.03%
• 5Y*: —
• 10Y*: —

DNA

• 1D: -6.43%
• 1M: -11.91%
• YTD: 5.05%
• 6M: -3.11%
• 1Y: 16.71%
• 3Y*: -48.74%
• 5Y*: -53.34%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

QSI vs. DNA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
QSI Quantum-Si incorporated	8.18%	-59.26%	34.33%	9.84%	-76.75%	-26.31%
DNA Ginkgo Bioworks Holdings, Inc.	5.05%	-15.38%	-85.47%	0.00%	-79.66%	-16.90%

Correlation

The correlation between QSI and DNA is 0.54, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.54
Correlation (3Y) Calculated over the trailing 3-year period	0.51
Correlation (All Time) Calculated using the full available price history since Jun 11, 2021	0.50

The correlation between QSI and DNA has been stable across timeframes, ranging from 0.50 to 0.54 - a consistent structural relationship.

Fundamentals

Market Cap QSI : $257.60M DNA : $519.99M
EPS QSI : -$0.51 DNA : -$5.40
PS Ratio QSI : 129.62 DNA : 4.04
PB Ratio QSI : 1.28 DNA : 1.17
Total Revenue (TTM) QSI : $1.85M DNA : $121.84M
Gross Profit (TTM) QSI : -$3.71M DNA : $99.27M
EBITDA (TTM) QSI : -$104.05M DNA : -$218.90M

Return for Risk

QSI vs. DNA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

QSI

QSI Risk / Return Rank: 28
QSI Sharpe Ratio Rank: 26
QSI Sortino Ratio Rank: 31
QSI Omega Ratio Rank: 30
QSI Calmar Ratio Rank: 25
QSI Martin Ratio Rank: 28

DNA

DNA Risk / Return Rank: 49
DNA Sharpe Ratio Rank: 46
DNA Sortino Ratio Rank: 53
DNA Omega Ratio Rank: 52
DNA Calmar Ratio Rank: 46
DNA Martin Ratio Rank: 45

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

QSI vs. DNA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Quantum-Si incorporated (QSI) and Ginkgo Bioworks Holdings, Inc. (DNA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	QSI	DNA	Difference
Sharpe ratio Return per unit of total volatility	-0.35	0.17	-0.52
Sortino ratio Return per unit of downside risk	0.03	0.96	-0.93
Omega ratio Gain probability vs. loss probability	1.00	1.12	-0.12
Calmar ratio Return relative to maximum drawdown	-0.45	0.25	-0.70
Martin ratio Return relative to average drawdown	-0.67	0.44	-1.11
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

QSI vs. DNA - Sharpe Ratio Comparison

The current QSI Sharpe Ratio is -0.35, which is lower than the DNA Sharpe Ratio of 0.17. The chart below compares the historical Sharpe Ratios of QSI and DNA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	QSI	DNA	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.35	0.17	-0.52
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	-0.55	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.29	-0.55	+0.26

Drawdowns

QSI vs. DNA - Drawdown Comparison

The maximum QSI drawdown since its inception was -95.33%, roughly equal to the maximum DNA drawdown of -99.10%. Use the drawdown chart below to compare losses from any high point for QSI and DNA.

Drawdown Indicators

	QSI	DNA	Difference
Max Drawdown Largest peak-to-trough decline	-95.33%	-99.10%	+3.77%
Max Drawdown (1Y) Largest decline over 1 year	-72.95%	-66.05%	-6.90%
Max Drawdown (3Y) Largest decline over 3 years	-83.73%	-94.72%	+10.99%
Max Drawdown (5Y) Largest decline over 5 years	—	-99.10%	—
Current Drawdown Current decline from peak	-91.22%	-98.54%	+7.32%
Average Drawdown Average peak-to-trough decline	-79.26%	-79.65%	+0.39%
Ulcer Index Depth and duration of drawdowns from previous peaks	48.36%	38.26%	+10.10%

Volatility

QSI vs. DNA - Volatility Comparison

The current volatility for Quantum-Si incorporated (QSI) is 22.20%, while Ginkgo Bioworks Holdings, Inc. (DNA) has a volatility of 24.18%. This indicates that QSI experiences smaller price fluctuations and is considered to be less risky than DNA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	QSI	DNA	Difference
Volatility (1M) Calculated over the trailing 1-month period	22.20%	24.18%	-1.98%
Volatility (6M) Calculated over the trailing 6-month period	58.29%	70.30%	-12.01%
Volatility (1Y) Calculated over the trailing 1-year period	92.68%	98.87%	-6.19%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	125.41%	97.70%	+27.71%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	125.41%	96.49%	+28.92%

Dividends

QSI vs. DNA - Dividend Comparison

Neither QSI nor DNA has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both QSI and DNA in my portfolio?

QSI and DNA have a correlation of 0.54, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, QSI or DNA?

DNA has higher volatility (24.18%) compared to QSI (22.20%). In terms of maximum drawdown, QSI dropped -95.33% vs DNA's -99.10%.

Which has better risk-adjusted returns?

DNA currently has the higher Sharpe Ratio (0.17 vs -0.35), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.